Cytochrome c heme lyase (P06182)

Identification
NameCytochrome c heme lyase
Synonyms
  • CCHL
  • Holocytochrome-c synthase
Gene NameCYC3
Enzyme Class
Biological Properties
General FunctionInvolved in holocytochrome-c synthase activity
Specific FunctionLinks covalently the heme group to the apoprotein of cytochrome c
Cellular LocationMitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG Pathways
Porphyrin and chlorophyll metabolismec00860 Map00860
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00041HemeShow
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
mitochondrion
Function
catalytic activity
lyase activity
carbon-sulfur lyase activity
holocytochrome-c synthase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 1
LocusYAL039C
Gene Sequence>810 bp ATGGGTTGGTTTTGGGCAGATCAAAAAACTACGGGCAAAGATATTGGTGGGGCAGCAGTA TCATCCATGTCAGGGTGCCCAGTCATGCACGAGTCGTCGTCGTCGTCGCCACCATCCTCT GAGTGCCCCGTTATGCAGGGAGATAACGATAGAATAAACCCGCTGAACAATATGCCGGAG TTGGCAGCATCCAAACAGCCTGGCCAAAAGATGGACTTGCCCGTTGATCGGACCATCTCC AGCATCCCCAAGAGTCCAGACAGTAACGAGTTCTGGGAGTATCCTTCTCCACAACAGATG TACAATGCTATGGTTAGAAAGGGCAAGATTGGCGGTAGCGGCGAAGTCGCCGAAGATGCA GTGGAGTCCATGGTGCAGGTCCACAACTTTCTAAATGAAGGGTGCTGGCAGGAAGTGCTC GAATGGGAAAAACCGCACACAGATGAAAGCCACGTGCAGCCTAAGTTGCTGAAATTCATG GGGAAACCGGGCGTATTGAGCCCTCGTGCTCGCTGGATGCACCTGTGCGGCCTACTGTTT CCGTCCCATTTTAGCCAAGAACTACCATTCGACAGGCACGACTGGATTGTACTCCGAGGC GAGCGCAAAGCGGAACAACAACCTCCAACCTTCAAGGAAGTTAGATACGTCTTGGATTTC TACGGAGGGCCCGACGACGAAAACGGAATGCCTACTTTCCACGTGGATGTCCGTCCTGCC CTAGATAGTCTAGACAATGCTAAGGACCGGATGACCCGTTTCTTGGACCGGATGATCTCG GGTCCGTCCTCTTCGTCCTCCGCCCCTTAA
Protein Properties
Pfam Domain Function
Protein Residues269
Protein Molecular Weight30080.69922
Protein Theoretical pI5.18
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome c heme lyase MGWFWADQKTTGKDIGGAAVSSMSGCPVMHESSSSSPPSSECPVMQGDNDRINPLNNMPE LAASKQPGQKMDLPVDRTISSIPKSPDSNEFWEYPSPQQMYNAMVRKGKIGGSGEVAEDA VESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLF PSHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPA LDSLDNAKDRMTRFLDRMISGPSSSSSAP
References
External Links
ResourceLink
Saccharomyces Genome Database CYC3
Uniprot IDP06182
Uniprot NameCCHL_YEAST
GenBank Gene IDU12980
Genebank Protein ID595545
General Reference
  • Dumont, M. E., Ernst, J. F., Hampsey, D. M., Sherman, F. (1987). "Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae." EMBO J 6:235-241.3034577
  • Bussey, H., Kaback, D. B., Zhong, W., Vo, D. T., Clark, M. W., Fortin, N., Hall, J., Ouellette, B. F., Keng, T., Barton, A. B., et, a. l. .. (1995). "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A 92:3809-3813.7731988
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106