Glycosylphosphatidylinositol anchor biosynthesis protein 11 (Q06636)

Identification
NameGlycosylphosphatidylinositol anchor biosynthesis protein 11
Synonyms
  • PIGF homolog
Gene NameGPI11
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionActs in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. Required for the formation of complete GPI precursors CP1 and CP2
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
PE(14:0/16:1(9Z)) + 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol ↔ DG(16:0/16:0/0:0) + 6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol
Metabolites
YMDB IDNameView
GO Classification
Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
organelle membrane
endoplasmic reticulum membrane
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid lipidation
GPI anchor biosynthetic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>660 bp ATGCCAGCTAAAAAAAGGACTAGAAAGACAGTGAAAAAAACCGTATCATTCTCCGATGAC ACAACATTAACAACGCACCAAAATCGTGAGAAAAAGAACGTAGATCATGATCGTCCACCT GTGTATGTGAGGAAAACCCCTCTGATGACATTTCCATACCATTTAGTAGCACTACTTTAT TACTACGTTTTTGTATCTTCAAATTTCAATACGGTGAAGTTGCTAAGTTTTTTGATTCCT ACACAAGTTGCTTATTTAGTTTTACAATTCAATAAATGCACAGTTTACGGTAACAAAATC ATTAAGATCAATTACTCATTGACCATTATTTGTCTAGGTGTTACATTTTTGTTGAGCTTT CCCACAATGTTATTAACTATATTATTTGGTGCGCCATTAATGGACTTATTGTGGGAAACC TGGCTGTTGTCACTGCATTTTGCATTTTTAGCATACCCTGCAGTTTATTCTGTATTTAAT TGTGATTTCAAAGTGGGATTATGGAAGAAGTATTTTATCTTTATCGTTGTAGGGGGTTGG ATTAGTTGTGTTGTCATTCCTTTGGATTGGGATAGAGATTGGCAGAATTGGCCAATTCCT ATTGTTGTTGGAGGTTATTTGGGCGCTTTGGTGGGCTATACTATCGGTGCCTATATATAA
Protein Properties
Pfam Domain Function
Protein Residues219
Protein Molecular Weight25261.80078
Protein Theoretical pI9.72
Signalling Regions
  • None
Transmembrane Regions
  • 46-66
  • 68-88
  • 109-129
  • 136-156
  • 171-191
  • 199-217
Protein Sequence>Glycosylphosphatidylinositol anchor biosynthesis protein 11 MPAKKRTRKTVKKTVSFSDDTTLTTHQNREKKNVDHDRPPVYVRKTPLMTFPYHLVALLY YYVFVSSNFNTVKLLSFLIPTQVAYLVLQFNKCTVYGNKIIKINYSLTIICLGVTFLLSF PTMLLTILFGAPLMDLLWETWLLSLHFAFLAYPAVYSVFNCDFKVGLWKKYFIFIVVGGW ISCVVIPLDWDRDWQNWPIPIVVGGYLGALVGYTIGAYI
References
External Links
ResourceLink
Saccharomyces Genome Database GPI11
Uniprot IDQ06636
Uniprot NameGPI11_YEAST
GenBank Gene IDU28374
Genebank Protein ID849212
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Taron, C. H., Wiedman, J. M., Grimme, S. J., Orlean, P. (2000). "Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose." Mol Biol Cell 11:1611-1630.10793139
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956