Palmitoyltransferase SWF1 (Q04629)

Identification
NamePalmitoyltransferase SWF1
Synonyms
  • Spore wall formation protein 1
Gene NameSWF1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein-cysteine S-palmitoleyltransferase a
Specific FunctionPalmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
P31377 + Palmityl-CoA ↔ P31377
Palmityl-CoA + P31109 ↔ P31109
Palmityl-CoA + Q03322 ↔ Q03322
Metabolites
YMDB IDNameView
GO Classification
Function
metal ion binding
transition metal ion binding
zinc ion binding
binding
ion binding
cation binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1011 bp ATGTCATGGAATCTACTATTTGTGCTGCTAATAGGATTCGTAGTTTTGATATTACTTTCG CCCGTCTTCAAGTCAACATGGCCATTTTCGACTTTCTATCGTAATGTGTTTCAGCCCTTC CTAGTGGATGACCAAAAATATCGTTGGAAGTTGCATTTAGTACCTCTTTTCTACACCTCT ATTTACCTGTACCTAGTATATACATACCACATGAGAGTGGAGTCTACGATTAAGAATGAG CTATTCCTTTTAGAACGAATACTGATCGTGCCTATAATTATACTACCGCCGGTAGCATTA GGAATTCTAGCCATGGTAAGCAGAGCTGAGGATTCAAAGGATCATAAATCAGGCTCGACA GAGGAATATCCATATGATTACCTATTGTATTATCCTGCCATAAAGTGTTCGACATGCCGG ATCGTCAAGCCTGCTAGATCCAAACATTGTAGCATTTGCAACCGATGCGTTCTCGTCGCC GACCATCATTGCATCTGGATAAATAACTGCATCGGAAAGGGAAACTACCTTCAATTCTAC CTTTTCCTAATTTCCAACATATTCTCGATGTGCTACGCCTTTCTAAGGCTGTGGTACATT TCTTTAAATAGCACAAGTACGCTCCCTAGAGCTGTTCTGACTCTTACCATATTATGTGGA TGCTTCACTATCATCTGCGCTATTTTCACGTATCTTCAATTGGCCATTGTAAAGGAGGGA ATGACTACAAATGAGCAAGATAAATGGTATACCATTCAAGAGTATATGAGAGAAGGAAAA CTGGTGAGATCATTGGATGATGATTGCCCATCTTGGTTTTTCAAATGCACAGAACAAAAA GATGACGCTGCTGAACCACTCCAAGATCAACATGTTACGTTTTATAGCACGAATGCCTAC GACCATAAGCACTACAACCTTACACACTACATCACGATTAAAGACGCGTCCGAAATTCCC AATATATATGACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAG
Protein Properties
Pfam Domain Function
Protein Residues336
Protein Molecular Weight39311.39844
Protein Theoretical pI7.41
Signalling Regions
  • None
Transmembrane Regions
  • 3-23
  • 51-71
  • 87-107
  • 180-200
  • 217-237
Protein Sequence>Palmitoyltransferase SWF1 MSWNLLFVLLIGFVVLILLSPVFKSTWPFSTFYRNVFQPFLVDDQKYRWKLHLVPLFYTS IYLYLVYTYHMRVESTIKNELFLLERILIVPIIILPPVALGILAMVSRAEDSKDHKSGST EEYPYDYLLYYPAIKCSTCRIVKPARSKHCSICNRCVLVADHHCIWINNCIGKGNYLQFY LFLISNIFSMCYAFLRLWYISLNSTSTLPRAVLTLTILCGCFTIICAIFTYLQLAIVKEG MTTNEQDKWYTIQEYMREGKLVRSLDDDCPSWFFKCTEQKDDAAEPLQDQHVTFYSTNAY DHKHYNLTHYITIKDASEIPNIYDKGTFLANLTDLI
References
External Links
ResourceLink
Saccharomyces Genome Database SWF1
Uniprot IDQ04629
Uniprot NameSWF1_YEAST
GenBank Gene IDAY557692
Genebank Protein ID45269277
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Valdez-Taubas, J., Pelham, H. (2005). "Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation." EMBO J 24:2524-2532.15973437
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258