Oxysterol-binding protein homolog 3 (P38713)

Identification
NameOxysterol-binding protein homolog 3
SynonymsNot Available
Gene NameOSH3
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionNot Available
Cellular LocationCytoplasm.
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Process
metabolic process
primary metabolic process
lipid metabolic process
steroid metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2991 bp ATGGAAACAATTGATATACAAAATCGATCATTTGTTGTTCGTTGGGTAAAATGTGGCCGT GGCGATGTAATCAATTATCAGATCAAGCCATTGAAGAAATCTATTGAAGTCGGCATATAC AAAAAGTTGAAATCCAGTGTAGATGACCATGCTTCCGCAGTTCACATTGCACCTGACACT AAAACATTGCTAGACTATACTACGAAATCTCTATTACATAAGGGAAGTTCGAGTAATATT GAGGAGCATCACAGGCGTTCCTCACAGCACTCTCATAGTTCGAGCAATGGATCGGATAAT AAGAGGAAAGAGAGATCATATTCTTCACTGTCCATTAGCGGCATACAGCAGCAATCCCAG GAAATACCCCTACGTGAAAAACTCTCTGCGTCAGGATTCACTTTGGTCAAGAGGGTCGGC AACGTTTCCGGTAACACTATGGTCCAAGGTGATCTTGAAGTGAAAGATACAGACTACTAT TATGCATTTATACTGGACAACTCGTCTTCCAAGAATGCAAAAAAGAAAATTCTTTTTAAC GCAAGTGTGATAAACGGCGATAATCAATCGATGATAAGCACAAGATCCACCCCTCCCGCA AGGCCTACAGCTTTAAGCAGAACATCTACTCAACAGGATATGTTATTTAGAGTAGGACAA GGTCGTTACTTGCAAGGCTACCTGCTGAAAAAAAGGAGAAAGAGACTACAAGGTTTTAAG AAAAGGTTTTTCACCTTGGACTTTCGATATGGAACCCTATCGTACTATTTAAACGACCAT AATCAAACTTGTAGGGGTGAAATTGTCATAAGCTTGTCATCTGTTAGTGCCAATAAGAAG GACAAAATAATCATAATTGATTCTGGTATGGAAGTTTGGGTCTTGAAGGCTACAACTAAG GAAAATTGGCAGTCGTGGGTCGATGCGTTACAAACTTGTTTTGACGATCAGTTCGAAGAT AAGGACACGTCCACTTTGGAAGAAAATCCCGACATTCTTGACGATGACAAGGAAGTAATT AATAAAAGCTCACCTCAAGACCACGACCACCTCACGCCCACGGCTACGACCAAAAGTGCA CTATCACATAGACAGCATACTCAGAAAGACATGGATGACATATATGTCCCATTGCCCAGC GAATCTTACGCTACTTTCTCCATGAATCTACGTTTGATTCAACAACGACTGGAGCAGTGT AAAAAAGACTCGTTATCTTATAAACCAACTACTTTACATCAAAGATCGGAGGGGCTAAAT GGAACACATTCGTCATCTTCCGTCTTTACCAATAATAGAGTGTCTTCATTCAATCATTCT TCTTCTGGTATGACGTCATCTGATTCTTTAGCCTCTGAAGAGGTTCCTTCCAACAAAACA TATATTGAGCATGCTTTATATAACCAATTGGCAGATCTTGAAGTATTTGTTAGCCGGTTC GTTACACAGGGAGAGGTTTTATTCAAGGACCACCAGATCCTGTGCAAGAAAGCAAAAGAC ACGAGAGTTTCTTTAACTTCATATCTTAGCGAGAATGATGAATTTTTTGATGCAGAAGAG GAAATCAGTCGGGGAGTCATTATATTACCTGACACAGAAGATGATATTAATAATATAGTC GAGGAAACTCCCCTTCTTGGTAAAAGTGACCAAAATGAGTTCACAAAAGAGGTCCAATTG TCGGGATCCGAACAGATAGCTTCATCAAGTGTGGAGAGCTATACAACTAACGATGAAAAT CATAGCCGTAAACACCTCAAAAATCGTCACAAAAATCGTCGCCGTGGCCACCCTCATCAT CAAAAAACCAAAAGCGCCCAATCCTCAACAGAAACATTTACAAGTAAGGATTTGTTTGCT CTTTCCTATCCAAAGAGTGTTACACGCCGTAATGACATACCTGAAGCTGCAGCTTCTCCG CCAAGCCTATTATCTTTTTTGAGAAAGAATGTAGGCAAAGATCTGAGCTCTATTGCCATG CCAGTAACCTCAAATGAGCCTATTTCTATTTTGCAGTTGATATCAGAAACATTTGAGTAT GCTCCACTTTTAACGAAGGCTACCCAACGTCCTGATCCTATAACCTTTGTTTCTGCATTT GCTATTTCCTTTCTTTCCATATATAGGGATAAAACAAGAACGCTAAGAAAGCCTTTTAAT CCTTTACTGGCTGAAACATTTGAACTTATACGAGAAGATATGGGGTTTAGGCTTATATCG GAAAAGGTCTCACATCGTCCTCCAGTATTTGCCTTCTTTGCAGAGCATCTCGACTGGGAG TGTAGTTACACTGTAACGCCATCGCAAAAGTTTTGGGGTAAGTCTATTGAATTGAATAAC GAAGGTATACTGAGATTGAAGTTTAAGACAACTGGAGAACTATTTGAATGGACGCAACCA ACAACTATTTTAAAAAATTTGATAGCGGGTGAGAGATATATGGAGCCTGTCAACGAATTC GAAGTACATTCTTCGAAGGGAGACAAATCACACATCCTGTTCGATAAGGCAGGTATGTTT AGTGGAAGATCTGAAGGATTTAAGGTTTCGATAATCCCACCACCTTCGAGCAATCGCAAG AAGGAAACTCTAGCTGGTAAATGGACACAGAGTTTAGCTAATGAAACTACACATGAAACT ATATGGGAAGTAGGTGATTTAGTTAGCAATCCGAAGAAGAAATATGGCTTTACTAAATTC ACCGCAAATTTGAATGAGATAACTGAAATTGAAAAGGGCAATTTACCACCTACGGACTCA AGATTAAGACCAGATATTAGAGCTTACGAGGAGGGAAATGTTGATAAGGCGGAAGAGTGG AAGCTGAAATTGGAACAACTTCAACGTGAAAGACGTAATAAAGGGCAAGATGTGGAGCCT AAATATTTCGAAAAAGTATCTAAGAATGAATGGAAATACATAACTGGACCGAAGAGTTAT TGGGAAAGAAGAAAGAAGCATGATTGGTCTGATATTTCTCAACTCTGGTGA
Protein Properties
Pfam Domain Function
Protein Residues996
Protein Molecular Weight113759.0
Protein Theoretical pI8.94
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Oxysterol-binding protein homolog 3 METIDIQNRSFVVRWVKCGRGDVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDT KTLLDYTTKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQ EIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFN ASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFK KRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDKIIIIDSGMEVWVLKATTK ENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSA LSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLN GTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRF VTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIV EETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHH QKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAASPPSLLSFLRKNVGKDLSSIAM PVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYRDKTRTLRKPFN PLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNN EGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMF SGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLANETTHETIWEVGDLVSNPKKKYGFTKF TANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERRNKGQDVEP KYFEKVSKNEWKYITGPKSYWERRKKHDWSDISQLW
References
External Links
ResourceLink
Saccharomyces Genome Database OSH3
Uniprot IDP38713
Uniprot NameOSH3_YEAST
GenBank Gene IDU10556
Genebank Protein ID500833
General Reference
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Levine, T. P., Munro, S. (2001). "Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction." Mol Biol Cell 12:1633-1644.11408574
  • Beh, C. T., Cool, L., Phillips, J., Rine, J. (2001). "Overlapping functions of the yeast oxysterol-binding protein homologues." Genetics 157:1117-1140.11238399
  • Loewen, C. J., Roy, A., Levine, T. P. (2003). "A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP." EMBO J 22:2025-2035.12727870
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956