Protein STE12 (P13574)

Identification
NameProtein STE12
SynonymsNot Available
Gene NameSTE12
Enzyme ClassNot Available
Biological Properties
General Functiontranscription, DNA-templated
Specific FunctionBinds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
nucleus
invasive growth in response to glucose limitation
pseudohyphal growth
DNA binding
nucleoplasm
Ste12p-Dig1p-Dig2p complex
Tec1p-Ste12p-Dig1p complex
transcription factor activity, sequence-specific DNA binding
conjugation with cellular fusion
negative regulation of transcription from RNA polymerase II promoter by pheromones
positive regulation of transcription from RNA polymerase II promoter by pheromones
transcription, DNA-templated
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2067 bp ATGAAAGTCCAAATAACCAATAGTAGAACAGAGGAAATCTTAAAAGTTCAAGCTAATAAT GAAAACGATGAAGTCAGTAAAGCTACTCCGGGCGAAGTTGAAGAATCGCTAAGGTTAATC GGCGATCTAAAATTCTTTTTAGCCACAGCGCCGGTAAATTGGCAAGAAAACCAAATTATA AGGCGATACTATCTGAATAGTGGACAAGGCTTTGTCTCTTGTGTATTTTGGAACAATCTA TACTATATTACAGGTACTGATATTGTCAAATGTTGTCTTTACAGAATGCAAAAGTTTGGG AGAGAAGTAGTTCAAAAGAAAAAATTTGAAGAGGGTATTTTTTCAGATTTAAGAAATCTC AAATGTGGTATAGATGCAACTTTAGAACAACCAAAGTCCGAATTTTTGTCGTTTCTATTC AGAAATATGTGTCTGAAAACCCAAAAAAAGCAGAAAGTATTTTTTTGGTTCAGTGTAGCA CATGATAAGTTGTTTGCGGATGCGTTGGAAAGAGATTTAAAAAGAGAAAGTTTGAATCAG CCTTCAACGACTAAGCCCGTTAATGAGCCCGCCTTATCTTTTTCATATGATTCCTCATCT GATAAGCCTCTCTACGATCAGTTACTTCAACATTTAGATTCTAGAAGACCATCTAGTACA ACAAAATCAGATAATTCGCCTCCAAAATTAGAAAGCGAGAATTTTAAGGATAATGAGTTG GTAACAGTAACTAATCAGCCGCTTTTAGGCGTTGGCCTCATGGATGACGATGCGCCAGAA TCCCCCTCTCAAATTAATGATTTTATTCCTCAGAAATTGATTATAGAACCCAATACTCTC GAATTGAATGGTCTCACAGAAGAAACGCCTCATGACTTACCCAAGAATACCGCTAAGGGC AGAGACGAAGAAGATTTTCCTCTCGACTATTTTCCTGTATCTGTTGAATACCCTACGGAG GAAAATGCGTTTGATCCGTTCCCTCCACAGGCTTTTACGCCAGCTGCCCCTTCCATGCCT ATTTCCTATGATAACGTGAATGAAAGGGATTCTATGCCCGTTAATTCTCTTCTTAATAGA TACCCCTATCAGTTATCAGTGGCACCCACTTTCCCAGTGCCACCATCATCATCGAGGCAA CATTTTATGACAAATCGGGATTTTTATTCATCTAACAATAACAAGGAAAAATTGGTATCT CCTAGCGACCCTACCAGCTACATGAAGTATGACGAACCAGTTATGGATTTTGATGAATCT CGGCCAAATGAAAACTGTACAAATGCAAAATCTCACAACTCTGGCCAGCAAACTAAACAA CACCAATTATATTCTAACAACTTCCAGCAATCTTACCCAAACGGAATGGTTCCAGGATAC TACCCAAAAATGCCGTATAATCCCATGGGGGGGGATCCTCTACTCGATCAAGCCTTTTAT GGCGCGGACGATTTTTTCTTTCCACCAGAAGGATGTGATAACAATATGCTGTATCCACAA ACTGCAACTTCATGGAATGTTTTGCCCCCTCAAGCTATGCAACCAGCTCCAACCTATGTT GGGAGACCATACACACCGAATTATAGATCGACACCAGGTTCCGCGATGTTCCCATACATG CAAAGTTCAAATTCCATGCAGTGGAACACTGCTGTTTCACCTTATAGTTCGAGAGCACCA TCTACAACTGCTAAAAACTATCCTCCTAGCACATTTTATTCTCAAAATATAAATCAATAC CCACGGCGAAGAACTGTGGGAATGAAGTCTTCACAAGGAAATGTTCCAACAGGTAATAAA CAATCTGTGGGCAAGTCTGCAAAAATTTCAAAGCCTCTACATATTAAGACAAGTGCTTAT CAGAAGCAATACAAAATCAACTTGGAAACGAAAGCCAGGCCAAGTGCTGGTGACGAAGAT TCTGCTCATCCTGATAAGAACAAAGAAATTTCGATGCCTACTCCGGATTCCAATACTTTG GTGGTCCAGTCAGAAGAAGGTGGAGCTCATTCACTTGAGGTAGATACCAATCGAAGGTCC GATAAAAACCTTCCAGATGCAACCTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues688
Protein Molecular Weight77866.175
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Protein STE12 MKVQITNSRTEEILKVQANNENDEVSKATPGEVEESLRLIGDLKFFLATAPVNWQENQII RRYYLNSGQGFVSCVFWNNLYYITGTDIVKCCLYRMQKFGREVVQKKKFEEGIFSDLRNL KCGIDATLEQPKSEFLSFLFRNMCLKTQKKQKVFFWFSVAHDKLFADALERDLKRESLNQ PSTTKPVNEPALSFSYDSSSDKPLYDQLLQHLDSRRPSSTTKSDNSPPKLESENFKDNEL VTVTNQPLLGVGLMDDDAPESPSQINDFIPQKLIIEPNTLELNGLTEETPHDLPKNTAKG RDEEDFPLDYFPVSVEYPTEENAFDPFPPQAFTPAAPSMPISYDNVNERDSMPVNSLLNR YPYQLSVAPTFPVPPSSSRQHFMTNRDFYSSNNNKEKLVSPSDPTSYMKYDEPVMDFDES RPNENCTNAKSHNSGQQTKQHQLYSNNFQQSYPNGMVPGYYPKMPYNPMGGDPLLDQAFY GADDFFFPPEGCDNNMLYPQTATSWNVLPPQAMQPAPTYVGRPYTPNYRSTPGSAMFPYM QSSNSMQWNTAVSPYSSRAPSTTAKNYPPSTFYSQNINQYPRRRTVGMKSSQGNVPTGNK QSVGKSAKISKPLHIKTSAYQKQYKINLETKARPSAGDEDSAHPDKNKEISMPTPDSNTL VVQSEEGGAHSLEVDTNRRSDKNLPDAT
References
External Links
ResourceLink
Saccharomyces Genome Database STE12
Uniprot IDP13574
Uniprot NameSTE12
PDB ID
3W3W
General ReferenceNot Available