| Identification |
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| Name | Cytochrome b |
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| Synonyms | - Complex III subunit 3
- Complex III subunit CYTB
- Complex III subunit III
- Cytochrome b-c1 complex subunit 3
- Cytochrome b-c1 complex subunit CYTB
- Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
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| Gene Name | COB |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Energy production and conversion |
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| Specific Function | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c |
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| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | |
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| GO Classification | | Component |
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| cell part | | membrane | | Function |
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| catalytic activity | | oxidoreductase activity | | electron carrier activity | | Process |
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| metabolic process | | cellular metabolic process | | generation of precursor metabolites and energy | | electron transport chain | | respiratory electron transport chain |
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >1158 bp
ATGGCATTTAGAAAATCAAATGTGTATTTAAGTTTAGTGAATAGTTATATTATTGATTCA
CCACAACCATCATCAATTAATTATTGATGAAATATGGGTTCATTATTAGGTTTATGTTTA
GTTATTCAAATTGTAACAGGTATTTTTATGGCTATGCATTATTCATCTAATATTGAATTA
GCTTTTTCATCTGTTGAACATATTATAAGAGATGTGCATAATGGTTATATTTTAAGATAT
TTACATGCAAATGGTGCATCATTCTTTTTTATGGTAATGTTTATGCATATGGCTAAAGGT
TTATATTATGGTTCATATAGATCACCAAGAGTACTATTATGAAATGTAGGTGTTATTATT
TTCATTTTAACTATTGCTACAGCTTTTTTAGGTTATTGTTGTGTTTATGGACAGATGTCA
CATTGAGGTGCACTAGTTATTACTAATTTATTCTCAGCAATTCCATTTGTAGGTAACGAT
ATTGTATCTTGATTATGAGGTGGGTTCTCAGTATCTAACCCTCTAATCCAGAGATTCTTT
GCGTTACATTATTTAGTACCTTTTATCATTGCTGCAATGGTTATTATGCATTTAATGGCA
TTACATATTCATGGTTCATCTAATCCATTAGGTATTACAGGTAATTTAGATAGAATTCCA
ATGCATTCATACTTTATTTTTAAAGATTTAGTAACTGTTTTCTTATTTATGTTAATTTTA
GCATTATTTGTATTCTATTCACCTAATACTTTAGGTCATCCTGATAACTATATTCCTGGT
AATCCTTTAGTAACACCAGCATCTATTGTACCTGAATGATACTTATTACCATTCTATGCT
ATTTTAAGATCTATTCCTGATAAATTATTAGGAGTTATTCTAATGTTTGCAGCTATTTTA
GTATTATTAGTTTTACCATTTACTGATAGAAGTGTAGTAAGAGGTAATACTTTTAAAGTA
TTATCTAAATTCTTCTTCTTTATCTTTGTATTCAATTTCGTATTATTAGGACAAATTGGA
GCATGCCATGTAGAAGTACCTTATGTCTTAATGGGACAAATCGCTACATTTATCTACTTC
GCTTATTTCTTAATTATTGTACCTGTTATCTCTACTATTGAAAATGTTTTATTCTATATC
GGTAGAGTTAATAAATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 385 |
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| Protein Molecular Weight | 43655.5 |
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| Protein Theoretical pI | 8.93 |
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| PDB File | show |
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| Signalling Regions | |
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| Transmembrane Regions | - 32-52
- 85-105
- 116-136
- 151-171
- 179-199
- 225-245
- 289-309
- 324-344
- 350-370
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| Protein Sequence | >Cytochrome b
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIEL
AFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVII
FILTIATAFLGYCCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFSVSNPTIQRFF
ALHYLVPFIIAAMVIMHLMALHIHGSSNPLGITGNLDRIPMHSYFIFKDLVTVFLFMLIL
ALFVFYSPNTLGHPDNYIPGNPLVTPASIVPEWYLLPFYAILRSIPDKLLGVITMFAAIL
VLLVLPFTDRSVVRGNTFKVLSKFFFFIFVFNFVLLGQIGACHVEVPYVLMGQIATFIYF
AYFLIIVPVISTIENVLFYIGRVNK |
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| References |
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| External Links | |
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| General Reference | - Nobrega, F. G., Tzagoloff, A. (1980). "Assembly of the mitochondrial membrane system. DNA sequence and organization of the cytochrome b gene in Saccharomyces cerevisiae D273-10B." J Biol Chem 255:9828-9837.6253454
- Bonjardim, C. A., Nobrega, F. G. (1984). "Revision of the nucleotide sequence at the last intron of the mitochondrial apocytochrome b gene in Saccharomyces cerevisiae." Braz J Med Biol Res 17:17-20.6383504
- Claros, M. G., Perea, J., Shu, Y., Samatey, F. A., Popot, J. L., Jacq, C. (1995). "Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b." Eur J Biochem 228:762-771.7737175
- Foury, F., Roganti, T., Lecrenier, N., Purnelle, B. (1998). "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae." FEBS Lett 440:325-331.9872396
- Lazowska, J., Jacq, C., Slonimski, P. P. (1980). "Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron." Cell 22:333-348.7004642
- Lazowska, J., Jacq, C., Slonimski, P. P. (1981). "Splice points of the third intron in the yeast mitochondrial cytochrome b gene." Cell 27:12-14.7034963
- Brivet-Chevillotte, P., di Rago, J. P. (1989). "Electron-transfer restoration by vitamin K3 in a complex III-deficient mutant of S. cerevisiae and sequence of the corresponding cytochrome b mutation." FEBS Lett 255:5-9.2551731
- Hunte, C., Koepke, J., Lange, C., Rossmanith, T., Michel, H. (2000). "Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment." Structure 8:669-684.10873857
- Lange, C., Hunte, C. (2002). "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c." Proc Natl Acad Sci U S A 99:2800-2805.11880631
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