| Identification |
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| Name | Serine/threonine-protein kinase PKH2 |
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| Synonyms | - PKB-activating kinase homolog 2
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| Gene Name | PKH2 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | regulation of nuclear-transcribed mRNA poly(A) tail shortening |
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| Specific Function | Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step. |
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| Cellular Location | Not Available |
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| SMPDB Pathways | | Stress-activated signalling pathways: cell wall stress test 1 | PW007861 |    |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | |
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| GO Classification | | Function |
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| cytoplasmic mRNA processing body assembly | | regulation of nuclear-transcribed mRNA poly(A) tail shortening | | protein kinase activity | | late endosome to vacuole transport via multivesicular body sorting pathway | | ATP binding | | nucleus | | protein serine/threonine kinase activity | | peptidyl-serine phosphorylation | | MAPK cascade involved in cell wall organization or biogenesis | | protein phosphorylation | | cell cortex | | endocytosis |
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >3246 bp
ATGTATTTTGATAAGGATAATTCCATGAGCCCTAGGCCGTTATTGCCAAGTGATGAGCAG
AAGCTAAACATTAATCTTCTAACGAAAAAGGAGAAATTCTCGCATTTAGACCCCCATTAT
GACGCAAAAGCCACTCCACAAAGAAGCACTTCGAATAGAAACGTTGGCGATTTACTTTTG
GAAAAAAGAACCGCTAAGCCTATGATTCAAAAGGCCTTGACGAATACGGATAATTTCATT
GAAATGTACCATAATCAGCAGAGAAAAAATCTTGATGATGACACTATTAAAGAAGTAATG
ATTAATGATGAAAACGGAAAAACTGTCGCTAGTACCAACGACGGCAGATATGACAACGAT
TACGATAATAACGATATTAATGACCAAAAAACTTTGGATAATATAGCGGGAAGTCCCCAC
ATGGAAAAAAATCGAAACAAAGTAAAGATTGAACATGACTCTTCATCTCAAAAACCAATA
GCTAAAGAGTCATCCAAAGCCCAAAAAAATATAATCAAAAAGGGAATCAAGGACTTTAAA
TTTGGTAGTGTAATAGGTGATGGCGCGTATTCTACTGTAATGTTAGCGACGTCGATTGAT
ACCAAAAAGAGGTACGCCGCAAAAGTACTAAACAAAGAATATTTAATACGCCAGAAGAAA
GTCAAATACGTCAGCATAGAAAAAACCGCCCTTCAAAAGCTCAATAATTCTCCTAGTGTT
GTGCGATTATTTTCCACTTTTCAGGATGAATCAAGCCTATACTTTCTCTTAGAGTATGCC
CCCAATGGGGACTTTCTTTCTTTAATGAAAAAATACGGTTCATTAGACGAAACCTGCGCA
CGATATTATGCTGCGCAAATAATAGATGCCATAGACTACTTACATTCCAACGGTATTATT
CATAGAGATATAAAACCAGAAAATATTCTTTTAGATGGAGAAATGAAGATCAAACTGACT
GATTTTGGTACTGCGAAGTTACTGAATCCTACAAATAATAGCGTTTCGAAACCAGAATAC
GATTTATCAACAAGGTCGAAATCTTTCGTTGGAACTGCAGAATACGTATCTCCAGAACTT
TTAAATGACAGTTTTACAGACTATCGTTGCGATATTTGGGCCTTCGGATGTATACTTTTC
CAGATGATTGCCGGAAAACCACCATTCAAAGCTACCAATGAATACTTGACTTTCCAAAAG
GTAATGAAAGTTCAGTACGCCTTTACACCAGGTTTCCCACTTATTATCAGAGATTTGGTT
AAGAAAATCTTAGTAAAAAACTTAGACCGAAGATTGACGATAAGCCAAATTAAGGAACAT
CATTTTTTCAAAGATTTGAATTTTAAAGACGGCTCTGTTTGGTCAAAAACGCCTCCAGAG
ATCAAACCATATAAAATCAACGCCAAATCCATGCAGGCAATGCCAAGCGGAAGCGATAGA
AAACTGGTGAAGAAATCAGTCAACACACTTGGCAAATCGCATCTAGTGACTCAAAGGTCA
GCTTCAAGTCCCTCTGTTGAGGAAACTACTCATTCAACCCTATACAATAACAATACTCAC
GCTTCTACTGAAAGTGAAATATCAATAAAGAAGAGACCCACTGATGAAAGAACAGCGCAG
ATACTTGAAAATGCAAGAAAGGGTATAAACAATAGGAAAAATCAACCAGGCAAGAGAACA
CCAAGTGGTGCAGCTTCTGCTGCCCTAGCAGCTTCTGCTGCTTTAACCAAGAAAACCATG
CAAAGCTATCCAACTTCTAGTTCGAAAAGTAGCAGGTCAAGCTCTCCTGCGACAACATCA
AGACCAGGAACTTATAAGCGTACTTCTTCTACAGAAAGTAAACCATTTGCCAAATCTCCA
CCTTTGTCAGCATCAGTTTTATCGTCAAAAGTCCCAATGCCTCCATACACACCTCCAATG
TCGCCCCCTATGACACCATATGATACATATCAAATGACACCTCCCTATACGACAAAACAG
CAGGATTATTCTGATACCGCAATTGCCGCACCTAAGCCTTGTATTAGTAAGCAAAATGTT
AAAAATAGCACAGATTCTCCCTTGATGAACAAGCAAGATATTCAATGGTCCTTTTACCTG
AAAAACATCAACGAACATGTACTAAGGACGGAAAAACTGGATTTTGTTACCACAAATTAC
GATATCTTAGAGAAGAAAATGCTTAAACTAAATGGTTCATTGTTAGATCCTCAACTGTTT
GGTAAGCCTAGACATACTTTTTTATCCCAAGTAGCTAGGAGTGGGGGAGAGGTTACAGGT
TTTCGAAATGATCCAACTATGACTGCTTATTCCAAAACAGAAGATACGTACTATTCGAAA
AATATTATCGATTTGCAGCTCTTGGAAGATGATTATCGAATTGAAGGAGGTGACTTATCG
GAGTTGCTTACTAACAGAAGCGGAGAAGGGTACAAATGCAATCAAAACAGCTCACCAATG
AAAGACGATGATAAATCCGAATCTAACAATAAAGGAAGCTCTGTTTTTTCTGGCAAGATT
AAAAAATTATTTCACCCTACCTCAGCAGCTGAAACGCTCTCTTCCTCTGATGAAAAAACC
AAGTACTATAAACGAACCATTGTAATGACATCATTTGGAAGGTTTCTAGTATTTGCCAAG
AGGAGGCAGCCAAATCCAGTTACAAATTTAAAGTATGAACTAGAATATGACATAAATTTG
CGTCAACAGGGTACCAAAATAAAAGAACTAATCATTCCCTTGGAAATGGGAACTAATCAT
ATAGTTGTGATTCAGACACCTTACAAGTCATTTCTTTTGAGCACTGATAAAAAAACCACG
AGCAAATTGTTTACTGTTCTCAAAAAAATTCTTAATTCGAATACAAATAAAATAGAGAAA
GAACTGTTGCAAAGAAACCAAAAGGTAATTGAAAGAAGAACATCATCATCCGGAAGAGCC
ATACCTAAAGATCTTCCAACTTCCAAGTCTCCTTCGCCAAAACCCAGGACGCATAGCCAA
TCTCCATCAATTTCAAAGCACAATTCGTTTTCTGAATCGATTAATAGCGCTAAGAGCAAC
AGATCAAGCAGAATTTTTGAAACCTTTATCAATGCCAAGGAACAAAATTCAAAAAAACAC
GCTGCTCCAGTACCGTTAACCAGTAAATTAGTTAACGGATTGCCAAAAAGACAAGTTACC
GTGGGATTAGGTCTAAACACAGGAACAAATTTCAAAAACTCATCTGCAAAATCGAAGAGG
TCGTAA |
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| Protein Properties |
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| Pfam Domain Function | Not Available |
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| Protein Residues | 1081 |
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| Protein Molecular Weight | 121659.06 |
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| Protein Theoretical pI | Not Available |
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| Signalling Regions | Not Available |
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| Transmembrane Regions | Not Available |
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| Protein Sequence | >Serine/threonine-protein kinase PKH2
MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLL
EKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDND
YDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFK
FGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSV
VRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGII
HRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPEL
LNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLV
KKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDR
KLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQ
ILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTS
RPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQ
QDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNY
DILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSK
NIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKI
KKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINL
RQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEK
ELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSN
RSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKR
S |
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| References |
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| External Links | | Resource | Link |
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| Saccharomyces Genome Database | PKH2 | | Uniprot ID | Q12236 | | Uniprot Name | PKH2 |
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| General Reference | Not Available |
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