Type 2A phosphatase-associated protein 42 (Q04372)

Identification
NameType 2A phosphatase-associated protein 42
SynonymsNot Available
Gene NameTAP42
Enzyme ClassNot Available
Biological Properties
General FunctionTOR signaling
Specific FunctionInvolved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.
Cellular LocationNot Available
SMPDB Pathways
TOR signalling pathway: Rapamycin based repressionPW002514 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
cytosol
negative regulation of signal transduction
TOR signaling
extrinsic component of membrane
protein phosphatase 2A binding
protein phosphatase type 2A regulator activity
positive regulation of transcription from RNA polymerase I promoter
regulation of dephosphorylation
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1101 bp ATGGCGTCAGTAACAGAACAATTCAACGATATTATTAGCTTATACTCAACAAAATTGGAA CACACATCTTTGAGGCAAGATTCACCAGAGTACCAGGGATTATTACTTTCCACGATCAAG AAATTATTAAACTTAAAAACAGCAATTTTTGACAGGTTGGCATTGTTCAGTACTAATGAG ACCATTGATGATGTGTCTACTGCTTCCATCAAATTTCTAGCAGTTGATTACTATTTAGGA TTATTGATATCAAGACGACAGTCGAATGATTCGGATGTTGCTCAAAGGCAGTCTATGAAA TTGATTTACCTGAAAAAAAGCGTTGAATCTTTCATTAATTTCCTGACACTATTGCAGGAT TATAAGCTTCTAGATCCTTTGGTTGGTGAAAAACTAGGTAACTTCAAGGATCGTTATAAC CCTCAGCTTAGCGAATTGTACGCGCAACCAAAAAATAACAAAGATTTATCTGGAGCACAG TTGAAGAGAAAAGAAAAGATTGAGCTATTCCAGCGCAATAAAGAAATTAGCACAAAACTG CACTGCTTGGAGTTGGAATTAAAAAACAACGACGAGGACCACGACCATGATGAATTACTA AGAGAACTATATTTGATGAGGTTACATCACTTTAGTCTTGATACGATTAACAACATTGAA CAGAATTTATTTGAATGTGAAATGCTCTCTAATTTCCTCAAAAATTCCGTACATGAAGTC AAATCATCAGGTACTCAGATACGAAAAGAATCGAATGATGATGATTCCACTGGTTTTACC GATAAATTAGAGAATATAAATAAGCCATTGATAGACAAAAAAGGTCAAGTCTTGAGGAAC TTCACGCTTGTCGACAAAAGGCAACAACTGCAACAAAAAGTGCGAGGATATGGTCAATAT GGACCAACAATGTCGGTGGAGGAATTTTTAGATAAAGAGTTTGAAGAAGGTCGCGTTCTT CAAGGTGGCGAAGAACCAGAGCAAGCACCAGATGAAGAAAACATGGACTGGCAAGATAGA GAAACCTATAAAGCTCGTGAGTGGGACGAGTTCAAGGAAAGTCATGCTAAGGGAAGCGGA AATACCATGAATAGAGGATAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues366
Protein Molecular Weight42567.465
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Type 2A phosphatase-associated protein 42 MASVTEQFNDIISLYSTKLEHTSLRQDSPEYQGLLLSTIKKLLNLKTAIFDRLALFSTNE TIDDVSTASIKFLAVDYYLGLLISRRQSNDSDVAQRQSMKLIYLKKSVESFINFLTLLQD YKLLDPLVGEKLGNFKDRYNPQLSELYAQPKNNKDLSGAQLKRKEKIELFQRNKEISTKL HCLELELKNNDEDHDHDELLRELYLMRLHHFSLDTINNIEQNLFECEMLSNFLKNSVHEV KSSGTQIRKESNDDDSTGFTDKLENINKPLIDKKGQVLRNFTLVDKRQQLQQKVRGYGQY GPTMSVEEFLDKEFEEGRVLQGGEEPEQAPDEENMDWQDRETYKAREWDEFKESHAKGSG NTMNRG
References
External Links
ResourceLink
Saccharomyces Genome Database TAP42
Uniprot IDQ04372
Uniprot NameTAP42
PDB ID
2V0P
General ReferenceNot Available