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Cytochrome c oxidase subunit 6, mitochondrial (P00427)

Identification
NameCytochrome c oxidase subunit 6, mitochondrial
Synonyms
  • Cytochrome c oxidase polypeptide VI
Gene NameCOX6
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in cytochrome-c oxidase activity
Specific FunctionThis is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
Cellular LocationMitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
catalytic activity
oxidoreductase activity
heme-copper terminal oxidase activity
cytochrome-c oxidase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>447 bp ATGTTATCAAGGGCCATATTCAGAAATCCAGTTATAAATAGAACTTTATTGAGAGCCAGA CCTGGTGCTTATCATGCAACTAGATTGACTAAAAATACGTTTATTCAAAGTAGGAAGTAT TCTGACGCACATGATGAAGAAACCTTTGAGGAATTCACCGCAAGATACGAAAAGGAGTTT GATGAAGCCTATGATTTGTTTGAAGTGCAAAGAGTGCTCAACAACTGTTTTTCCTATGAT TTAGTTCCTGCTCCTGCTGTTATTGAAAAAGCTTTGAGGGCTGCCAGAAGAGTCAATGAC TTACCTACCGCAATTAGAGTATTTGAGGCTTTGAAATACAAGGTGGAGAATGAAGACCAA TACAAGGCCTACTTGGATGAATTGAAGGATGTCAGACAAGAATTGGGCGTTCCCTTAAAG GAAGAGCTATTTCCAAGCTCTTCTTAA
Protein Properties
Pfam Domain Function
Protein Residues148
Protein Molecular Weight17341.40039
Protein Theoretical pI5.86
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome c oxidase subunit 6, mitochondrial MLSRAIFRNPVINRTLLRARPGAYHATRLTKNTFIQSRKYSDAHDEETFEEFTARYEKEF DEAYDLFEVQRVLNNCFSYDLVPAPAVIEKALRAARRVNDLPTAIRVFEALKYKVENEDQ YKAYLDELKDVRQELGVPLKEELFPSSS
References
External Links
ResourceLink
Saccharomyces Genome Database COX6
Uniprot IDP00427
Uniprot NameCOX6_YEAST
GenBank Gene IDAY558278
Genebank Protein ID45270446
General Reference
  • Wright, R. M., Ko, C., Cumsky, M. G., Poyton, R. O. (1984). "Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae." J Biol Chem 259:15401-15407.6210289
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Wright, R. M., Rosenzweig, B., Poyton, R. O. (1989). "Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially." Nucleic Acids Res 17:1103-1120.2537949
  • Gregor, I., Tsugita, A. (1982). "The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae." J Biol Chem 257:13081-13087.6290493
  • Geier, B. M., Schagger, H., Ortwein, C., Link, T. A., Hagen, W. R., Brandt, U., Von Jagow, G. (1995). "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Eur J Biochem 227:296-302.7851399
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106