tRNA (uridine-2'-O-)-methyltransferase TRM7 (P38238)

Identification
NametRNA (uridine-2'-O-)-methyltransferase TRM7
SynonymsNot Available
Gene NameTRM7
Enzyme Class
Biological Properties
General FunctionInvolved in methyltransferase activity
Specific FunctionMethylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00198S-AdenosylhomocysteineShow
YMDB00297S-AdenosylmethionineShow
GO Classification
Component
Not Available
Function
methyltransferase activity
binding
nucleic acid binding
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular metabolic process
cellular macromolecule metabolic process
RNA metabolic process
ncRNA metabolic process
one-carbon metabolic process
methylation
rRNA metabolic process
rRNA processing
rRNA modification
metabolic process
rRNA methylation
macromolecule metabolic process
Gene Properties
Chromosome Locationchromosome 2
LocusYBR061C
Gene Sequence>933 bp ATGGGTAAGAGCAGCAAAGATAAAAGAGATTTGTACTATAGAAAAGCAAAAGAGCAGGGC TATAGGGCTAGATCTGCTTTCAAACTACTTCAACTCAATGACCAATTTCATTTCCTGGAT GATCCAAACTTAAAAAGAGTTGTAGATTTGTGTGCAGCACCAGGTTCATGGTCACAAGTG CTCTCGAGAAAACTGTTTGATGAAAGTCCCAGTTCAGATAAGGAGGACAGGAAAATTGTC TCTGTCGATTTACAACCGATGTCCCCCATACCTCATGTGACAACGTTGCAAGCCGATATC ACTCATCCTAAAACATTGGCGAGGATTCTAAAACTGTTTGGCAACGAAAAGGCCGATTTT GTTTGTAGTGATGGTGCACCTGATGTTACTGGGTTACACGATCTTGACGAATACGTGCAA CAACAGTTAATTATGAGTGCGCTGCAACTTACTGCATGCATTCTGAAAAAAGGTGGAACT TTTGTGGCAAAGATCTTCAGAGGTCGTGATATAGATATGCTATATTCCCAATTGGGCTAT CTATTCGATAAAATCGTTTGCGCAAAGCCAAGATCATCAAGAGGTACATCTCTGGAAGCT TTTATTGTTTGTTTAGGCTATAACCCACCATCCAATTGGACACCAAAATTAGATGTAAAT ACATCCGTTGATGAATTTTTTCAAGGCTGTTTTTTGAATAAATTGTGTATATCAGACAAA TTGTCTCATTGGAATGAAGAGGAGAGAAACATAGCCGAATTTATGGCTTGTGGAAGTCTT CAAAGTTTCGACTCAGATGCCACTTATCATGACCTACCTTCTTCGGTTGCAGGCACTTCA TCGTCCTTAGATCCTGTTCAAAGCCCGACGAACCCTCCCTACAAGAAAGCTTTGGAATTA AAAAGGAGCGGGAAACTCACTAGATCAGTTTGA
Protein Properties
Pfam Domain Function
Protein Residues310
Protein Molecular Weight34700.19922
Protein Theoretical pI7.99
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>tRNA (uridine-2'-O-)-methyltransferase TRM7 MGKSSKDKRDLYYRKAKEQGYRARSAFKLLQLNDQFHFLDDPNLKRVVDLCAAPGSWSQV LSRKLFDESPSSDKEDRKIVSVDLQPMSPIPHVTTLQADITHPKTLARILKLFGNEKADF VCSDGAPDVTGLHDLDEYVQQQLIMSALQLTACILKKGGTFVAKIFRGRDIDMLYSQLGY LFDKIVCAKPRSSRGTSLEAFIVCLGYNPPSNWTPKLDVNTSVDEFFQGCFLNKLCISDK LSHWNEEERNIAEFMACGSLQSFDSDATYHDLPSSVAGTSSSLDPVQSPTNPPYKKALEL KRSGKLTRSV
References
External Links
ResourceLink
Saccharomyces Genome Database TRM7
Uniprot IDP38238
Uniprot NameTRM7_YEAST
GenBank Gene IDZ35930
Genebank Protein ID536303
General Reference
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Pintard, L., Lecointe, F., Bujnicki, J. M., Bonnerot, C., Grosjean, H., Lapeyre, B. (2002). "Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop." EMBO J 21:1811-1820.11927565
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106