Osmolarity two-component system protein SSK1 (Q07084)

Identification
NameOsmolarity two-component system protein SSK1
SynonymsNot Available
Gene NameSSK1
Enzyme ClassNot Available
Biological Properties
General Functionpositive regulation of protein autophosphorylation
Specific FunctionFinal receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: low osmolarityPW002515 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
protein homodimerization activity
protein kinase activator activity
activation of MAPKKK activity involved in osmosensory signaling pathway
positive regulation of protein autophosphorylation
cytoplasm
positive regulation of actin cytoskeleton reorganization
phosphorelay response regulator activity
osmosensory signaling via phosphorelay pathway
mitogen-activated protein kinase kinase kinase binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2139 bp ATGCTCAATTCTGCGTTACTGTGGAAGGTTTGGCTACGAATAGACAACTCCACTGATGAA GTAAACCAACCAATTGCTGTACAGTTCGATGAAATAGATACTGTTGATGATTTGAAGAGC AGGTTTTTTCAGAAACTGAGTTCGACTCGATGGCGAGAAATTAACGATAATGCTTCCATT GCAATAGGCCTCTACGCACCTAAATTTGACAATCAAGCCGACAATACCAGTAGTAACAAC ACTAACGATAATAGTTGTCGAAGTAAGAGTAACGGTGCTGGAAGTGGCGCCAACCTTTCC GTTAATAGCAATACCAAGAGTTCAGTGAGCCCCACAGCAGGATCATTTGGTCTTTCAAAA GACCTTGCAAAGGACAGGAATGTTCTCCAGCATCCTAAACCTACGCAGAAAAGAGGAGCA TTATACGACGCCTTTGCCGCCGTGCCGACAGTGGCCGCGACTACCAATGTGGATTTTCCT CCCAACGAGGCGCCAATGCTAAGCCCGCAAAGACCATACTCTACTAGTCCTAAACAGTTT CCAGCAACAACTAAAAGTCCGTTACTGCGATTTGCCTCAGTCTCACCCTACCCTAAATTT CATTCTGATAATCAAATTATGGCATCAGCTGGTCTTACATACGTCTCACCGCATAATAAA AATAAATACACAAGGCCGTTGATTAGAAAAGGTTTAAATTTTACCACAGAATCAGTTAAT GATTGCACTTATAAAATCATCTTTGAACCGGATGAATTGGCTATTAACATATATAAGGAA CTATTCGGAACCATGGGTTCCCAACCTGCATCGCAGCCTTTGCTGATATTTTCGAATGTT AATTTACGCCAGGATGTACCGCCTTTAGATATCTTAAATGTTGTAGACTATGTTCCTACG AATGAAGAAATTTCGCAGCAGAAAACTCAACCAACAGACCATGGGGCCGTTGGTGTTTTT CATCTAGACGACCATATTTCTCCGGGCGAACAAGGTCTTAAGCAAACAATTGGTGATAAA GCAGATCTTAAAGGTAAAGATGGCAATAGCAGCCCTCAGGAATTTAAATTAATAACTGAT GAAGAGCAATTGAGAAGAGCGTCACAAGAACTGAAGGATGAGGAAAAGGATGCCGAGTCT CCTTGGCAAGCAATCTTGCTGTTACCAAAAGGTTATAAAGGAGGGGTAGATTTTCGAAAT AAACCAGTGGCCCACACGGATTCATCTTTCAATAATGAAGACACAATTACTCATTCAGAG TTAGAAGTGAACACCGGATCCCCTTCGCAAGAAAGCGGATCACTTAATGAAGCTGGTATA GGCATAACGCAACCCATGTCGGAAGTACAAAGAAGAAAAGAAGACGTTACGCCCGCATCA CCAATATTAACAAGTAGTCAAACGCCGCATTACTCAAACTCGCTTTATAACGCACCTTTT GCTGTTTCCTCTCCACCAGATCCTTTACCAAACCTTTTTACCACCACAAGTGAAAAAGTT TTCCCCAAAATTAATGTTTTAATAGTTGAAGACAACGTCATCAACCAAGCTATCTTAGGT TCCTTTCTGAGGAAACACAAAATCTCATATAAACTGGCTAAAAATGGTCAAGAAGCTGTT AATATTTGGAAGGAAGGCGGTCTTCATTTAATATTTATGGATTTACAGCTGCCTGTCTTG TCTGGTATAGAAGCTGCCAAGCAGATTAGGGACTTCGAAAAACAAAATGGCATTGGCATT CAAAAAAGTCTCAATAACTCACACTCCAATCTTGAAAAAGGTACTTCAAAGAGATTCTCT CAGGCGCCCGTGATTATTGTAGCATTGACCGCATCTAACTCTCAGATGGATAAAAGAAAA GCACTTCTTTCTGGTTGTAACGACTACCTGACTAAACCAGTGAATTTACACTGGCTTAGT AAGAAAATTACAGAGTGGGGATGTATGCAAGCCTTGATTGATTTTGACAGCTGGAAGCAG GGAGAAAGCCGGATGACCGACAGTGTTTTGGTTAAATCTCCACAGAAACCTATTGCACCT TCCAACCCTCACTCATTCAAACAAGCGACATCTATGACCCCTACACACAGCCCAGTAAGA AAAAATTCAAACCTCTCGCCCACTCAAATAGAATTGTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues712
Protein Molecular Weight78528.545
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Osmolarity two-component system protein SSK1 MLNSALLWKVWLRIDNSTDEVNQPIAVQFDEIDTVDDLKSRFFQKLSSTRWREINDNASI AIGLYAPKFDNQADNTSSNNTNDNSCRSKSNGAGSGANLSVNSNTKSSVSPTAGSFGLSK DLAKDRNVLQHPKPTQKRGALYDAFAAVPTVAATTNVDFPPNEAPMLSPQRPYSTSPKQF PATTKSPLLRFASVSPYPKFHSDNQIMASAGLTYVSPHNKNKYTRPLIRKGLNFTTESVN DCTYKIIFEPDELAINIYKELFGTMGSQPASQPLLIFSNVNLRQDVPPLDILNVVDYVPT NEEISQQKTQPTDHGAVGVFHLDDHISPGEQGLKQTIGDKADLKGKDGNSSPQEFKLITD EEQLRRASQELKDEEKDAESPWQAILLLPKGYKGGVDFRNKPVAHTDSSFNNEDTITHSE LEVNTGSPSQESGSLNEAGIGITQPMSEVQRRKEDVTPASPILTSSQTPHYSNSLYNAPF AVSSPPDPLPNLFTTTSEKVFPKINVLIVEDNVINQAILGSFLRKHKISYKLAKNGQEAV NIWKEGGLHLIFMDLQLPVLSGIEAAKQIRDFEKQNGIGIQKSLNNSHSNLEKGTSKRFS QAPVIIVALTASNSQMDKRKALLSGCNDYLTKPVNLHWLSKKITEWGCMQALIDFDSWKQ GESRMTDSVLVKSPQKPIAPSNPHSFKQATSMTPTHSPVRKNSNLSPTQIEL
References
External Links
ResourceLink
Saccharomyces Genome Database SSK1
Uniprot IDQ07084
Uniprot NameSSK1
General ReferenceNot Available