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Identification
NameCyclin-dependent kinase 1
Synonyms
  • CDK1
  • Cell division control protein 28
  • Cell division protein kinase 1
Gene NameCDC28
Enzyme ClassNot Available
Biological Properties
General Functionvesicle-mediated transport
Specific FunctionThis protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
negative regulation of mitotic cell cycle
protein phosphorylation involved in DNA double-strand break processing
ATP binding
nucleus
negative regulation of sister chromatid cohesion
protein phosphorylation involved in double-strand break repair via nonhomologous end joining
cellular bud neck
negative regulation of transcription from RNA polymerase II promoter during mitosis
protein phosphorylation involved in mitotic spindle assembly
cyclin-dependent protein kinase holoenzyme complex
negative regulation of transcription, DNA-templated
protein phosphorylation involved in protein localization to spindle microtubule
cytoplasm
peptidyl-serine phosphorylation
regulation of budding cell apical bud growth
endoplasmic reticulum
phosphorylation of RNA polymerase II C-terminal domain
regulation of double-strand break repair via homologous recombination
cyclin-dependent protein serine/threonine kinase activity
positive regulation of meiotic cell cycle
regulation of filamentous growth
histone binding
positive regulation of mitotic cell cycle
regulation of nucleosome density
protein serine/threonine kinase activity
positive regulation of nuclear cell cycle DNA replication
regulation of spindle assembly
RNA polymerase II core binding
positive regulation of spindle pole body separation
regulation of telomere maintenance via telomerase
7-methylguanosine mRNA capping
positive regulation of transcription from RNA polymerase II promoter
synaptonemal complex assembly
vesicle-mediated transport
cell division
positive regulation of transcription, DNA-templated
meiotic DNA double-strand break processing
positive regulation of triglyceride catabolic process
mitotic sister chromatid biorientation
protein localization to nuclear periphery
negative regulation of double-strand break repair via nonhomologous end joining
protein localization to nucleus
negative regulation of meiotic cell cycle
protein phosphorylation involved in cellular protein catabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>897 bp ATGAGCGGTGAATTAGCAAATTACAAAAGACTTGAGAAAGTCGGTGAAGGTACATACGGT GTTGTTTATAAAGCGTTAGACTTAAGACCTGGCCAAGGTCAAAGAGTAGTCGCATTGAAG AAAATAAGACTAGAGAGTGAAGACGAGGGTGTTCCCAGTACAGCCATCAGAGAAATCTCA TTATTGAAGGAATTAAAAGACGATAATATTGTCAGATTATACGATATTGTTCACTCTGAT GCACACAAGCTATATCTTGTTTTTGAGTTCCTCGATTTGGACCTGAAAAGATATATGGAG GGTATTCCAAAGGACCAACCGTTAGGAGCTGATATTGTTAAGAAGTTTATGATGCAACTT TGTAAGGGTATTGCATACTGCCACTCACACCGTATTCTGCATCGTGATTTAAAACCGCAG AACTTATTGATTAACAAAGATGGGAATCTAAAACTAGGTGATTTTGGCTTAGCGCGTGCT TTTGGTGTTCCGTTGAGAGCTTACACACATGAAATTGTTACTCTATGGTATAGAGCTCCG GAGGTATTACTGGGTGGAAAACAATATAGTACAGGTGTCGATACATGGTCCATCGGCTGT ATATTTGCCGAAATGTGTAACAGGAAACCAATCTTCAGTGGCGATAGTGAGATCGATCAG ATTTTCAAGATATTCAGAGTATTGGGAACGCCGAATGAAGCTATATGGCCAGATATTGTC TACTTGCCTGATTTCAAGCCAAGCTTTCCTCAATGGCGCAGAAAAGACCTATCACAAGTG GTACCAAGTCTAGATCCACGCGGTATTGATTTGTTGGACAAACTCCTCGCGTATGACCCT ATTAACCGGATTAGCGCCAGAAGAGCAGCCATCCACCCCTACTTCCAAGAATCATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues298
Protein Molecular Weight34061.135
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Cyclin-dependent kinase 1 MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREIS LLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQL CKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAP EVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIV YLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES
References
External Links
ResourceLink
Saccharomyces Genome Database CDC28
Uniprot IDP00546
Uniprot NameCDC28
General ReferenceNot Available