Hydroxyacyl-thioester dehydratase type 2, mitochondrial (P38790)

Identification
NameHydroxyacyl-thioester dehydratase type 2, mitochondrial
Synonyms
  • 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Gene NameHTD2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in 3-hydroxyacyl-[acyl-carrier-protein] dehydr
Specific FunctionMitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis. Required for respiratory growth and for normal mitochondrial morphology
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>843 bp ATGAAATCCAAAACGTGGATTTTCAGGGATGTCTTATCTAGTCACCGAACCAAAGCGTTT GATAGTTTACTTTGTAGGAGACTCCCTGTATCAAAGGCAACGAAGCATCTTCAACTGGGA GAACATTTCCTGTTCTTCCCACCATCATTCGAAAAATTGGATAGAGATGGTTATTTTAAC TATCAAAATCCTGCAAGTTTGCTAGGAAACCCTGATTTACGCTACCGTAGAAGGATTTGG GGACAAGGAGAGCTTGTTCAGTATTTACCAGTCACCTTAGACCAGGAGTATACATGCCAC GAATCAATCAAATACGTAAAAAAAATACGAGATGAACATGTTGTCTGTATTGAAAGAACC CTTTTACAAGAAAGGCCCGAAAATGTGTCGAGTCCAATGGACATTTGCTTATTCGAGAGA AGGGTATTAATGTACACCAATTCACCCGCAAACAAGACTGCAGTCAAGATGCCCGTAGGA GAGGAGAACTATAAGATCTTAAAAAATTTTACTGTTACTGATATGGATATTGTAGCTTAT GGTCAGATGTCTTTGAATCCGCACCGAATTCATTGGGACAAAGAGTACAGTCGCTATGTT GAAGGCTACGACGATATTATCATGCAAGGACCCTTCTCGGTCCAATTACTACAGAAATGC ATCCAACCTTTTCTCGAACAACCAATCAGACAGTTGCGATACCGCAATTTGAATTATATA TATCCAAACACTACTTTGAGCATATGTCAGTCTTTAAGCTCTTCGAGCGGAATGTACACA TTTCAAATTAGGGACCTCCAGAAAGCCAACTTAGTCTACATGAAAGCTGATGTTTTCTGT TGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues280
Protein Molecular Weight33054.80078
Protein Theoretical pI8.92
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Hydroxyacyl-thioester dehydratase type 2, mitochondrial MKSKTWIFRDVLSSHRTKAFDSLLCRRLPVSKATKHLQLGEHFLFFPPSFEKLDRDGYFN YQNPASLLGNPDLRYRRRIWGQGELVQYLPVTLDQEYTCHESIKYVKKIRDEHVVCIERT LLQERPENVSSPMDICLFERRVLMYTNSPANKTAVKMPVGEENYKILKNFTVTDMDIVAY GQMSLNPHRIHWDKEYSRYVEGYDDIIMQGPFSVQLLQKCIQPFLEQPIRQLRYRNLNYI YPNTTLSICQSLSSSSGMYTFQIRDLQKANLVYMKADVFC
References
External Links
ResourceLink
Saccharomyces Genome Database HTD2
Uniprot IDP38790
Uniprot NameHTD2_YEAST
GenBank Gene IDU00061
Genebank Protein ID487947
General Reference
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kastaniotis, A. J., Autio, K. J., Sormunen, R. T., Hiltunen, J. K. (2004). "Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology." Mol Microbiol 53:1407-1421.15387819
  • Reinders, J., Zahedi, R. P., Pfanner, N., Meisinger, C., Sickmann, A. (2006). "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res 5:1543-1554.16823961