Iron-responsive element-binding protein 2 (Q6NTP2)

Identification
NameIron-responsive element-binding protein 2
Synonyms
  • IRE-BP 2
Gene Nameireb2
Enzyme ClassNot Available
Biological Properties
General Functionmetabolic process
Specific FunctionRNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Cellular LocationNot Available
SMPDB Pathways
Citric Acid CyclePW000952 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
metal ion binding
cytoplasm
4 iron, 4 sulfur cluster binding
iron-responsive element binding
translation repressor activity
cellular iron ion homeostasis
iron ion transport
metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>3477 bp GGCGTATGCGAGAGGAGATAGGGAAAGTGAGACAGCCACTGGGAAACTGAACAGCGAAAG AGAAGTTTGGAAGCACAAGCAGATTTCAGCCAAAATGACAGAGAACCCATTTCACTATTT AGTGGAGACATTGTCTGGAACATCTGACAAGACATTTTTCAATGTGTCTAAACTGAAGGC CACTGAATATGATTCTTTGCCTTACTGTATACGTGTTGTACTGGAGGCTGTGGTGCGAAA CTGTGATGGAGTCTTGGTAAAGGAACAAGATGCCTTTAACATTTTAAATTGGAAGACTAA ATGTGAATTCAAAGAGATTCCTTTCTTGCCTGCTCGTGTCATGCTGCAAGATTTTACTGG TATACCGGCAATGGTGGATTTTGCTGCAATGAGAGATGCCATCAGCAAGTTTGGAAAAGA TCCTAAGCAGGTGAATCCTGCCTGTCCCACAGACCTCATAGCTGATCATTCTCTGCAGCT GGATTTCACTAAATGTATTGCTGCACAGAATGTTTCAGGTTTACCCGCAGTTGAGACACA CAGACCAACCACAACACCTGGGAAAACACCTGGGCGAAAAGCCCAGTGTAGAAGTCAGGG CGGATGCAAAGGAGCCTGTGATTTGGGAGCAGCAAATGGAAGCTCCAGGGAACAAATTGA GAATACTCCAATGTTGTGCCCTTTTCATCTGCAGCCCATTGCCGAGCCAGAAACAGCATT AAAAAGTCTTGAGATAGAGTTTAACCGGAATAAAGAGCGGCTACAGTTTTTTAAGTGGTG TTCCAAAGCTTTCCAGAATGTTGCTGTGATCCCACCAGAGACCGGGACAGTACATCAGGT TAACCTGGAGTTTTTATCACGGGTGGTGATGGAAGAAAAGGGTTGCATATATCCAGATAG TGTTCTTGGTACTGACTCTCATACCACAATGGTAAATGGCCTTGGGATTTTAGGGCTTGG TGTGGGTGGAATAGAGTCTGAAGCAGCAATGCTAGGAGTTCCTATTACCCTGACCTTGCC AGAGGTGGTTGGCTGTGAACTAACTGGCACTATTAACCCTATTGCCACATCTATAGATGT TGTTTTAAGCATCACAAAGCATCTGAAACAAGCTGGTGTTGCAGGCACATTTGTGGAGTT CTTTGGGAATGGGGTTTCTCAGTTGTCTGTTGCGGACCGCACTACTATAGCCAACATGTG CCCAGAGTATGGTGCAACAGTGGCATTCTTCCCCGTGGACAGTGTAACCCTGCAGCACTT AAAGCAGACAGGAGTTGATCTGCAGTGTGTCAAGACATTTGAGAACTATCTGAAAGCTGT TAAATTACTGCGGCAGGAGAATGTGCAGCAACCTCTATATTCCAAGGTCCTTCAAATTAA CCTGAATTCCATTGTCCCTTACGTGAGTGGTCCTAAGAGGCCCCAAGACAGGATATCTGT GATGGATATGAAGAAAGATTTTGAGACCTGTCTGAAGGAAAAGACTGGTTTAAAAGGATT TCAAATACCAGAAGAGAAGCAAAATATAATGGTCCCAGTGACATATGGAAATTCTGAATA CTCTCTGTCACATGGCTGTGTTGTCATTGCTGCAGTTACAAGCTGCACCAACAACTGTAA CCCCTCTGTCATGCTGACTGCAGGTTTATTAGCCAAAAAGGCAGTTGAGGCTGGACTGAC TGTAAAGCCATACATAAAAACTAGCCTTTCTCCTGGGAGTGGAACTGTAACATACTACCT CAGTGCTAGTGGTGTGTTGCCCTATCTAAGCAAGCTGGGGTTTGATATCATTGGTTATGG CTGTGCTAGATGTGTGGGAAATACCAACCCTTTACCAGAGAGTATTGTCACCGCCATTAA AGAGGGAGAGCTTGTGGCATGTGGTGTTTTTTCAGGAAACAAACACTTTGAGGGAAATCG CTGTAGCTGTGTTTGTGCAAACTATCTGGCTTCCCCACCTTTAGTAGTGGCATATGCCTT GGCAGGCACTGTCAACATAGATCTGCAGACTGAACCTTTGGGTGAAAATGCACAAGGTAA AAAGATTTTTCTGCAAGATATTTGGCCTAGCCGGGAGGAGGTTTTGGAGGTCGAAGAAAC CTTGGTGATTCCATCTATGTTCAGTGAACTGAAACTGAAAATAGAGAAACAAAATACACG ATGGAACTTACTGGATGCCCCTGAAAGCACTTTATTCCCCTGGGATCTCCGGTCCACATA TATCAGAAGCCCACCCTTTTTCCATAAATTAGAGAAAATCCCCCCACCCATTCAGCCCAT TGAGAGAGCCTATGTATTACTTTATTTAGGAGATTCAGTGACAACTGACCACATGTCACC TGCAGGAAGTATTCCTCGGACTAGCCCAGCGGCTAAGTACTTAATGCAGAAGAATCTGGT TCCCCGGGAGTTTAATTCATATGGAGCCCGGAGAGGTAATGATGCTGTGATGACACGAGG GACTTTTGCTAATATGAAGCTATTCAATAAGCTTGTTGGCAAAACTGGACCCAAAACCAT CCATTTACCATCAGGACAAACTATGGATGTTTTTGATGCTGCAGAACTTTATCAAAGATC AGAAATTCCCCTCATAATTATAGCTGGGAAAAAGTATGGACTTGGTAATTCTAGAGACTG GGCTGCTAAAGGACCTTTTTTGCTGGGTGTCAGAGTGGTGATAGCTGAAAGCTATGAGAA AATCCATAAAGACCACTTAGTGGGTATGGGTATCGCACCACTTCAATTTCTTAGTGGGGA AAATGCAGAAACCCTGGGCCTTTCCGGGAAAGAGCAGTATTCATTATCGCTTCCGGTCGA TCTGACTCCTGGACACAAAGTAGAAATTAAGACAAACACTGGGAAGATTTTCCATGTGAT TGCAGCCTTTGACAATGAAGCAGAAGTCACTTTGTATAAACATGGAGGAATATTAAGCTA TGTGGCACGGAAATATTTATAGTAGAGTTTAGGAATCGGGATGGTAAAGTCAAAATGACA TTTCTCCTCCTGCTCTTTTACTTCTTACCTCCAGCAGATATGGGTTACTGAAAAGGAGTA AGTGAAACCTTTTCTGGCTCTTTCTTTTCAAGACTGGTGCTATGGACATGCCTTTTTTTT TTTTAAACTGCCTGAAGGGAAGAAATGATTTCCAACCTGATCACATGTAGTTGCAGAGAA ACTTACCAGAGAAGACTGGGAATGCAGTTATGAAGTGGTGCTCAGTTTTTCTCTGTAAAA CCTGTAACTGCTATTTCATAAACTTCCAGCAGTAGTTTTCAGAATAAATGGTGACTTTGT ATTTAAAACAAAGATAGATTTATCCGAAAACTTTCCATTTGATGAGGTTTTGTTTCATGG ATCTGAAGAAAAAAAAAACACATTGCTATGGACATATTATTCACAGCACTATCAGTGTTG CATATGACAAGAATGAAATAAAGCTTATAAAACACAAAAAAAAAAAAAAAAAAAAAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues955
Protein Molecular Weight104435.73
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Iron-responsive element-binding protein 2 MTENPFHYLVETLSGTSDKTFFNVSKLKATEYDSLPYCIRVVLEAVVRNCDGVLVKEQDA FNILNWKTKCEFKEIPFLPARVMLQDFTGIPAMVDFAAMRDAISKFGKDPKQVNPACPTD LIADHSLQLDFTKCIAAQNVSGLPAVETHRPTTTPGKTPGRKAQCRSQGGCKGACDLGAA NGSSREQIENTPMLCPFHLQPIAEPETALKSLEIEFNRNKERLQFFKWCSKAFQNVAVIP PETGTVHQVNLEFLSRVVMEEKGCIYPDSVLGTDSHTTMVNGLGILGLGVGGIESEAAML GVPITLTLPEVVGCELTGTINPIATSIDVVLSITKHLKQAGVAGTFVEFFGNGVSQLSVA DRTTIANMCPEYGATVAFFPVDSVTLQHLKQTGVDLQCVKTFENYLKAVKLLRQENVQQP LYSKVLQINLNSIVPYVSGPKRPQDRISVMDMKKDFETCLKEKTGLKGFQIPEEKQNIMV PVTYGNSEYSLSHGCVVIAAVTSCTNNCNPSVMLTAGLLAKKAVEAGLTVKPYIKTSLSP GSGTVTYYLSASGVLPYLSKLGFDIIGYGCARCVGNTNPLPESIVTAIKEGELVACGVFS GNKHFEGNRCSCVCANYLASPPLVVAYALAGTVNIDLQTEPLGENAQGKKIFLQDIWPSR EEVLEVEETLVIPSMFSELKLKIEKQNTRWNLLDAPESTLFPWDLRSTYIRSPPFFHKLE KIPPPIQPIERAYVLLYLGDSVTTDHMSPAGSIPRTSPAAKYLMQKNLVPREFNSYGARR GNDAVMTRGTFANMKLFNKLVGKTGPKTIHLPSGQTMDVFDAAELYQRSEIPLIIIAGKK YGLGNSRDWAAKGPFLLGVRVVIAESYEKIHKDHLVGMGIAPLQFLSGENAETLGLSGKE QYSLSLPVDLTPGHKVEIKTNTGKIFHVIAAFDNEAEVTLYKHGGILSYVARKYL
References
External Links
ResourceLink
Saccharomyces Genome Database ireb2
Uniprot IDQ6NTP2
Uniprot Nameireb2
General ReferenceNot Available