Identification
NamePalmitoyltransferase PFA4
Synonyms
  • Protein fatty acyltransferase 4
Gene NamePFA4
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein-cysteine S-palmitoleyltransferase a
Specific FunctionCan palmitoylate RAS2 in vitro
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
Palmityl-CoA + P29465 ↔ P29465
Metabolites
YMDB IDNameView
GO Classification
Function
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
zinc ion binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1137 bp ATGCCAGTAAAGTTAAGGTGGCCTTGGTTAGGAATTGCTATACCAACGTTTCTGATTTCA TTTATAGGCTATGGTGCACACTACTTTATTTTATCCAATTTCTTGTCAGTTCCGAAACAA ATAACATTTGAGTTCTGTTTGTCAATGATATGGCTCTCCTATTACTTGGCCATCTGCACA AATCCAGGAAGGCCTTTGCCCAACTACAAACCACCCCCTGATATCTGGCGGAATTTCTGT AAGAAGTGCCAAAGTTATAAGCCAGAACGTTCACATCATTGTAAAACCTGCAATCAATGC GTCCTAATGATGGATCATCATTGTCCGTGGACGATGAATTGCGTCGGCTTTGCAAACTAT CCGCATTTCCTTAGATTCTTATTTTGGATCATAGTGACGACTAGTGTTTTATTTTGCATA CAAGCTAAGCGGATATATTTTATTTGGCAACAAAGGCACTTGCCTGGCTACTTCTTCAAA AAATCAGAACTGATTTTCTTAACAATATCGAGTCCTTTAAATTCTTTTGTCCTACTAACG ATAACAATTCTTTTCCTACGATGTTTATTCAATCAAATCTTGAATGGAAGATCTCAAATT GAGTCGTGGGATATGGATCGGCTAGAATCTTTGTTCAACTCCGGAAGATTAACTCAGAAA TTAATTGATAATACTTGGAGAATATATCCAGAGTCGAGGTCGTTTCAAAATAAAAAGGAT GCTGAGGAACACTTGACAAAAAAAAGGCCACGTTTTGATGAACTTGTAAATTTCCCTTAC GATTTTGATTTGTACACTAATGCATTACTGTACCTTGGTCCCATTCATTTATGGTTATGG CCATATGGTGTTCCTACGGGAGATGGGAACAATTTTCCAAAAAACGGTATTTCAAAATAT GAGGCTAACTCCTCATTGGAAGACCACATCCTTTCACTTCCCTGGCCACCAGATGGAGGT AAAACAAACACCGTCTTCAATCATGGCAGCTCAACAATAGAGATGCGTAATGAAAGTGGC GAACAGCTAATAAGGACCAGACTTCCTCAAAATGGCAGACATGCTTCTCGTGAGAAGTGG TACAACGACTGGGGTGAATCACTAGACGATTTTGGAGTGGATGTTGATATGGAATAG
Protein Properties
Pfam Domain Function
Protein Residues378
Protein Molecular Weight44487.80078
Protein Theoretical pI8.34
Signalling Regions
  • None
Transmembrane Regions
  • 10-30
  • 41-61
  • 120-140
  • 165-185
Protein Sequence>Palmitoyltransferase PFA4 MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICT NPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANY PHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLT ITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKD AEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKY EANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKW YNDWGESLDDFGVDVDME
References
External Links
ResourceLink
Saccharomyces Genome Database PFA4
Uniprot IDQ12006
Uniprot NamePFA4_YEAST
GenBank Gene IDAY558023
Genebank Protein ID45269936
General Reference
  • Sterky, F., Holmberg, A., Pettersson, B., Uhlen, M. (1996). "The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes." Yeast 12:1091-1095.8896276
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Zhao, L., Lobo, S., Dong, X., Ault, A. D., Deschenes, R. J. (2002). "Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins." J Biol Chem 277:49352-49359.12379641
  • Valdez-Taubas, J., Pelham, H. (2005). "Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation." EMBO J 24:2524-2532.15973437
  • Smotrys, J. E., Schoenfish, M. J., Stutz, M. A., Linder, M. E. (2005). "The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p." J Cell Biol 170:1091-1099.16186255
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258