Palmitoyltransferase ERF2 (Q06551)

Identification
NamePalmitoyltransferase ERF2
Synonyms
  • DHHC cysteine-rich domain-containing protein ERF2
  • Ras protein acyltransferase
Gene NameERF2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionThe ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
zinc ion binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1080 bp ATGGCCTTGGTCTCTAGAAGGTCGACAAGATCGGAAAGCACCTCAATAACAAAGGAAGAG CATACAGGAGAAGGTTCATTGACGAAGTTGTTCTTCCGATGGCTTGTTACCTTGGAGGGT GATCAGGATATAAACGATGGAAAAGGTTATATATCGTTACCGAATGTCTCGAATTATATA TTCTTCCTTGGTGGCAGGTTCATGACAGTAAAGGGCGCCAAACCGTTGTGGTTAGGTGTT CTCCTTGCTATTGTATGTCCCATGGTTCTCTTCTCCATATTTGAGGCTCACAAATTGTGG CATACCCAAAATGGTTATAAAGTGCTGGTCATTTTCTTCTATTATTTTTGGGTCATAACG CTAGCATCCTTTATCAGAACAGCCACTAGTGATCCTGGCGTTCTTCCGAGAAATATTCAT TTAAGTCAACTAAGAAATAATTATCAGATCCCGCAAGAATATTACAACTTGATAACACTA CCAACACATTCTTCAATTTCAAAAGACATTACTATCAAGTATTGTCCATCATGTAGGATA TGGAGACCACCTCGGTCTTCTCACTGTTCCACATGTAACGTCTGCGTAATGGTTCATGAC CACCATTGCATATGGGTCAATAATTGCATAGGAAAAAGGAACTACCGGTTCTTTTTAATA TTCCTGTTAGGTGCAATACTTTCGTCCGTCATATTATTAACTAATTGTGCCATCCATATT GCACGGGAATCAGGGGGGCCTCGCGATTGTCCCGTTGCAATATTGTTACTTTGCTATGCA GGGCTAACCTTATGGTATCCGGCAATACTGTTTACTTATCACATATTTATGGCAGGTAAT CAGCAAACAACAAGGGAATTTTTGAAAGGTATTGGATCGAAAAAAAACCCTGTATTCCAT CGTGTGGTCAAGGAGGAAAACATATATAATAAGGGGTCCTTTTTGAAAAATATGGGTCAC TTGATGTTAGAACCAAGGGGCCCAAGCTTTGTAAGTGCCAGAAAGCCACATGAAGCTGGA GATTGGAGATTTATGGATTTATCGCCAGCACACAGCTTTGAAAAAATACAGAAAATATAA
Protein Properties
Pfam Domain Function
Protein Residues359
Protein Molecular Weight41098.60156
Protein Theoretical pI9.73
Signalling Regions
  • None
Transmembrane Regions
  • 76-96
  • 105-125
  • 218-238
  • 251-271
Protein Sequence>Palmitoyltransferase ERF2 MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYI FFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVIT LASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRI WRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHI ARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFH RVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI
References
External Links
ResourceLink
Saccharomyces Genome Database ERF2
Uniprot IDQ06551
Uniprot NameERFB_YEAST
GenBank Gene IDAY692913
Genebank Protein ID51013277
General Reference
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Bartels, D. J., Mitchell, D. A., Dong, X., Deschenes, R. J. (1999). "Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae." Mol Cell Biol 19:6775-6787.10490616
  • Lobo, S., Greentree, W. K., Linder, M. E., Deschenes, R. J. (2002). "Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae." J Biol Chem 277:41268-41273.12193598
  • Zhao, L., Lobo, S., Dong, X., Ault, A. D., Deschenes, R. J. (2002). "Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins." J Biol Chem 277:49352-49359.12379641
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258