Showing Reaction 1612

PE(14:0/16:1(9Z)) + 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol ↔ 6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
Thumb+6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol↔6-O-{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol

Enzymes

  1. GPI ethanolamine phosphate transferase 1

Cellular Locations

  • endoplasmic reticulum

References

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  • Gaynor, E. C., Mondesert, G., Grimme, S. J., Reed, S. I., Orlean, P., Emr, S. D. (1999). "MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast." Mol Biol Cell 10:627-648.10069808
  • Storey, M. K., Wu, W. I., Voelker, D. R. (2001). "A genetic screen for ethanolamine auxotrophs in Saccharomyces cerevisiae identifies a novel mutation in Mcd4p, a protein implicated in glycosylphosphatidylinositol anchor synthesis." Biochim Biophys Acta 1532:234-247.11470244
  • Kalebina, T. S., Laurinavichiute, D. K., Packeiser, A. N., Morenkov, O. S., Ter-Avanesyan, M. D., Kulaev, I. S. (2002). "Correct GPI-anchor synthesis is required for the incorporation of endoglucanase/glucanosyltransferase Bgl2p into the Saccharomyces cerevisiae cell wall." FEMS Microbiol Lett 210:81-85.12023081
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  • Kinoshita, T., Inoue, N. (2000). "Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis." Curr Opin Chem Biol 4:632-638.11102867
  • Zhong, X., Malhotra, R., Guidotti, G. (2003). "ATP uptake in the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase." J Biol Chem 278:33436-33444.12807869
  • Zhu, Y., Vionnet, C., Conzelmann, A. (2006). "Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi." J Biol Chem 281:19830-19839.16704983