You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Identification |
---|
Name | Probable ferric reductase transmembrane component 8 |
---|
Synonyms | - Ferric-chelate reductase 8
|
---|
Gene Name | FRE8 |
---|
Enzyme Class | |
---|
Biological Properties |
---|
General Function | Involved in iron ion binding |
---|
Specific Function | Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis |
---|
Cellular Location | Membrane; Multi-pass membrane protein |
---|
SMPDB Pathways | Not Available |
---|
KEGG Pathways | Not Available |
---|
SMPDB Reactions | Not Available |
---|
KEGG Reactions | Not Available |
---|
Metabolites | YMDB ID | Name | View |
---|
YMDB00110 | NAD | Show | YMDB00143 | NADH | Show | YMDB00194 | Iron(3+) | Show | YMDB00379 | Iron(2+) | Show |
|
---|
GO Classification | Component |
---|
cell part | membrane part | intrinsic to membrane | integral to membrane | Function |
---|
FAD or FADH2 binding | ion binding | cation binding | metal ion binding | transition metal ion binding | iron ion binding | oxidoreductase activity | catalytic activity | electron carrier activity | binding | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | Process |
---|
Not Available |
|
---|
Gene Properties |
---|
Chromosome Location | chromosome 12 |
---|
Locus | YLR047C |
---|
Gene Sequence | >2061 bp
ATGAATTTAAAGTCCATCGTTAGCTGGTTCAAGGAACATCTTCCCAGTTTTGATGTCGAC
GTGGACAAGCATTTTAGAACTTTAAGAGTCCGCAAATATTCTCAGATATGTCTTTTAATT
TCTTTCATTATAATATGTGTTATTATACCCTTAATGAATTATTTGTTGCTAACTGACAAA
TTCTTCAAAATATGTCACCATTTAAAGCATCATGTTTTCAACAGAAGATCATGGGTTCAC
AAAACACATATGTATCACAAACAGTCACTACAACTATGTTTAATATGCTTTGTTTTCACC
TCGTTTTTTGTTATACAAGGCGCTAACGGAGATCTGTTAGAAATTACTAAGCGAATGGGG
AGAATTTCCGTTGCTTTGATGCCACCTTTACTATTTCTAACGTTGAGGCCATCACCGTTA
CCTCACACGTTATACTTAGCATTGTTACCTCTCCACAAATGGATTTCCAGAATTGTTGTG
CTTGAATCTATTCTACACACGTGGTTCTATCTCTATTACATGTACATTAATGATACGTTA
TACGTGAAAATGAGAAAACTACCCAACATTTATGGGGTTATTGCCCTCGGCCTTTTCCTA
CTGATTGCCATCACCTCTGTGAGATATGCCAGACGATGGAGCTACAGAGTTTTTTACTAT
GTTCACTATGTAAGCACATGGCTTATTTTGGTGTTTCTACATTATCACGCTCGCCCAGGA
ATTTCATATTATACCACTTTAAATGTGCTCATATTAACGGGACAAATCGTCTATAGGCTC
CATATCACCAATGTTACGAGAGTTACGATAGTACCCATTTCTTCATCATTGTCTCTTTTG
GAGTTCCCATTAACCGATTTACCCAAAAAGCCCATCCTACCAGGAGGGCATCTAAGGATC
AACATTTACCATAGAAATTTTTTAAGGAGGTTTTTCTCCCATTTGATACCCTTCCAACAT
CCTTTTACTATTGCTAGTATTCCAAGTGATAATTTGGTCAGGTTAATTATTAGAAACGGG
CATTTTCCATTGCGTACAAATGAAAAGTATTACATTACAGGGGCTTTTGAACCTGAGTTG
AGTTTCATTTCTAAACCTACTGTTCCTTTTAATATTACCACGAAATCTTCCAAGAATCCA
TTTCGAAACAATTCTTCTGCACTAATAAATTCGCCTTTAAATTTTCTAATTAAAGCGCAA
AGAGTGTTTATGTGTGTTGGAGGTTCAGGAATTTCCTTTGGCTTACCACTACTTCGTATT
CTAAACTTCAACGGTGTAAACGTTAGGCTCCTTTGGGTTTCTAGAGATTATAAGGATCTG
GAAGTATTGAACCACTTCAAAAACAATTTTGAAGGTATGGAGATATATATTAGTGGCACC
GAAGGCAACGAACAGGACATAGAAATTGATTATATTGACTATCATGACTGCGCTGCTGAT
ATTAATGATGAAGTCAGGAGTATTTCTTCGAGCGGCCGAGTTTCAGAACTGGGAGATAAT
TCCATGTTATCAGATGGAAATCCCCAACCTACGGAGCCCAATGAGAACACAGCCCTTCTA
AGTAAGAAATCTACCTTGAGAAACCATCACCCACCAAAAACAAGTGATATACCTGACATC
AATGCTGATGACGAGATAGATTTTACATATGCTTTTAGCAGATCCAAATCAAGGAAAAAT
ACTGCACAAGGAACTCTAACTACACATTCTTCGTTTAACGGATCGAGCGTTTTCAGACAA
CCAAAGATCATTGAGCCACCTGCCCAAGATCCTTGTTTAGAGGCGGCGCCTAAAAAGATC
AGAATTCCCGCAGGTGTTAAAGTGTTCTTTGGCAGGCCTACACTTGGAGATAAGGATTAT
GAATGGTGTCTGCAAACCGAATGTGATGCAGAGACGGATTCTATTCAATGTTGCAGGTGG
GCGAATCAAGGCAGAGACCATGCTGAATATTTGTCACAAGTATGGGTTCTCGCTGCAGGC
CCTAGAGGCTTAATTGAAAGCACCAAAAGATGGGCGACAGATGGTGGTTTACACTTTCAC
GGAGAAAGTTTTGCATTATAA |
---|
Protein Properties |
---|
Pfam Domain Function | |
---|
Protein Residues | 686 |
---|
Protein Molecular Weight | 78947.70313 |
---|
Protein Theoretical pI | 9.43 |
---|
Signalling Regions | |
---|
Transmembrane Regions | - 36-56
- 90-110
- 129-149
- 158-178
- 187-207
- 217-237
- 268-288
- 403-423
|
---|
Protein Sequence | >Probable ferric reductase transmembrane component 8
MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDK
FFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMG
RISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTL
YVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPG
ISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRI
NIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPEL
SFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRI
LNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAAD
INDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDI
NADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKI
RIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAG
PRGLIESTKRWATDGGLHFHGESFAL |
---|
References |
---|
External Links | |
---|
General Reference | - Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
- De Freitas, J. M., Kim, J. H., Poynton, H., Su, T., Wintz, H., Fox, T., Holman, P., Loguinov, A., Keles, S., van der Laan, M., Vulpe, C. (2004). "Exploratory and confirmatory gene expression profiling of mac1Delta." J Biol Chem 279:4450-4458.14534306
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
|
---|