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Identification |
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Name | Mitochondrial distribution and morphology protein 35 |
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Synonyms | Not Available |
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Gene Name | MDM35 |
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Enzyme Class | Not Available |
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Biological Properties |
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General Function | protein targeting to mitochondrion |
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Specific Function | Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602). |
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Cellular Location | Not Available |
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SMPDB Pathways | Cardiolipin Biosynthesis | PW002431 | | Cardiolipin Biosynthesis CL(10:0/10:0/10:0/28:0) | PW003484 | | Cardiolipin Biosynthesis CL(10:0/10:0/10:0/30:0) | PW003501 | | Cardiolipin Biosynthesis CL(10:0/10:0/12:0/26:0) | PW003502 | | Cardiolipin Biosynthesis CL(10:0/10:0/12:0/28:0) | PW003503 | |
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KEGG Pathways | Not Available |
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SMPDB Reactions | Not Available |
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KEGG Reactions | Not Available |
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Metabolites | |
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GO Classification | Function |
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mitochondrial intermembrane space | nucleus | lipid transport | mitochondrial respiratory chain complex assembly | mitochondrion organization | protein targeting to mitochondrion |
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Gene Properties |
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Chromosome Location | Not Available |
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Locus | |
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Gene Sequence | >261 bp
ATGGGGAATATAATGTCAGCTAGTTTTGCGCCTGAATGCACTGACCTGAAGACGAAATAC
GATAGTTGTTTTAATGAATGGTATAGCGAAAAATTCCTGAAGGGAAAATCCGTTGAGAAC
GAGTGCTCAAAACAATGGTACGCTTATACTACATGTGTCAACGCAGCTCTCGTCAAACAA
GGTATTAAGCCTGCTCTAGACGAAGCTAGGGAGGAGGCGCCGTTTGAAAATGGCGGCAAA
CTAAAAGAAGTTGACAAATGA |
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Protein Properties |
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Pfam Domain Function | Not Available |
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Protein Residues | 86 |
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Protein Molecular Weight | 9711.885 |
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Protein Theoretical pI | Not Available |
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PDB File | show |
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Signalling Regions | Not Available |
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Transmembrane Regions | Not Available |
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Protein Sequence | >Mitochondrial distribution and morphology protein 35
MGNIMSASFAPECTDLKTKYDSCFNEWYSEKFLKGKSVENECSKQWYAYTTCVNAALVKQ
GIKPALDEAREEAPFENGGKLKEVDK |
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References |
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External Links | |
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General Reference | Not Available |
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