| Identification |
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| Name | Probable aconitate hydratase 2 |
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| Synonyms | - Aconitase
- Citrate hydro-lyase
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| Gene Name | ACO2 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in metabolic process |
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| Specific Function | Citrate = isocitrate |
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| Cellular Location | Not Available |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | | Citrate cycle (TCA cycle) | ec00020 |  | | Glyoxylate and dicarboxylate metabolism | ec00630 |  |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00026 | Isocitric acid | Show | | YMDB00086 | Citric acid | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| hydro-lyase activity | | 4 iron, 4 sulfur cluster binding | | aconitate hydratase activity | | catalytic activity | | lyase activity | | binding | | metal cluster binding | | iron-sulfur cluster binding | | carbon-oxygen lyase activity | | Process |
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| acetyl-CoA metabolic process | | acetyl-CoA catabolic process | | tricarboxylic acid cycle | | metabolic process | | cellular metabolic process | | cofactor metabolic process | | coenzyme metabolic process |
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| Gene Properties |
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| Chromosome Location | chromosome 10 |
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| Locus | YJL200C |
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| Gene Sequence | >2370 bp
ATGCTATCTTCAGCTAATAGGTTTTATATAAAGAGGCATTTGGCAACACATGCCAATATG
TTCCCCTCTGTATCTAAAAATTTTCAAACAAAAGTGCCACCTTATGCAAAACTTTTGACC
AACCTAGACAAGATTAAACAAATAACAAACAATGCTCCATTGACACTAGCAGAAAAAATT
TTATACTCGCATCTTTGCGATCCTGAAGAATCGATTACTTCTTCTGATCTGTCCACCATC
CGTGGTAATAAATACTTGAAGCTAAACCCAGACCGTGTAGCTATGCAGGACGCTTCTGCC
CAAATGGCGCTTCTACAATTCATGACCACCGGTCTAAATCAAACATCTGTCCCAGCATCC
ATACATTGTGATCATTTAATTGTAGGTAAGGACGGTGAAACTAAAGATTTACCCTCTTCC
ATAGCTACCAACCAAGAAGTTTTCGATTTCTTGGAGAGTTGCGCAAAGAGATATGGAATT
CAATTCTGGGGCCCAGGTTCTGGTATCATTCACCAGATTGTTTTGGAAAATTTCTCAGCT
CCAGGTCTAATGATGCTAGGTACTGATTCCCATACACCAAATGCAGGCGGTCTGGGAGCT
ATTGCCATCGGGGTTGGTGGTGCGGATGCAGTTGATGCCCTCACAGGCACTCCATGGGAA
TTAAAAGCACCAAAAATTTTAGGTGTTAAATTGACCGGAAAGTTAAACGGATGGTCCACT
CCTAAAGATGTAATCACAAAGCTCGCTGGTTTACTAACTGTCAGAGGTGGTACTGGTTAT
ATCGTCGAGTACTTCGGCGAAGGTGTATCCACTCTATCTTGCACAGGTATGGCAACCATC
TGTAATATGGGAGCTGAAATCGGTGCTACAACGTCAACTTTCCCTTACCAAGAAGCTCAC
AAGCGTTATTTGCAAGCAACTAATAGAGCAGAGGTCGCTGAAGCAGCTGATGTTGCTTTA
AACAAGTTTAACTTCTTAAGAGCCGACAAAGATGCTCAATACGATAAAGTTATTGAAATT
GACTTATCCGCAATTGAACCTCACGTTAATGGTCCATTTACACCAGACCTTTCAACCCCA
ATATCTCAATATGCCGAAAAAAGTTTGAAGGAAAACTGGCCCCAAAAAGTTAGCGCTGGT
TTGATTGGATCATGTACCAATTCATCTTATCAAGACATGAGTCGTGTTGTCGACTTGGTC
AAGCAAGCTTCCAAAGCCGGCTTGAAACCACGTATCCCCTTCTTTGTCACCCCTGGTTCA
GAACAAATTAGAGCTACCTTGGAAAGAGATGGAATCATCGATATTTTCCAAGAAAATGGT
GCCAAAGTTTTAGCAAATGCATGCGGCCCTTGTATCGGACAATGGAATAGGGAAGATGTC
TCGAAAACATCAAAAGAAACGAACACTATTTTTACATCATTCAATAGAAATTTCAGAGCT
AGAAACGATGGTAATAGGAATACAATGAATTTCTTAACATCCCCAGAAATAGTAACAGCG
ATGAGTTATTCTGGAGATGCTCAGTTCAATCCGCTAACTGACTCAATTAAATTGCCAAAT
GGGAAGGATTTCAAATTCCAACCACCAAAGGGTGATGAGTTACCAAAAAGAGGATTTGAA
CACGGTAGAGACAAATTTTATCCTGAAATGGATCCAAAGCCAGATAGCAATGTAGAGATT
AAGGTAGACCCTAATTCTGATCGTTTGCAATTATTAGAGCCATTCAAACCTTGGAACGGG
AAGGAATTGAAGACAAACGTGCTTTTGAAAGTTGAAGGTAAATGTACAACAGATCATATT
TCCGCTGCGGGCGTCTGGTTGAAATATAAAGGCCATCTAGAAAACATTTCTTACAATACA
TTGATTGGTGCACAAAACAAAGAAACCGGTGAAGTCAACAAGGCTTATGACCTTGACGGA
ACTGAATATGATATTCCTGGTTTGATGATGAAATGGAAATCAGACGGTAGACCATGGACC
GTGATAGCGGAACATAACTATGGTGAAGGTTCCGCAAGAGAGCATGCTGCTTTGTCACCA
AGATTTTTAGGCGGAGAGATTCTTTTAGTTAAGTCTTTTGCAAGAATTCATGAGACAAAC
TTGAAGAAACAAGGTGTGTTGCCATTGACTTTTGCCAACGAATCTGACTATGATAAAATA
TCAAGCGGAGATGTTTTAGAAACGTTGAACCTAGTTGACATGATTGCTAAGGATGGTAAT
AACGGTGGTGAAATTGATGTTAAAATTACTAAACCAAACGGTGAATCGTTCACCATCAAG
GCAAAACATACTATGTCTAAAGATCAAATCGATTTTTTCAAAGCTGGTTCAGCAATCAAT
TATATTGGTAATATACGAAGAAACGAATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 789 |
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| Protein Molecular Weight | 86582.5 |
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| Protein Theoretical pI | 6.95 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Probable aconitate hydratase 2
MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKI
LYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPAS
IHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSA
PGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWST
PKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAH
KRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTP
ISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGS
EQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRA
RNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFE
HGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHI
SAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWT
VIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKI
SSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAIN
YIGNIRRNE |
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| References |
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| External Links | |
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| General Reference | - Purnelle, B., Coster, F., Goffeau, A. (1994). "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes." Yeast 10:1235-1249.7754713
- Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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