Dolichyl-phosphate-mannose--protein mannosyltransferase 5 (P52867)

Identification
NameDolichyl-phosphate-mannose--protein mannosyltransferase 5
SynonymsNot Available
Gene NamePMT5
Enzyme Class
Biological Properties
General FunctionInvolved in mannosyltransferase activity
Specific FunctionTransfers mannose from Dol-P-mannose to Ser or Thr residues on proteins
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG Pathways
O-Mannosyl glycan biosynthesisec00514 Map00514
SMPDB ReactionsNot Available
KEGG Reactions
dolichyl D-mannosyl phosphate → dolichyl phosphate + hydron + mannan
Metabolites
YMDB IDNameView
YMDB00937dolichyl D-mannosyl phosphateShow
GO Classification
Component
cell part
membrane
Function
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
mannosyltransferase activity
catalytic activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
protein amino acid O-linked glycosylation
Gene Properties
Chromosome Locationchromosome 4
LocusYDL093W
Gene Sequence>2232 bp ATGAATAAAGAGCATTTGCTGAAGGTGGATCCCATCCCCGATGTGACTATTAAACGCGGC CCTTTGAGGTCTTTTCTCATAACAAAACCCTGTGATAATTTGAGTTCATTACGAACAGTT ACTTCATCTAAGGAAAAGCTTCTAGTTGGCTGTTTGCTGATATTTACTGCCATCGTAAGG CTACACAATATCTCCCTGCCAAATAGTGTTGTTTTTGGTGAAAATGAAGTTGGTACATTT GTTTCTCAATACGTGAACAACATATTCTTCACCGATGTTCATCCTCCTTTAGTGGCAATG CTATATGCAACCGTGTCCTCTGTTTTTGGTTATAAAGGGCTTTTCAATTATGGGAACATT GGTACTGAATACACGGCAAACGTTCCATACGTCGCGATGAGGTTCTTTTCTGCTACTTTG GGCATCGTGTCCGTTTTGGTATTATACTTAACGTTACGAGTTTCTGGCGTGAAAATTGCG GTAGCTGCCATTTGTGCAGTATGTTTTGCAATTGAAAACTCCTTTGTAACGTTGTCTCGT TTCACCTTGATAGAGGGACCCTTTGTTTTTTTCATGGCATGTGCAGTTTATTTCTTTAGA AGATCGGAACTTTATTTGCCAAATTCATGTAAAGCAAACAAGTCATTACTTGCTGCGAGC ATTGCATTGGGATTTGCAGTTTCTTCAAAATGGGCTGGCCTCTTCACCATCGCATGGGCT GGTATTATTGTCCTTTGGAGAGTATGGTTCATGATTGGTGATTTGTCAAGACCCATTGGT TCTTCTATCAAATATATGGCGTTCCAGTTTACCTGTCTATTAGCTATTCCTGCCTTCATC TATTTTCTCATTTTCAGCGTGCATATTAAGACATTAAACGTGAATGGTATTAGTAGTAGC TTTTTTCCCGCTGAGTTTAGAAAAACTTTAAAATACAACAACGTTATTAAAGAGACTGTG GCAGAAGTTGCAGTGGGTTCCGCTGTTTCACTGAATCATGTTGGAACGGCAGGTGGTTAC TTGCATTCTCATCTTCACAATTATCCGGCTGGTTCCATGCAACAACAAGTTACTTTGTAT CCTCACATCGACCAAAATAACAAATGGATTATTGAGCTGGCTGAACATCCAAATGAAAAT GTCACAAGTTTCCAAAATTTAACCGACGGTACCATAATTAAATTAAGACAGCTTAAGAAC GGCTGCAGGTTACACTCACATGACCACAAACCTCCAGTTTCTCAAAATGCGGATTGGCAA AAAGAGGTGTCATGTTATGGATACGAGGGCTTCGAAGGTGATATAAATGATGATTGGATA ATTGAAATCGATAAAAAGAGATCAGAGCCGGGACCTGCCCAGGAACATATTAGGGCTATT GAAACCAAATTTAGGCTGAAGCATTATCTAACTGGTTGTTACTTATTTTCACATCCTGAA AAGCTACCTGAGTGGGGATTCGGGCAGCAGGAAGTTACGTGTGCATACTTTGCAAGGGAA GACTTAACTTCATGGTATATTGAAGAAAACGAAAACGAAATTTCTTTGCCAAATCCAGAG AAGGTTTCTTATAAGAAAATGAGCTTTTGGCAGAAGTTTGTTGCTATCCACAAGTTCATG TTCTACCTTAACAATTATATGGATACTAGTCATGCCTACTCATCTGAACCAAAGACTTGG CCTCTTATGTTGCGTGGTATTGATTTTTGGAATGAAAATGGCAGAGAGGTGTACTTTTTA GGTAACGCTGTTTTGTGGTGGTCTGTCACAGCATTTATTTGCACGTTCATCATTGGAGTG GCTGTTGAGCTTCTTGCTTGGAAATTAGGTGTGAATATTCTACGGGATAAGCACATCATA AATTTCCACTATCAGGTCTTTCAGTACTTATTAGGCTTTGCCGCCCACTATTTCCCTTAC TTCTTTGTGGGGCAAAAGTTATTTTTGTACGATTATTTGCCGGCCTATTATTTTGGTATC CTAGCATTTGGTCATGCTTTAGACCTGATTTCAACCTATATTTCTAACAAAAGAAACAAT ACTGGATATATAGTGGTGGCTATTTTCATGGTTGTATGTTTCTATTTCTTCAGCGAGCAT TCTCCACTTATTTATGCTACTGGATGGTCGAGTAACCTGTGTAAGAGGTCCAAGTGGTTA GGAAGCTGGGACTTTTATTGCAATTCACTATTACTATCCGATAGCCACTATGAATTAAAC GCTGAATCATGA
Protein Properties
Pfam Domain Function
Protein Residues743
Protein Molecular Weight84775.20313
Protein Theoretical pI7.95
Signalling Regions
  • None
Transmembrane Regions
  • 47-67
  • 130-150
  • 159-179
  • 181-201
  • 232-252
  • 265-285
  • 584-604
  • 624-644
  • 647-667
  • 684-704
Protein Sequence>Dolichyl-phosphate-mannose--protein mannosyltransferase 5 MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVR LHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNI GTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSR FTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWA GIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSS FFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLY PHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQ KEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPE KLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFM FYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGV AVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGI LAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWL GSWDFYCNSLLLSDSHYELNAES
References
External Links
ResourceLink
Saccharomyces Genome Database PMT5
Uniprot IDP52867
Uniprot NamePMT5_YEAST
GenBank Gene IDX92759
Genebank Protein ID1483592
General Reference
  • Boskovic, J., Soler-Mira, A., Garcia-Cantalejo, J. M., Ballesta, J. P., Jimenez, A., Remacha, M. (1996). "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames." Yeast 12:1377-1384.8923743
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258