Dolichyl-phosphate-mannose--protein mannosyltransferase 3 (P47190)

Identification
NameDolichyl-phosphate-mannose--protein mannosyltransferase 3
SynonymsNot Available
Gene NamePMT3
Enzyme Class
Biological Properties
General FunctionInvolved in mannosyltransferase activity
Specific FunctionTransfers mannose from Dol-P-mannose to Ser or Thr residues on proteins
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG Pathways
O-Mannosyl glycan biosynthesisec00514 Map00514
SMPDB ReactionsNot Available
KEGG Reactions
dolichyl D-mannosyl phosphate → dolichyl phosphate + hydron + mannan
Metabolites
YMDB IDNameView
YMDB00937dolichyl D-mannosyl phosphateShow
GO Classification
Component
cell part
membrane
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
mannosyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
protein amino acid O-linked glycosylation
Gene Properties
Chromosome Locationchromosome 15
LocusYOR321W
Gene Sequence>2262 bp ATGCCGTACAGAGTGGCGACGGGCTACAGTGAAAAAAGTACTGACGATGATTTGATATGG AGAACGCCAATAGTAAAAGAGGAACTCGAGGATGCTGACAACTTTTTAAAGGATGATGCC GAGTTGTATGATAAAGTCAAGAACGAGAGTGCAGTATCACACCTGGATACCATAGTTATG CCGATCATTTTCACGGTACTGGGCATGTTCACTAGAATGTACAAGATTGGTCGTAATAAT CATGTGGTCTGGGATGAAGCTCATTTTGGTAAGTTCGGCTCTTACTATCTGAGACACGAA TTTTACCATGATGTTCATCCACCTTTAGGTAAAATGCTTGTTGGACTGTCTGGTTATTTG GCTGGCTACAATGGTTCTTGGGACTTCCCATCTGGTGAGGTTTATCCCGACTATATCGAT TATGTGAAAATGAGGTTATTTCAAGCAATGTTTTCATCATTGTGTGTGCCACTAGCCTAT TTCACAGGAAGGGCTATCGGATTTTCTAGGCTGAGTGTTTGGCTATTTACCATTCTAGTA ATTTTTGAGAATTCGTATGCAACATTAGGCAAGTTCATTCTCCTTGATTCAATGCTACTT TTCTTTACCGTCTCTTCTTACTTTTGCCTTGCCAAGTTCCATACTATGAGAAAGTCTCCC TTTTCGGCTAGGTGGTGGCTATGGTTGTGCCTCACTGGGTTGAATTTGGGTTGCGCTATA TCTGTGAAAATGGTAGGTCTTTTCATCATCAGTGTAGTAGGAATTTACACCATCAGTGAA CTATGGAATCTCCTAAGTGATAGATCGGTGTCTTGGAAGGTTTATGTCAACCATTGGCTA GCAAGAATATTCGGGCTTATCATCATTCCTGTTTGCGTTTTTTTGTTATGCTTCAAAATC CATTTTGATCTGCTGTCCAACTCAGGGCCCGGCGACTCTACCATGCCATCATTATTTCAA GCCAGTCTGAACGGTACAAAAGTTGGTAAGGGACCACGTGATGTTGCTTTGGGTTCTTCT ATTATTTCCATCAAAAATCAAGCGTTGGGAGGCGCTTTATTACATTCTCATGTCCAACCA TTCCCAGAAGGTTCTGAGCAACAGCAAGTAACTGTCTATGGTTACAGTGATGCTAACAAT GAATGGTTTTTTCAAAGAATCAGAGGAGTAGAGCCTTGGACTGATGCGCACAACAAGACA ATTGAGTTTGTAAAGGGTGGCGAAATGTATAGATTAATGCATCGCCTAACAGGCAAGAAT CTACACACCCATGAAGTCCCAGCGCCTATATCGAAAAGTGAATATGAAGTTTCTGCTTAC GGAGATGTAGACTTAGGTGACTACAAAGATAACTGGATTATAGAAATCGTGGAACAAGTA GGGGAAGAAGATCCAACACTACTACACCCGCTATCCACATCTTTCCGTATTAAAAATTCT ATACTGGGTTGCTATTTAGCTCAGTCAGGTAAACATTTACCAGAATGGGGTTTCAGGCAA GGTGAAGTTGTCTGTTTAAAACACGCCTCCAAAAGGGATAAGAGAACCTGGTGGAATATC GAAACACATGAAAATGAAAGATTGCCACAGGGAGAAGATTTCGTATATCCGAAGACTTCA TTCTTCAGGAATTTCATGCAGTTAAATTCAGCAATGATGGCAACCAATAATGCTTTGGTA CCAAACCCTGAAAAGTTTAATGGTATAGCTTCATCTGCCTGGCAATGGCCAACCTTGAAC GTCGGGGTAAGATTATGCGAATGGAGTGAAAAATCTATAAAGTACTTCTTATTAGGATCT CCTGCGTCCGTCTGGCCCTCAAGCATCGCAGTTTGCGCACTGATAATACACGTTATATTC TTAACTCTGAAATGGCAGAGACAATGTGTTATCCTATCCGATCCAGTCGAACGTGACGTG TTCGTTATGGCAGCCTTTTATCCATTGCTTGCTTGGCTTTTACATTATATGCCATTCGTA GTGATGTCAAGAGTTGTATACGCTCACCACTATCTGCCCACCCTTTATTTTGCCTTAATG ATCTTGTCATACTACTTCGATATGATTACCAAACGTTGGGCTACAAGAAACACTGGAAAA TTTCTAAGGCTAGGAGCTTATATTGTATACGGATCAATCGTGATCGCTGGATTTTTTTAT TTCTCTCCTTTTAGTTTTGGGATGGATGGTCCAGTAGATGATTACGCGTACTTGGCATGG CTACCTACGTGGCAGATTGTTGAAGATATACGTAACACATAG
Protein Properties
Pfam Domain Function
Protein Residues753
Protein Molecular Weight86322.0
Protein Theoretical pI6.9
Signalling Regions
  • None
Transmembrane Regions
  • 51-71
  • 149-169
  • 175-195
  • 236-256
  • 283-303
  • 603-623
  • 640-660
  • 666-686
  • 704-724
Protein Sequence>Dolichyl-phosphate-mannose--protein mannosyltransferase 3 MPYRVATGYSEKSTDDDLIWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVM PIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYL AGYNGSWDFPSGEVYPDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILV IFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSARWWLWLCLTGLNLGCAI SVKMVGLFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKI HFDLLSNSGPGDSTMPSLFQASLNGTKVGKGPRDVALGSSIISIKNQALGGALLHSHVQP FPEGSEQQQVTVYGYSDANNEWFFQRIRGVEPWTDAENKTIEFVKGGEMYRLMHRLTGKN LHTHEVPAPISKSEYEVSAYGDVDLGDYKDNWIIEIVEQVGEEDPTLLHPLSTSFRIKNS ILGCYLAQSGKHLPEWGFRQGEVVCLKHASKRDKRTWWNIETHENERLPQGEDFVYPKTS FFRNFMQLNSAMMATNNALVPNPEKFDGIASSAWQWPTLNVGVRLCEWSEKSIKYFLLGS PASVWPSSIAVCALIIHVIFLTLKWQRQCVILSDPVERDVFVMAAFYPLLAWLLHYMPFV VMSRVVYAHHYLPTLYFALMILSYYFDMITKRWATRNTGKFLRLGAYIVYGSIVIAGFFY FSPFSFGMDGPVDDYAYLAWLPTWQIVEDIRNT
References
External Links
ResourceLink
Saccharomyces Genome Database PMT3
Uniprot IDP47190
Uniprot NamePMT3_YEAST
GenBank Gene IDX83797
Genebank Protein ID633652
General Reference
  • Immervoll, T., Gentzsch, M., Tanner, W. (1995). "PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae." Yeast 11:1345-1351.8585318
  • Pearson, B. M., Hernando, Y., Payne, J., Wolf, S. S., Kalogeropoulos, A., Schweizer, M. (1996). "Sequencing of a 35.71 kb DNA segment on the right arm of yeast chromosome XV reveals regions of similarity to chromosomes I and XIII." Yeast 12:1021-1031.8896266
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258