Target of rapamycin complex 2 subunit AVO2 (Q04749)

Identification
NameTarget of rapamycin complex 2 subunit AVO2
Synonyms
  • TORC2 subunit AVO2
  • Adheres voraciously to TOR2 protein 2
Gene NameAVO2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionComponent of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway
Cellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1281 bp ATGTTGAAAGAGCCCTCAGTTCGCTTGCGGGAGGCTATTATTGAAGGCAATTTACTTATA GTGAAAAGATTATTGCGACGGAATCCGGATTTGCTAACCAACATAGACTCAGAGAACGGA TGGAGTTCATTACATTACGCCTCATACCATGGAAGATACCTTATATGCGTGTATTTAATT CAGCTGGGGCACGACAAGCATGAACTAATAAAAACCTTTAAAGGAAACACCTGTGTGCAT TTAGCATTAATGAAAGGGCACGAGCAAACCTTACATTTACTTTTGCAACAATTTCCGCGA TTTATCAACCATCGCGGAGAGAATGGTAGAGCCCCCATCCATATAGCATGTATGAACGAT TACTACCAATGTCTGAGTCTGTTGATAGGAGTTGGTGCTGATTTATGGGTAATGGACACT AATGGCGACACGCCGCTGCATGTATGCCTGGAGTATGGCAGTATAAGTTGTATGAAGATG CTTCTCAATGAAGGTGAGGTGTCCTTGGATGATAATGTCAGGGACAAGGGAAATTGGAAG CCAATAGATGTAGCACAAACGTTTGAAGTAGGTAATATATATTCAAAAGTGTTAAAAGAG GTGAAAAAGAAGGGGCCACCGTTGGGTGCAGGCAAAAAACCAAGTTCATTCAGAACTCCT ATACTAAATGCGAAGGCCACTTTCGAGGACGGGCCTTCCCCAGTTTTAAGCATGAATTCG CCATATTCGCTCTATTCCAATAATAGTCCGTTGCCGGTATTACCAAGAAGGATATCAACG CATACAACAAGCGGTAACGGTGGGAATCGGAGGAGTTCTATCACAAATCCAGTATTCAAC CCACGAAAACCAACCTTGTCTACGGACAGTTTTTCGTCAAGCTCAAATTCCAGCTCGAGA CTAAGAGTGAACTCCATCAACGTCAAGACTCCAGTAGGTGTGTCGCCCAAGAAAGAGCTT GTATCTGAATCAGTACGACACAGTGCAACACCAACAAGTCCGCACAACAACATCGCGTTG ATTAATAGATACTTGTTGCCTAACAAGAGCAATGACAACGTGAGAGGAGACTCACAGACA GCTACAATCAACGATGACGGTGGCGGCGGCAATGGCGGTGATGCCACTATAGGAATGGGA CTAAGAAAGGACCCGGACGATGAGAACGAGAACAAGTACAAGATTAAGGTAAACAATGGC GAGCCGAGGAGACGAGTGTCACTTCTGAACATACCCATCTCAAAATTAAGAAATAGCAAT AACACGCGTGCAGAAGATTGA
Protein Properties
Pfam Domain Function
Protein Residues426
Protein Molecular Weight47139.10156
Protein Theoretical pI9.79
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Target of rapamycin complex 2 subunit AVO2 MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLI QLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMND YYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWK PIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNS PYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSR LRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQT ATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSN NTRAED
References
External Links
ResourceLink
Saccharomyces Genome Database AVO2
Uniprot IDQ04749
Uniprot NameAVO2_YEAST
GenBank Gene IDZ48952
Genebank Protein ID763015
General Reference
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., Hall, M. N. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control." Mol Cell 10:457-468.12408816
  • Wedaman, K. P., Reinke, A., Anderson, S., Yates, J. 3rd, McCaffery, J. M., Powers, T. (2003). "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae." Mol Biol Cell 14:1204-1220.12631735
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Fadri, M., Daquinag, A., Wang, S., Xue, T., Kunz, J. (2005). "The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2." Mol Biol Cell 16:1883-1900.15689497
  • Wullschleger, S., Loewith, R., Oppliger, W., Hall, M. N. (2005). "Molecular organization of target of rapamycin complex 2." J Biol Chem 280:30697-30704.16002396
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956