E3 ubiquitin-protein ligase PIB1 (Q06651)

Identification
NameE3 ubiquitin-protein ligase PIB1
Synonyms
  • Phosphatidylinositol-3-phosphate-binding protein 1
Gene NamePIB1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in phosphatidylinositol-3-phosphate binding
Specific FunctionFunctions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate
Cellular LocationEndosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
zinc ion binding
protein binding
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>861 bp ATGGTTATTAAAGAGGACTGTATCAATAATCTTGCCAGGTGGCAGGCAGACGAGGAAGCT CACAGCTGTTTTCAATGCAAGACGAACTTTTCGTTTCTCGTAAGAAGACACCATTGTAGG TGTTGTGGAAGGATATTTTGTTCGTCTTGTACCGAAAATTTTGTTAATTATAATAAAAAG AGAGTCCATGCCTTGCAGAAAAAAAATAGCGACGTGGAATCGCCTCCATATAGAACTTGT AATGAGTGCTACGATAACCTCCTTCATTTAAATCTACTAGTATCCTCCACCAACAGAGAT GTACGACTATCGCAAACTTCGGTACCACCAAATGCACTTGCACTTTCTGCACCAGATAGC AACACTGATGAAGACGCGGAAATCCTGGAAGATTCGGTAGATCAATCCGGTACGGCATGC AGGAGCGAAGAAAGTTCACAAAACGAGGAGGATCACTTCTGCCCTATTTGTAACTCAGAT CTCACACAGTTTCCTGGTGAAGAAGAGACCAGAAAGCACGTAGAGGATTGCATACAGAGA GCTGAAAATGCCCAACAACATACGAATACGTCAGATGCAGCAGATGACTCCGTAAAAGAA AGCCCTGCCTTTCAAAATAGAATGTTAGTGTACAAGATATCGCCTAATACAACAGATAAT GCAATTAAGGAGTGCCCGATTTGTTTTGAGAATATGGAACCCGGTGAGAAAGTTGGGAGA CTAGAATGCTTGTGTGTTTTCCATTATAAGTGTATTAAGAACTGGTTTCACAAAAGGGCG CAAATGACTGCAGCCCAGAAGGGAAATGGACATGCTTTTGTTAAAAGGAACTTTTGTCCT TTCCATGATGCCGTATTTTAA
Protein Properties
Pfam Domain Function
Protein Residues286
Protein Molecular Weight32675.09961
Protein Theoretical pI5.74
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>E3 ubiquitin-protein ligase PIB1 MVIKEDCINNLARWQADEEAHSCFQCKTNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKK RVHALQKKNSDVESPPYRTCNECYDNLLHLNLLVSSTNRDVRLSQTSVPPNALALSAPDS NTDEDAEILEDSVDQSGTACRSEESSQNEEDHFCPICNSDLTQFPDEEETRKHVEDCIQR AENAQQHTNTSDAADDSVKESPAFQNRMLVYKISPNTTDNAIKECPICFENMEPGEKVGR LECLCVFHYKCIKNWFHKRAQMTAAQKGNGHAFVKRNFCPFHDAVF
References
External Links
ResourceLink
Saccharomyces Genome Database PIB1
Uniprot IDQ06651
Uniprot NamePIB1_YEAST
GenBank Gene IDAY557742
Genebank Protein ID45269375
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Burd, C. G., Emr, S. D. (1998). "Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains." Mol Cell 2:157-162.9702203
  • Shin, M. E., Ogburn, K. D., Varban, O. A., Gilbert, P. M., Burd, C. G. (2001). "FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes." J Biol Chem 276:41388-41393.11526110
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106