{"ymdb_id":"YMDB00086","created_at":"2011-05-29T15:55:22.000Z","updated_at":"2016-10-18T17:11:16.000Z","name":"Citric acid","cas":"77-92-9","state":"Solid","melting_point":"153 oC","description":"Citric acid is formed in the tricarboxylic acid cycle. Citric acid most commonly found in wine is commercially produced from fermenting sucrose solutions.","experimental_water_solubility":"592 mg/mL at 25 oC [YALKOWSKY,SH \u0026 HE,Y (2003)]","experimental_logp_hydrophobicity":"-1.64 [AVDEEF,A (1997)]","location":"Cytoplasm;Extracellular;Mitochondrion;Peroxisome","synthesis_reference":" Evans, D. W. S. Hydrolysis of ethyl methylenecitrate [5,5-bis(ethoxycarbonylmethyl)-1,3-dioxolan-4-one] and an attempted synthesis of agaric acid. Journal of the Chemical Society (1959), 1313-14.","chebi_id":"30769","hmdb_id":"HMDB00094","kegg_id":"C00158","pubchem_id":"311","cs_id":"305","foodb_id":null,"wikipedia_link":"Citric_acid","biocyc_id":"CIT","iupac":"2-hydroxypropane-1,2,3-tricarboxylic acid","traditional_iupac":"citric acid","logp":"-1.3226874519999998","pka":"4.674836176324","alogps_solubility":"1.06e+02 g/l","alogps_logp":"-1.33","alogps_logs":"-0.26","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"132.13","refractivity":"35.6239","polarizability":"15.53525731872116","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-4.185693450231931","pka_strongest_acidic":"3.0479515131680732","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Hydroxy-1,2,3-propanetricarboxylate","2-hydroxy-1,2,3-propanetricarboxylate(3-)","2-Hydroxy-1,2,3-propanetricarboxylic acid","2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-)","2-hydroxytricarballylate","3-Carboxy-3-hydroxypentane-1,5-dioate","3-Carboxy-3-hydroxypentane-1,5-dioic acid","Aciletten","Anhydrous citrate","Anhydrous citric acid","beta-Hydroxytricarballylate","beta-Hydroxytricarballylic acid","cit","cit(3-)","Citraclean","Citrate","CITRATE ANION","Citretten","Citric acid","Citro","Hydrocerol A","Kyselina citronova","Suby G","Uro-trainer"],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Glyoxylate cycle","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[{"growth_media":"Minimal medium  supplemented with ammonia salts","concentration":"2400.0","concentration_units":"\u0026#181;M","error":"100.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts and glucose","concentration":"13500.0","concentration_units":"\u0026#181;M","error":"9500.0"},{"growth_media":"Minimal medium supplemented with ammonia salts and (glucose or galactose)","concentration":"700.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"5200.0","concentration_units":"\u0026#181;M","error":"500.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"210.0","concentration_units":"\u0026#181;M","error":"10.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"1500.0","concentration_units":"\u0026#181;M","error":"400.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"3700.0","concentration_units":"\u0026#181;M","error":"700.0"},{"growth_media":"Synthetic medium ","concentration":"3100.0","concentration_units":"uM","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":15060153,"citation":"Lawrence, C. L., Botting, C. H., Antrobus, R., Coote, P. J. (2004). \"Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress.\" Mol Cell Biol 24:3307-3323."},{"pubmed_id":7961948,"citation":"Sandor, A., Johnson, J. H., Srere, P. A. (1994). \"Cooperation between enzyme and transporter in the inner mitochondrial membrane of yeast. Requirement for mitochondrial citrate synthase for citrate and malate transport in Saccharomyces cerevisiae.\" J Biol Chem 269:29609-29612."},{"pubmed_id":1897942,"citation":"Kispal, G., Srere, P. A. (1991). \"Studies on yeast peroxisomal citrate synthase.\" Arch Biochem Biophys 286:132-137."},{"pubmed_id":10587442,"citation":"Velot, C., Lebreton, S., Morgunov, I., Usher, K. C., Srere, P. A. (1999). \"Metabolic effects of mislocalized mitochondrial and peroxisomal citrate synthases in yeast Saccharomyces cerevisiae.\" Biochemistry 38:16195-16204."},{"pubmed_id":9140965,"citation":"Jia, Y. K., Becam, A. M., Herbert, C. J. (1997). \"The CIT3 gene of Saccharomyces cerevisiae encodes a second mitochondrial isoform of citrate synthase.\" Mol Microbiol 24:53-59."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T20:37:59.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Aconitate hydratase, mitochondrial","uniprot_id":"P19414","uniprot_name":"ACON_YEAST","enzyme":true,"transporter":false,"gene_name":"ACO1","num_residues":778,"molecular_weight":"85367.5","theoretical_pi":"8.24","general_function":"Involved in metabolic process","specific_function":"Required for growth on nonfermentable carbon sources and for biosynthesis of glutamate","reactions":[{"id":1391,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1412,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2332,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm.","altext":"Citrate = isocitrate.","export":false,"pw_reaction_id":null,"source":null},{"id":4168,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006466","source":"Smpdb"},{"id":4169,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006467","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm.","genbank_gene_id":"U17243","genbank_protein_id":"596052","gene_card_id":"ACO1","chromosome_location":"chromosome 12","locus":"YLR304C","synonyms":["Aconitase","Citrate hydro-lyase"],"enzyme_classes":["4.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" aconitate hydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glyoxylate cycle","kegg_map_id":null}],"gene_sequence":"ATGCTGTCTGCACGTTCTGCCATCAAGAGACCCATTGTTCGTGGTCTTGCGACAGTCTCCAACTTGACTAGAGATTCAAAAGTCAACCAAAACTTATTAGAAGATCATTCTTTTATTAACTACAAGCAGAATGTGGAAACGCTGGATATCGTAAGAAAAAGATTAAACAGGCCATTTACCTACGCGGAAAAGATTTTGTACGGTCACTTGGATGACCCTCATGGTCAAGATATTCAGAGAGGTGTTTCATACCTAAAATTAAGACCAGATCGTGTTGCCTGTCAAGATGCTACTGCTCAAATGGCTATTTTACAATTTATGTCCGCTGGTTTACCACAGGTTGCTAAGCCAGTCACTGTCCACTGTGACCATTTGATTCAAGCACAAGTTGGTGGTGAAAAAGATTTGAAGAGAGCTATAGATCTAAACAAGGAAGTTTATGATTTCTTGGCCTCTGCCACTGCGAAATATAACATGGGTTTCTGGAAGCCAGGTTCCGGTATCATTCACCAAATTGTTCTGGAAAACTACGCTTTCCCAGGTGCTTTGATCATTGGTACTGACTCCCATACACCAAATGCTGGTGGTTTAGGTCAATTGGCTATTGGTGTTGGTGGTGCTGATGCCGTTGATGTTATGGCAGGTCGTCCATGGGAATTGAAGGCTCCAAAGATCTTAGGTGTTAAGTTGACTGGTAAGATGAACGGTTGGACTTCTCCAAAGGATATTATTTTGAAATTGGCTGGTATCACAACTGTCAAAGGTGGTACTGGTAAAATTGTTGAATATTTCGGTGATGGTGTTGACACCTTCTCCGCTACTGGTATGGGTACCATTTGTAATATGGGTGCTGAAATCGGTGCTACCACATCTGTTTTCCCATTCAACAAATCTATGATTGAATATTTGGAAGCAACTGGTCGTGGTAAGATCGCTGACTTTGCTAAATTATACCACAAGGACCTATTATCTGCTGATAAGGATGCTGAATACGATGAGGTCGTCGAAATTGACTTGAACACTCTGGAACCATACATCAATGGGCCATTTACCCCCGATTTGGCTACTCCAGTTTCTAAGATGAAGGAAGTTGCTGTTGCTAATAACTGGCCATTGGATGTCAGAGTCGGTTTGATCGGTTCTTGTACCAATTCCTCTTATGAAGATATGTCTCGTTCAGCATCCATTGTCAAGGATGCTGCTGCTCATGGTTTGAAATCCAAGACCATTTTCACTGTTACTCCAGGTTCTGAACAAATCAGAGCCACTATTGAACGTGATGGCCAATTAGAAACCTTCAAAGAATTTGGTGGTATCGTTTTGGCAAACGCCTGTGGCCCATGTATTGGTCAATGGGATCGTAGAGATATCAAGAAAGGTGACAAGAATACTATCGTTTCCTCTTACAACAGAAATTTCACTTCTAGAAATGATGGTAACCCACAAACTCATGCTTTTGTTGCATCTCCAGAATTAGTAACTGCGTTCGCCATTGCGGGTGATTTGAGATTCAACCCTCTAACAGACAAATTAAAGGACAAGGATGGTAATGAGTTCATGTTGAAACCACCACATGGTGATGGTTTGCCTCAAAGAGGTTATGATGCTGGTGAGAACACTTACCAAGCTCCACCTGCAGACCGTAGCACCGTTGAAGTTAAAGTTTCTCCAACTTCAGACCGTCTACAACTGTTGAAACCATTCAAACCTTGGGATGGTAAGGATGCTAAAGACATGCCAATCTTGATTAAGGCCGTCGGTAAGACAACTACTGATCATATTTCTATGGCTGGTCCATGGTTGAAATACAGAGGTCATTTAGAAAACATTTCTAATAACTATATGATTGGTGCTATTAATGCTGAAAACAAGAAGGCTAACTGTGTTAAAAATGTATATACTGGTGAATACAAAGGTGTTCCAGACACTGCTAGAGATTACAGAGACCAAGGTATCAAGTGGGTTGTTATTGGTGATGAAAACTTTGGTGAAGGTTCCTCTCGTGAACACGCTGCTTTGGAACCAAGATTCTTGGGCGGTTTCGCTATCATCACAAAGTCTTTCGCTCGTATCCATGAAACTAACTTGAAAAAACAAGGTCTATTGCCATTGAACTTCAAGAACCCAGCTGACTATGACAAGATCAACCCTGATGACAGAATCGATATTCTGGGTCTAGCTGAATTGGCTCCAGGTAAGCCTGTAACAATGAGAGTTCATCCAAAGAATGGTAAGCCATGGGATGCTGTGTTGACCCATACTTTCAACGATGAGCAAATTGAATGGTTCAAATATGGTTCTGCCTTAAATAAAATTAAGGCCGATGAGAAGAAATAA","protein_sequence":"MLSARSAIKRPIVRGLATVSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHCDHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAAHGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQRGYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIKADEKK"},{"created_at":"2011-05-24T20:38:51.000Z","updated_at":"2011-05-29T05:06:14.000Z","name":"Probable aconitate hydratase 2","uniprot_id":"P39533","uniprot_name":"ACON2_YEAST","enzyme":true,"transporter":false,"gene_name":"ACO2","num_residues":789,"molecular_weight":"86582.5","theoretical_pi":"6.95","general_function":"Involved in metabolic process","specific_function":"Citrate = isocitrate","reactions":[{"id":2332,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm.","altext":"Citrate = isocitrate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X77688","genbank_protein_id":"547592","gene_card_id":"ACO2","chromosome_location":"chromosome 10","locus":"YJL200C","synonyms":["Aconitase","Citrate hydro-lyase"],"enzyme_classes":["4.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" aconitate hydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"}],"gene_sequence":"ATGCTATCTTCAGCTAATAGGTTTTATATAAAGAGGCATTTGGCAACACATGCCAATATGTTCCCCTCTGTATCTAAAAATTTTCAAACAAAAGTGCCACCTTATGCAAAACTTTTGACCAACCTAGACAAGATTAAACAAATAACAAACAATGCTCCATTGACACTAGCAGAAAAAATTTTATACTCGCATCTTTGCGATCCTGAAGAATCGATTACTTCTTCTGATCTGTCCACCATCCGTGGTAATAAATACTTGAAGCTAAACCCAGACCGTGTAGCTATGCAGGACGCTTCTGCCCAAATGGCGCTTCTACAATTCATGACCACCGGTCTAAATCAAACATCTGTCCCAGCATCCATACATTGTGATCATTTAATTGTAGGTAAGGACGGTGAAACTAAAGATTTACCCTCTTCCATAGCTACCAACCAAGAAGTTTTCGATTTCTTGGAGAGTTGCGCAAAGAGATATGGAATTCAATTCTGGGGCCCAGGTTCTGGTATCATTCACCAGATTGTTTTGGAAAATTTCTCAGCTCCAGGTCTAATGATGCTAGGTACTGATTCCCATACACCAAATGCAGGCGGTCTGGGAGCTATTGCCATCGGGGTTGGTGGTGCGGATGCAGTTGATGCCCTCACAGGCACTCCATGGGAATTAAAAGCACCAAAAATTTTAGGTGTTAAATTGACCGGAAAGTTAAACGGATGGTCCACTCCTAAAGATGTAATCACAAAGCTCGCTGGTTTACTAACTGTCAGAGGTGGTACTGGTTATATCGTCGAGTACTTCGGCGAAGGTGTATCCACTCTATCTTGCACAGGTATGGCAACCATCTGTAATATGGGAGCTGAAATCGGTGCTACAACGTCAACTTTCCCTTACCAAGAAGCTCACAAGCGTTATTTGCAAGCAACTAATAGAGCAGAGGTCGCTGAAGCAGCTGATGTTGCTTTAAACAAGTTTAACTTCTTAAGAGCCGACAAAGATGCTCAATACGATAAAGTTATTGAAATTGACTTATCCGCAATTGAACCTCACGTTAATGGTCCATTTACACCAGACCTTTCAACCCCAATATCTCAATATGCCGAAAAAAGTTTGAAGGAAAACTGGCCCCAAAAAGTTAGCGCTGGTTTGATTGGATCATGTACCAATTCATCTTATCAAGACATGAGTCGTGTTGTCGACTTGGTCAAGCAAGCTTCCAAAGCCGGCTTGAAACCACGTATCCCCTTCTTTGTCACCCCTGGTTCAGAACAAATTAGAGCTACCTTGGAAAGAGATGGAATCATCGATATTTTCCAAGAAAATGGTGCCAAAGTTTTAGCAAATGCATGCGGCCCTTGTATCGGACAATGGAATAGGGAAGATGTCTCGAAAACATCAAAAGAAACGAACACTATTTTTACATCATTCAATAGAAATTTCAGAGCTAGAAACGATGGTAATAGGAATACAATGAATTTCTTAACATCCCCAGAAATAGTAACAGCGATGAGTTATTCTGGAGATGCTCAGTTCAATCCGCTAACTGACTCAATTAAATTGCCAAATGGGAAGGATTTCAAATTCCAACCACCAAAGGGTGATGAGTTACCAAAAAGAGGATTTGAACACGGTAGAGACAAATTTTATCCTGAAATGGATCCAAAGCCAGATAGCAATGTAGAGATTAAGGTAGACCCTAATTCTGATCGTTTGCAATTATTAGAGCCATTCAAACCTTGGAACGGGAAGGAATTGAAGACAAACGTGCTTTTGAAAGTTGAAGGTAAATGTACAACAGATCATATTTCCGCTGCGGGCGTCTGGTTGAAATATAAAGGCCATCTAGAAAACATTTCTTACAATACATTGATTGGTGCACAAAACAAAGAAACCGGTGAAGTCAACAAGGCTTATGACCTTGACGGAACTGAATATGATATTCCTGGTTTGATGATGAAATGGAAATCAGACGGTAGACCATGGACCGTGATAGCGGAACATAACTATGGTGAAGGTTCCGCAAGAGAGCATGCTGCTTTGTCACCAAGATTTTTAGGCGGAGAGATTCTTTTAGTTAAGTCTTTTGCAAGAATTCATGAGACAAACTTGAAGAAACAAGGTGTGTTGCCATTGACTTTTGCCAACGAATCTGACTATGATAAAATATCAAGCGGAGATGTTTTAGAAACGTTGAACCTAGTTGACATGATTGCTAAGGATGGTAATAACGGTGGTGAAATTGATGTTAAAATTACTAAACCAAACGGTGAATCGTTCACCATCAAGGCAAAACATACTATGTCTAAAGATCAAATCGATTTTTTCAAAGCTGGTTCAGCAATCAATTATATTGGTAATATACGAAGAAACGAATAA","protein_sequence":"MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE"},{"created_at":"2011-05-26T16:05:55.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Citrate synthase 3","uniprot_id":"P43635","uniprot_name":"CISY3_YEAST","enzyme":true,"transporter":false,"gene_name":"CIT3","num_residues":486,"molecular_weight":"53810.69922","theoretical_pi":"8.79","general_function":"Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer","specific_function":"Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA","reactions":[{"id":1151,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1411,"direction":"\u003e","locations":"mitochondrion;peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2408,"direction":"\u003e","locations":"Peroxisome;Mitochondrion matrix","altext":"Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2409,"direction":"\u003e","locations":null,"altext":"propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA","export":false,"pw_reaction_id":null,"source":null},{"id":3697,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U31900","genbank_protein_id":"939735","gene_card_id":"CIT3","chromosome_location":"chromosome 16","locus":"YPR001W","synonyms":[],"enzyme_classes":["2.3.3.1","2.3.3.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" cellular carbohydrate metabolic process"}],"pfams":[{"name":"Citrate_synt","identifier":"PF00285"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA 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process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" cellular carbohydrate metabolic process"}],"pfams":[{"name":"Citrate_synt","identifier":"PF00285"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glyoxylate 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transport protein","uniprot_id":"P38152","uniprot_name":"TXTP_YEAST","enzyme":false,"transporter":true,"gene_name":"CTP1","num_residues":299,"molecular_weight":"32173.0","theoretical_pi":"10.08","general_function":"Involved in binding","specific_function":"Transport of citrate across inner mitochondrial membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"16-36;66-86;113-133;174-193;215-235;272-291","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"U17503","genbank_protein_id":"642520","gene_card_id":"CTP1","chromosome_location":"chromosome 2","locus":"YBR291C","synonyms":["Citrate transport protein","CTP"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell 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transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCCAGTAAAGCTACCAAAAGTGACGTAGATCCATTGCACTCGTTTCTGGCAGGGTCCCTAGCCGGTGCTGCTGAAGCATGTATAACATATCCTTTTGAATTTGCCAAAACAAGGCTGCAGCTGATTGATAAGGCCTCCAAGGCATCAAGAAATCCTCTGGTATTGATATATAAAACTGCAAAAACTCAGGGCATTGGTTCCATTTATGTCGGATGTCCCGCATTTATTATTGGTAACACCGCTAAGGCGGGTATTAGATTTCTTGGCTTTGATACCATTAAAGACTTGCTAAGAGATAGGGAAACTGGAGAACTAAGTGGTACAAGAGGGGTGATAGCTGGGTTAGGTGCGGGACTATTAGAAAGTGTTGCCGCAGTGACTCCTTTTGAAGCAATCAAAACTGCTTTGATCGATGATAAACAATCTGCTACACCAAAATACCATAATAATGGGCGCGGTGTAGTACGAAACTATTCATCATTAGTCCGTGATAAAGGATTTTCTGGTCTTTATCGTGGTGTTTTGCCAGTTTCCATGAGACAGGCCGCAAACCAAGCCGTTAGATTGGGTTGTTACAATAAGATTAAGACCTTGATCCAAGATTATACGGATTCGCCAAAAGACAAACCTTTATCATCCGGGTTAACCTTCTTAGTGGGTGCATTTAGTGGTATTGTGACGGTCTATTCCACCATGCCCCTTGATACTGTGAAAACAAGAATGCAAAGTTTGGATTCCACCAAATACTCCTCTACAATGAATTGTTTTGCAACCATTTTCAAAGAAGAAGGTTTAAAGACGTTTTGGAAAGGTGCTACGCCTAGACTTGGGAGATTGGTCTTGAGTGGTGGTATTGTTTTCACTATCTATGAAAAGGTCTTAGTTATGCTAGCCTGA","protein_sequence":"MSSKATKSDVDPLHSFLAGSLAGAAEACITYPFEFAKTRLQLIDKASKASRNPLVLIYKTAKTQGIGSIYVGCPAFIIGNTAKAGIRFLGFDTIKDMLRDSETGELSGTRGVIAGLGAGLLESVAAVTPFEAIKTALIDDKQSATPKYHNNGRGVVRNYSSLVRDKGFSGLYRGVLPVSMRQAANQAVRLGCYNKIKTLIQDYTDSPKDKPLSSGLTFLVGAFSGIVTVYSTMPLDTVKTRMQSLDSTKYSSTMNCFATIFKEEGLKTFWKGATPRLGRLVLSGGIVFTIYEKVLVMLA"}]}