Barrierpepsin (P12630)

Identification
NameBarrierpepsin
Synonyms
  • BAR proteinase
  • Extracellular 'barrier' protein
Gene NameBAR1
Enzyme ClassNot Available
Biological Properties
General Functionprotein catabolic process
Specific FunctionThis protein called "barrier activity" is excreted by yeast cells mating type a. It is probably a protease that cleaves alpha-factor and thus acts as an antagonist of this mating pheromone and establishes optimal pheromone concentration for conjugation.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
extracellular region
adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
cell wall-bounded periplasmic space
aspartic-type endopeptidase activity
peptide catabolic process
protein catabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1764 bp ATGTCTGCAATTAATCATCTTTGTTTGAAACTTATTTTGGCGAGTTTCGCGATTATTAAC ACCATTACTGCTTTAACAAACGATGGCACTGGTCACTTAGAATTCCTTTTACAACACGAA GAGGAGATGTATTACGCAACAACCTTAGATATAGGTACACCGTCCCAAAGTCTGACAGTG TTGTTTGATACCGGATCTGCCGATTTTTGGGTTATGGATTCTAGCAATCCCTTCTGCTTA CCAAATTCAAATACGTCATCCTATTCAAACGCAACTTATAATGGCGAAGAAGTTAAGCCT TCAATTGATTGCAGGTCTATGAGTACTTATAATGAGCATAGATCTTCCACCTACCAATAT CTGGAAAATGGTAGGTTTTACATCACATATGCTGACGGAACATTTGCTGACGGTAGTTGG GGGACGGAAACTGTATCAATTAATGGAATTGACATCCCCAATATCCAGTTCGGAGTTGCC AAGTATGCTACGACACCCGTTAGTGGTGTTCTTGGAATTGGGTTTCCTAGAAGAGAGTCC GTTAAGGGCTATGAAGGTGCTCCTAATGAATATTATCCTAATTTTCCTCAGATTTTAAAA AGTGAAAAAATAATCGATGTGGTCGCGTATTCGCTGTTCTTAAACTCACCTGATTCAGGT ACTGGTTCGATTGTTTTTGGTGCCATTGATGAATCAAAGTTTTCTGGTGATTTGTTCACT TTCCCTATGGTAAATGAATATCCCACAATAGTCGACGCTCCTGCAACTTTAGCAATGACT ATACAAGGATTAGGTGCCCAAAACAAAAGTAGTTGTGAACATGAAACGTTTACGACGACC AAGTATCCAGTTTTGTTGGACTCAGGAACCTCGCTATTGAATGCGCCCAAGGTCATAGCA GATAAAATGGCTTCTTTTGTAAATGCGTCCTATAGTGAAGAGGAAGGTATATATATATTA GACTGTCCAGTATCTGTAGGTGACGTGGAATACAATTTTGATTTCGGCGATTTGCAAATA AGTGTTCCACTGTCTAGTTTGATTTTAAGTCCCGAGACAGAAGGCAGCTATTGTGGGTTT GCGGTCCAGCCAACAAACGATTCGATGGTTCTGGGTGATGTGTTCCTGTCCTCTGCATAC GTCGTATTCGATCTCGATAATTATAAGATATCTTTAGCACAGGCAAATTGGAACGCAAGC GAAGTTTCGAAAAAGCTAGTAAATATTCAAACAGATGGGTCTATTTCAGGTGCCAAAATT GCTACAGCTGAACCCTGGTCCACCAATGAACCATTTACAGTCACCTCTGACATTTATTCA TCTACAGGCTGCAAGAGTAGGCCTTTTCTTCAATCATCGACAGCCTCTTCGCTTATTGCA GAAACCAACGTACAAAGTCGCAACTGCTCTACGAAGATGCCAGGCACTAGATCAACTACT GTCTTAAGTAAGCCTACTCAAAATAGTGCTATGCATCAAAGTACAGGCGCTGTCACACAA ACCTCAAATGAAACTAAATTAGAATTATCCTCGACTATGGCAAATTCGGGCAGTGTCTCG CTTCCCACTTCGAATTCAATAGACAAAGAGTTCGAACATTCGAAATCTCAAACTACCAGC GATCCAAGTGTAGCAGAGCATTCTACGTTTAACCAAACGTTTGTACATGAAACTAAATAT CGGCCTACTCATAAGACAGTCATAACAGAAACTGTCACGAAGTATTCTACAGTCTTAATA AATGTCTGTAAACCAACATATTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues587
Protein Molecular Weight63729.29
Protein Theoretical pINot Available
Signalling Regions
  • 1-24
Transmembrane RegionsNot Available
Protein Sequence>Barrierpepsin MSAINHLCLKLILASFAIINTITALTNDGTGHLEFLLQHEEEMYYATTLDIGTPSQSLTV LFDTGSADFWVMDSSNPFCLPNSNTSSYSNATYNGEEVKPSIDCRSMSTYNEHRSSTYQY LENGRFYITYADGTFADGSWGTETVSINGIDIPNIQFGVAKYATTPVSGVLGIGFPRRES VKGYEGAPNEYYPNFPQILKSEKIIDVVAYSLFLNSPDSGTGSIVFGAIDESKFSGDLFT FPMVNEYPTIVDAPATLAMTIQGLGAQNKSSCEHETFTTTKYPVLLDSGTSLLNAPKVIA DKMASFVNASYSEEEGIYILDCPVSVGDVEYNFDFGDLQISVPLSSLILSPETEGSYCGF AVQPTNDSMVLGDVFLSSAYVVFDLDNYKISLAQANWNASEVSKKLVNIQTDGSISGAKI ATAEPWSTNEPFTVTSDIYSSTGCKSRPFLQSSTASSLIAETNVQSRNCSTKMPGTRSTT VLSKPTQNSAMHQSTGAVTQTSNETKLELSSTMANSGSVSLPTSNSIDKEFEHSKSQTTS DPSVAEHSTFNQTFVHETKYRPTHKTVITETVTKYSTVLINVCKPTY
References
External Links
ResourceLink
Saccharomyces Genome Database BAR1
Uniprot IDP12630
Uniprot NameBAR1
General ReferenceNot Available