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Identification
NameS-formylglutathione hydrolase
Synonyms
  • FGH
Gene NameNot Available
Enzyme Class
Biological Properties
General FunctionInvolved in carboxylesterase activity
Specific FunctionSerine hydrolase involved in the detoxification of formaldehyde
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG Pathways
Methane metabolismec00680 Map00680
SMPDB ReactionsNot Available
KEGG Reactions
S-Formylglutathione + waterGlutathione + Formic acid + hydron
Metabolites
YMDB IDNameView
YMDB00056Acetic acidShow
YMDB00160GlutathioneShow
YMDB00320S-FormylglutathioneShow
YMDB00385Formic acidShow
YMDB00862hydronShow
YMDB00890waterShow
YMDB009714-methylumbelliferoneShow
GO Classification
Component
organelle
vesicle
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
Function
hydrolase activity, acting on ester bonds
carboxylesterase activity
thiolester hydrolase activity
S-formylglutathione hydrolase activity
catalytic activity
hydrolase activity
Process
Not Available
Gene Properties
Chromosome LocationNot Available
LocusYJL068C
Gene Sequence>859 bp GATCAAGTTGTCACATAACTCGAACTCTACCAAGACCAGCATGAACGTCAATATCTATTT GCCTAAGCACTATTACGCCCAAGATTTTCCAAGAAATAAGCGTATCCCAACTGTGTTTTA CCTTTCTGGCTTGACGTGCACGCCAGACAACGCCTCTGAGAAGGCTTTTTGGCAGTTTCA AGCTGACAAGTACGGATTTGCAATAGTCTTTCCGGATACGTCCCCACGTGGTGACGAAGT AGCCAATGATCCTGAGGGCTCCTGGGATTTTGGACAGGGCGCCGGATTCTATCTAAATGC CACCCAAGAACCATACGCCCAACATTACCAGATGTACGACTACATTCACAAAGAACTCCC ACAAACATTAGATTCTCATTTTAACAAGAACGGTGACGTAAAGCTGGACTTCTTGGACAA TGTTGCCATCACAGGCCATTCGATGGGGGGATATGGTGCAATTTGTGGGTATTTGAAGGG CTATTCCGGAAAGAGATACAAATCTTGTTCTGCCTTCGCCCCTATCGTGAACCCTTCCAA CGTTCCCTGGGGTCAAAAAGCGTTTAAAGGTTATCTGGGCGAAGAAAAAGCCCAGTGGGA AGCGTACGACCCATGTTTATTAATCAAGAATATTAGACATGTGGGCGACGACAGAATTTT GATCCATGTAGGAGACTCCGATCCCTTTTTGGAAGAACACTTGAAACCGGAATTACTACT TGAGGCGGTGAAAGCCACTTCATGGCAGGACTACGTGGAAATAAAAAAAGTTCACGGCTT TGATCACTCCTATTACTTTGTCAGCACTTTCGTTCCAGAACATGCTGAATTTCATGCGCG AAACTTGGGTTTGATTTGA
Protein Properties
Pfam Domain Function
Protein Residues299
Protein Molecular Weight33934.0
Protein Theoretical pI6.7
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>S-formylglutathione hydrolase MKVVKEFSVCGGRLIKLSHNSNSTKTSMNVNIYLPKHYYAQDFPRNKRIPTVFYLSGLTC TPDNASEKAFWQFQADKYGFAIVFPDTSPRGDEVANDPEGSWDFGQGAGFYLNATQEPYA QHYQMYDYIHKELPQTLDSHFNKNGDVKLDFLDNVAITGHSMGGYGAICGYLKGYSGKRY KSCSAFAPIVNPSNVPWGQKAFKGYLGEEKAQWEAYDPCLLIKNIRHVGDDRILIHVGDS DPFLEEHLKPELLLEAVKATSWQDYVEIKKVHGFDHSYYFVSTFVPEHAEFHARNLGLI
References
External Links
ResourceLink
Saccharomyces Genome Database YJL068C
Uniprot IDP40363
Uniprot NameSFGH_YEAST
GenBank Gene IDX88851
Genebank Protein ID895893
PDB ID
1PV1
General Reference
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Degrassi, G., Uotila, L., Klima, R., Venturi, V. (1999). "Purification and properties of an esterase from the yeast Saccharomyces cerevisiae and identification of the encoding gene." Appl Environ Microbiol 65:3470-3472.10427036
  • Vandenbol, M., Durand, P., Dion, C., Portetelle, D., Hilger, F. (1995). "Sequence of a 17.1 kb DNA fragment from chromosome X of Saccharomyces cerevisiae includes the mitochondrial ribosomal protein L8." Yeast 11:57-60.7762302
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269