ATP synthase protein 8 (P00856)

Identification
NameATP synthase protein 8
Synonyms
  • A6L
  • ATP-associated protein 1
  • F-ATPase subunit 8
Gene NameATP8
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in hydrogen ion transmembrane transporter acti
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane
Cellular LocationMitochondrion membrane; Single-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
membrane part
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
mitochondrial membrane part
cell part
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
metabolic process
purine nucleotide metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>147 bp ATGCCACAATTAGTTCCATTTTATTTTATGAATCAATTAACATATGGTTTCTTATTAATG ATTCTATTATTAATTTTATTCTCACAATTCTTTTTACCTATGATCTTAAGATTATATGTA TCTAGATTATTTATTTCTAAATTATAA
Protein Properties
Pfam Domain Function
Protein Residues48
Protein Molecular Weight5822.2002
Protein Theoretical pI10.27
Signalling Regions
  • None
Transmembrane Regions
  • 13-32
Protein Sequence>ATP synthase protein 8 MPQLVPFYFMNQLTYGFLLMITLLILFSQFFLPMILRLYVSRLFISKL
References
External Links
ResourceLink
Saccharomyces Genome Database ATP8
Uniprot IDP00856
Uniprot NameATP8_YEAST
GenBank Gene IDAJ011856
Genebank Protein ID4160373
General Reference
  • Macreadie, I. G., Novitski, C. E., Maxwell, R. J., John, U., Ooi, B. G., McMullen, G. L., Lukins, H. B., Linnane, A. W., Nagley, P. (1983). "Biogenesis of mitochondria: the mitochondrial gene (aap1) coding for mitochondrial ATPase subunit 8 in Saccharomyces cerevisiae." Nucleic Acids Res 11:4435-4451.6223276
  • Simon, M., Faye, G. (1984). "Organization and processing of the mitochondrial oxi3/oli2 multigenic transcript in yeast." Mol Gen Genet 196:266-274.6387398
  • Foury, F., Roganti, T., Lecrenier, N., Purnelle, B. (1998). "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae." FEBS Lett 440:325-331.9872396