GTPase-activating protein BEM3 (P32873)

Identification
NameGTPase-activating protein BEM3
Synonyms
  • Bud emergence protein 3
Gene NameBEM3
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction
Specific FunctionGTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
cytoplasm
cellular bud tip
incipient cellular bud site
mating projection tip
septin ring organization
cell cortex
GTPase activator activity
signal transduction
negative regulation of Rho protein signal transduction
establishment of cell polarity
phosphatidylinositol-3-phosphate binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>3387 bp ATGACAGATAATTTGACCACAACTCATGGTGGTAGTACCACCCTTGAATTGTTGGCGCAG TACAATGATCATAGATCCAAAAAGGACAAATCTATAGAACATATAGAAAAAGGAACATGT TCAGGAAAAGAAAGAAATCCGTCCTATGATGAAATTTTTACGGAAAACATTAAGCTAAAG CTACAAGTCCAAGAATATGAAACTGAAATTGAGAGTTTGGAAAAGGTTATTGATATGTTA CAAAAAAACAGAGAAGCTTCCTTAGAAGTTGTGCTTGAGCAAGTTCAAAATGACTCAAGA GATTCATACGTTAACGATCAATCATTTGTGTTACCCCCAAGATCTGCTGAAAGGAAAGCG CATATCAAGAGTCTTAATTTGCCAATACCGACATTGTCCCCTCCATTGCAACAAGGTTCA GACGTTGCACTTGAAACAAGTGTAACGCCTACAGTACCTCAAATAGGTGTTACATCAAAT ACTTCAATAAGTAGGAAGCATTTACAGAACATGATACTAAACGATGAAATAGAAGCAAAT AGTAGCTTCTCATCTCCCAAAATTATCAATAGATCTGTCTCAAGCCCTACAAAAATACAT TCAGAACAGTTGGCTAGCCCAGCTGCCTCTGTTACCTATACGACGTCTAGGATAACCATA AAATCACCTAATAAAGGTTCGAAATCTCCATTGCAAGAACGTTTGCGTTCCCCTCAAAAT CCTAACAGAATGACGGCTGTTATCAACAACCATTTGCATTCTCCATTAAAGGCCAGTACC TCTAATAATTTAGATGAGCTGACTGAAAGTAAAAGTCAACAACTAACTAATGACGCGATA CAAAAAAATGACCGCGTTTATTCTTCTATAACATCCTCTGCATACACTACTGGAACTCCT ACTTCAGCAGCCAAAAGTCCATCATCCCTTTTGGAAGTCAAGGAGGGTGAAAACAAGGCT TTGGGTTTCTCTCCAGCATCTAAAGAAAAACTTGACGACTTCACCCAATTACTTGACTCC TCATTTGGCGAAGAGGATCTAGTCAATACGGACAGTAAAGATCCTCTGTCCATAAAATCC ACGATTAACGAATCTTTACCCCCACCTCCAGCGCCTCCAACTTTTTTCTCACCTACTTCT AGTGGAAATATAAAAAACTCTACTCCTTTATCAAGCCATTTGGCTTCTCCGGTTATCTTG AATAAAAAGGATGATAATTTTGGTGCTCAAAGTGCAAAAAATTTAAAGAAACCTGTGTTA ACTTCATCACTCCCCAATCTTTCTACAAAATTGTCAACAACAAGTCAAAATGCTTCTCTT CCTCCAAATCCTCCCGTGGAAAGTTCATCAAAACAAAAACAACTTGGAGAAACGGCATCC ATCCATTCAACCAATACCTTGAATACATTTAGCTCAACACCCCAAGGTTCGTTGAAGACA CTTAGAAGACCTCATGCAAGTAGCGTGAGCACCGTGAAGTCTGTGGCCCAAAGTCTTAAG TCGGATATTCCATTATTCGTTCAACCGGAGGATTTTGGCACTATCCAGATTGAAGTACTG AGCACATTGTACAGGGATAATGAAGATGATTTATCCATTTTAATTGCAATCATAGACAGG AAATCCGGTAAGGAGATGTTTAAATTTTCAAAATCTATTCATAAAGTTCGCGAATTAGAT GTATATATGAAATCACATGTTCCCGATTTACCATTGCCCACGTTACCTGATAGACAATTA TTTCAGACTTTATCACCTACAAAAGTGGATACGCGAAAGAACATATTGAATCAGTATTAT ACAAGCATATTCAGTGTCCCTGAATTTCCCAAAAATGTTGGTTTAAAAATCGCCCAATTT ATTAGTACAGATACAGTAATGACACCTCCAATGATGGATGATAATGTGAAAGACGGATCA CTTTTGCTGAGAAGACCAAAGACTCTAACAGGTAATAGTACATGGAGAGTTCGGTACGGT ATTTTGCGCGATGATGTTTTACAATTGTTTGACAAAAATCAGTTGACTGAAACTATTAAA TTGAGACAATCTTCTATAGAACTTATACCCAATCTCCCTGAAGATAGATTTGGAACGAGA AATGGGTTTTTGATCACTGAGCATAAGAAAAGCGGACTGTCAACCTCAACAAAGTATTAT ATTTGTACTGAAACGTCGAAGGAACGTGAATTATGGCTTTCTGCGTTTAGTGATTACATT GATCCTTCACAAAGTTTATCGTTATCTAGCTCGAGGAATGCAAACGATACTGATTCTGCA TCTCACTTGAGCGCAGGAACACACCATTCTAAATTTGGAAACGCAACTATCTCAGCAACC GATACTCCATCATATGTCACTGATTTGACCCAAGAATATAATAATAATAACAATATTAGT AATAGTAGCAATAACATTGCTAATAGCGATGGTATTGACTCAAACCCATCTTCTCACTCT AACTTCCTAGCAAGTTCAAGCGGGAATGCAGAGGAGGAGAAGGATAGTAGGAGAGCCAAA ATGAGAAGTTTATTCCCTTTTAAAAAATTAACCGGCCCGGCGAGTGCAATGAACCATATA GGTATTACAATTTCAAATGATTCGGATTCTCCAACATCTCCTGACTCTATCATTAAGTCA CCAAGCAAAAAATTAATGGAAGTATCCTCTTCGTCAAATTCTTCTACGGGTCCACATGTG TCCACTGCAATATTTGGCTCGTCACTAGAAACGTGTTTAAGATTGAGTTCGCATAAGTAC CAAAACGTTTACGATTTACCGAGTGTAGTTTATCGTTGCTTAGAGTATCTTTACAAAAAC CGTGGTATCCAGGAAGAAGGCATATTTAGACTAAGCGGGTCCAGTACAGTTATCAAAACT TTACAAGAAAGGTTTGATAAAGAGTACGATGTAGATTTATGTCGGTACAATGAAAGTATT GAAGCTAAAGATGATGAGGCATCTCCAAGTCTTTACATTGGTGTGAATACTGTAAGTGGG TTACTAAAGTTGTACTTGAGAAAGTTGCCCCATTTATTATTTGGTGACGAACAATTTTTG TCGTTTAAAAGAGTAGTTGATGAAAATCATAATAATCCTGTTCAAATATCATTGGGGTTT AAGGAACTTATTGAATCTGGCCTAGTTCCTCACGCTAACCTATCGTTGATGTATGCTCTT TTTGAACTGCTGGTAAGGATCAATGAGAATAGTAAGTTTAATAAGATGAATCTAAGAAAT TTATGCATCGTGTTTTCCCCAACTCTAAATATTCCAATTAGTATGCTTCAACCATTCATC ACTGACTTTGCGTGTATATTTCAGGGTGGTGAACCAGTTAAAGAAGAGGAAAGGGAGAAA GTAGATATACATATTCCTCAGGTTTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1128
Protein Molecular Weight124911.845
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>GTPase-activating protein BEM3 MTDNLTTTHGGSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKERNPSYDEIFTENIKLK LQVQEYETEIESLEKVIDMLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKA HIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEAN SSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRITIKSPNKGSKSPLQERLRSPQN PNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAYTTGTP TSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDPLSIKS TINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLASPVILNKKDDNFGAQSAKNLKKPVL TSSLPNLSTKLSTTSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQGSLKT LRRPHASSVSTVKSVAQSLKSDIPLFVQPEDFGTIQIEVLSTLYRDNEDDLSILIAIIDR KSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYY TSIFSVPEFPKNVGLKIAQFISTDTVMTPPMMDDNVKDGSLLLRRPKTLTGNSTWRVRYG ILRDDVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYY ICTETSKERELWLSAFSDYIDPSQSLSLSSSRNANDTDSASHLSAGTHHSKFGNATISAT DTPSYVTDLTQEYNNNNNISNSSNNIANSDGIDSNPSSHSNFLASSSGNAEEEKDSRRAK MRSLFPFKKLTGPASAMNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHV STAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKT LQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFL SFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMNLRN LCIVFSPTLNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV
References
External Links
ResourceLink
Saccharomyces Genome Database BEM3
Uniprot IDP32873
Uniprot NameBEM3
General ReferenceNot Available