Palmitoyltransferase PFA3 (P42836)

Identification
NamePalmitoyltransferase PFA3
Synonyms
  • Protein fatty acyltransferase 3
Gene NamePFA3
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein-cysteine S-palmitoleyltransferase a
Specific FunctionPalmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization
Cellular LocationVacuole membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
Palmityl-CoA + P39968 ↔ P39968
Metabolites
YMDB IDNameView
GO Classification
Function
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
zinc ion binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1011 bp ATGAATGACAGGCTTTCGTTGACAAGTCTGTTTCCCAGGTGTTTGACCACATGTTTGTAT ATTTGGACTGCATACATAACATTGACAAGGATTCATCAAATACCTAGGTGGTTTCTCGCG CTAACAATAGTTCCGACATTGGCAGTGGCTCTATACACTTATTATAAGGTTATTGCTAGA GGTCCCGGTTCTCCTCTAGATTTCCCTGATTTGTTAGTCCACGATTTAAAGGCAGCGGAA AATGGACTTGAACTTCCTCCGGAGTATATGTCAAAAAGGTGTTTGACCTTAAAACATGAT GGAAGATTTCGGGTGTGCCAAGTATGCCATGTTTGGAAGCCCGATCGCTGTCATCATTGT TCATCATGCGATGTTTGCATATTGAAAATGGATCATCATTGCCCTTGGTTCGCTGAATGC ACTGGTTTTAGGAATCAAAAATTTTTTATTCAATTCTTAATGTACACAACATTATACGCG TTCTTAGTCCTAATTTATACTTGCTATGAGCTTGGGACGTGGTTTAACTCCGGTAGTTTC AACCGTGAATTGATAGATTTTCATCTATTAGGGGTGGCCCTATTGGCGGTTGCTGTTTTC ATTTCTGTTTTAGCATTTACCTGTTTCAGCATTTATCAGGTTTGTAAAAACCAAACTACT ATCGAGGTACACGGAATGAGAAGGTATCGAAGGGATCTTGAAATCCTCAATGACAGCTAT GGAACAAATGAGCATTTAGAGAATATATTTGACTTGGGTTCTTCAATGGCCAACTGGCAA GATATAATGGGTACATCTTGGTTAGAGTGGATACTTCCTATTGAGACCTTCAAGTACAAA AAGTCTAAACACACAAAGGATGAAAAAGGTTTATATTTTAATGTAAGACCTCAAGTACAA GACCGACTGCTAAGTAGTAGATGTTTAGAAGATCAATTACTGAGAAGAGTAACACCAAGA CCCTCATTAGAAGCCGATAGGGCGTCTGTAGAAATTATCGATGCAAATTAG
Protein Properties
Pfam Domain Function
Protein Residues336
Protein Molecular Weight39183.10156
Protein Theoretical pI7.78
Signalling Regions
  • None
Transmembrane Regions
  • 7-29
  • 38-58
  • 148-168
  • 189-209
Protein Sequence>Palmitoyltransferase PFA3 MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIVPTLAVALYTYYKVIAR GPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGRFRVCQVCHVWKPDRCHHC SSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYAFLVLIYTCYELGTWFNSGSF NRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQTTIEVHGMRRYRRDLEILNDSY GTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIETFKYKKSKHTKDEKGLYFNVRPQVQ DRLLSSRCLEDQLLRRVTPRPSLEADRASVEIIDAN
References
External Links
ResourceLink
Saccharomyces Genome Database PFA3
Uniprot IDP42836
Uniprot NamePFA3_YEAST
GenBank Gene IDZ46259
Genebank Protein ID633660
General Reference
  • Maftahi, M., Nicaud, J. M., Levesque, H., Gaillardin, C. (1995). "Sequencing analysis of a 15.4 kb fragment of yeast chromosome XIV identifies the RPD3, PAS8 and KRE1 loci, five new open reading frames." Yeast 11:567-572.7645347
  • Philippsen, P., Kleine, K., Pohlmann, R., Dusterhoft, A., Hamberg, K., Hegemann, J. H., Obermaier, B., Urrestarazu, L. A., Aert, R., Albermann, K., Altmann, R., Andre, B., Baladron, V., Ballesta, J. P., Becam, A. M., Beinhauer, J., Boskovic, J., Buitrago, M. J., Bussereau, F., Coster, F., Crouzet, M., D'Angelo, M., Dal Pero, F., De Antoni, A., Del Rey, F., Doignon, F., Domdey, H., Dubois, E., Fiedler, T., Fleig, U., Floeth, M., Fritz, C., Gaillardin, C., Garcia-Cantalejo, J. M., Glansdorff, N. N., Goffeau, A., Gueldener, U., Herbert, C., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hinni, K., Iraqui Houssaini, I., Jacquet, M., Jimenez, A., Jonniaux, J. L., Karpfinger, L., Lanfranchi, G., Lepingle, A., Levesque, H., Lyck, R., Maftahi, M., Mallet, L., Maurer, K. C., Messenguy, F., Mewes, H. W., Mosti, D., Nasr, F., Nicaud, J. M., Niedenthal, R. K., Pandolfo, D., Pierard, A., Piravandi, E., Planta, R. J., Pohl, T. M., Purnelle, B., Rebischung, C., Remacha, M., Revuelta, J. L., Rinke, M., Saiz, J. E., Sartorello, F., Scherens, B., Sen-Gupta, M., Soler-Mira, A., Urbanus, J. H., Valle, G., Van Dyck, L., Verhasselt, P., Vierendeels, F., Vissers, S., Voet, M., Volckaert, G., Wach, A., Wambutt, R., Wedler, H., Zollner, A., Hani, J. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature 387:93-98.9169873
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Smotrys, J. E., Schoenfish, M. J., Stutz, M. A., Linder, M. E. (2005). "The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p." J Cell Biol 170:1091-1099.16186255
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258