| Identification |
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| Name | Serine/threonine-protein kinase STE20 |
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| Synonyms | Not Available |
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| Gene Name | STE20 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | vacuole inheritance |
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| Specific Function | MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling. |
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| Cellular Location | Not Available |
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| SMPDB Pathways | | Stress-activated signalling pathways: high osmolarity 1469654356 | PW002970 |    | | Stress-activated signalling pathways: high osmolarity test 1 | PW002773 |    | | Stress-activated signalling pathways: pheromone stress test 1 | PW012843 |    | | Stress-activated signalling pathways: starvation test 1 | PW003483 |    |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | |
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| GO Classification | | Function |
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| identical protein binding | | budding cell apical bud growth | | vacuole inheritance | | bipolar cellular bud site selection | | osmosensory signaling pathway via Sho1 osmosensor | | ATP binding | | negative regulation of gene expression | | pheromone-dependent signal transduction involved in conjugation with cellular fusion | | negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter | | nucleus | | sterol import | | cytoplasm | | histone kinase activity (H2B-S14 specific) | | incipient cellular bud site | | MAP kinase kinase kinase kinase activity | | mating projection tip | | activation of MAPKKK activity | | invasive growth in response to glucose limitation | | positive regulation of apoptotic process | | protein phosphorylation | | stress granule assembly | | pseudohyphal growth | | signal transduction involved in filamentous growth | | cellular response to heat | | regulation of exit from mitosis |
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >2820 bp
ATGAGCAATGATCCATCTGCTGTATCGGAACTACCAGACAAGGACAGTCTTGATAACGGT
ATCAGCAATGACAATGAAAGGGCCATGGGCGGCAATGGCGATGGCGGCGATGGATTACGA
TTACCAAGGACCACTGGAACTTTGAACGTCAATGCCTTACAAAAAGGCACTAATGCTGCC
CATGAAGCTGGTGGATACAAATCCATGGATCCTGCGAAGAACGCGGAGACAACCAATGAT
GATGACAATAATGTCGTTTCACTAGATGATCCTATTCAATTTACCCGAGTATCTTCCTCC
TCTGTCATCAGTGGAATGTCTTCATCCATGAGTCCTCATTCTAACATCGATGAAACCAAA
TCTCTAGAAGCAGTCACTCCAAACATAAATACCAGCAATATAACCCCGGATCATTCTGCT
GACAACACATTTTCTACCATAAATGCGTCCGAGTCAGATCACCAGTTTAATGACACTTTA
CTATCAAAACTGTCGTTAACAGATTCTACAGAAACTATAGAAAATAACGCGACAGTGAAG
CACCAGCAGCCAGTTGCATCTTCCACAGTAAACTCGAATAAGAGCTCCACTGATATACGA
AGGGCTACACCAGTGTCCACTCCCGTTATCTCTAAACCATCGATGACAACCACGCCAAGA
CAGATCAATTCAGCTTCCCATTCGCTTTCGAACCCTAAGCATAAGCAACATAAACCAAAA
GTTAAACCGTCCAAGCCTGAAGCAAAAAGTAAACCGGTTTCTGTGAAAAAAAGCTTTCCT
TCGAAAAATCCTTTAAAAAACTCCTCTCCACCTAAAAAGCAAACAGAAAAATCGTATTAT
TCTTCCTCTTCGAAAAAAAGGAAAAGCGGTTCAAATAGTGGTACACTAAGAATGAAAGAT
GTCTTTACGTCCTTTGTACAGAATATAAAGAGAAATTCTCAGGATGATAAAAGGGCCTCA
TCGTCGTCCAATAATTCTTCCTCATCTTCTATAACCACCGCTTTGAGGATATCTACGCCA
TACAATGCCAAGCATATCCACCATGTGGGCGTGGACTCCAAGACTGGTGAGTACACAGGT
TTGCCGGAGGAATGGGAAAAATTGTTGACTTCTAGTGGTATTTCCAAAAGAGAACAACAG
CAAAACATGCAAGCAGTCATGGATATTGTCAAATTCTATCAGGATGTCACGGAAACAAAC
GGTGAAGATAAAATGTTCAAGACTTTCAACACAACCACAGGATTGCCGGGAAGTCCTCAA
GTTTCAACACCGCCTGCAAACTCATTCAATAAATTTCCTCCGTCGACAAGTGATTCGCAC
AATTACGGTTCCAGAACAGGTACACCAATGTCCAATCACGTCATGTCTCCAACCTTAAAT
ACAGATTCTAGTTCAGCAAACGGGAAATTCATACCAAGTAGACCGGCTCCTAAGCCCCCA
TCTTCTGCGTCCGCTTCAGCTCCAATTATAAAATCACCCGTCATGAATTCTGCCGCCAAT
GTTTCGCCCTTGAAGCAGACTCATGCACCTACAACTCCGAACAGGACCAGCCCAAACAGG
TCCTCAATATCAAGAAATGCCACTTTAAAAAAAGAGGAGCAGCCACTACCACCAATACCT
CCAACCAAATCCAAAACGTCTCCAATCATCTCCACAGCTCACACACCACAGCAAGTTGCT
CAATCGCCAAAAGCGCCGGCGCAAGAGACGGTAACGACACCTACTTCGAAGCCAGCTCAA
GCAAGAAGCTTGTCTAAAGAATTAAATGAGAAAAAGAGAGAGGAAAGGGAAAGACGTAAA
AAACAACTATATGCCAAATTGAACGAAATTTGCTCAGACGGTGACCCAAGTACAAAATAT
GCCAATTTAGTAAAAATTGGTCAAGGTGCATCAGGTGGTGTTTATACTGCTTATGAAATA
GGTACGAATGTCTCAGTGGCCATTAAGCAAATGAATCTCGAAAAGCAACCAAAAAAGGAG
CTAATCATCAATGAGATTCTGGTCATGAAGGGTAGCAAACACCCTAATATAGTTAATTTC
ATTGATTCTTACGTTTTAAAAGGCGACCTTTGGGTCATTATGGAATACATGGAAGGTGGC
TCCTTAACTGATGTGGTCACCCATTGTATTTTGACAGAAGGTCAAATTGGTGCCGTTTGT
AGAGAAACTTTGAGTGGGTTGGAATTTTTACATTCTAAAGGTGTTCTTCACAGAGATATC
AAATCCGATAACATCCTATTGTCCATGGAAGGGGATATTAAGTTAACGGATTTCGGTTTT
TGCGCTCAAATCAATGAATTGAACTTGAAAAGAACTACTATGGTGGGAACGCCTTATTGG
ATGGCGCCTGAAGTGGTTTCTAGGAAAGAATATGGCCCAAAAGTAGATATCTGGTCGTTG
GGTATCATGATCATTGAAATGATCGAGGGGGAGCCTCCATATTTAAATGAAACCCCGCTA
AGAGCACTGTATTTAATTGCTACAAATGGTACACCCAAGTTAAAGGAACCCGAGAATCTA
TCGTCAAGCTTGAAAAAATTCCTTGATTGGTGTTTATGTGTGGAGCCCGAAGATAGAGCA
AGCGCTACGGAATTGCTTCATGATGAATATATCACGGAGATAGCTGAAGCCAATTCCTCA
TTGGCCCCGCTAGTCAAGTTAGCAAGATTGAAGAAAGTAGCTGAGAACATGGATGCTGAT
GAAGATAATGACGACGATAACGACAACGAGCATATTAATAAGACAAACAATTGTGACGAC
AATAACGATAGCAAAGAAACCGTAAATTTGGACGTAACTGAAGATGATAAACAAAAGTAA
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| Protein Properties |
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| Pfam Domain Function | Not Available |
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| Protein Residues | 939 |
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| Protein Molecular Weight | 102361.32 |
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| Protein Theoretical pI | Not Available |
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| PDB File | show |
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| Signalling Regions | Not Available |
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| Transmembrane Regions | Not Available |
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| Protein Sequence | >Serine/threonine-protein kinase STE20
MSNDPSAVSELPDKDSLDNGISNDNERAMGGNGDGGDGLRLPRTTGTLNVNALQKGTNAA
HEAGGYKSMDPAKNAETTNDDDNNVVSLDDPIQFTRVSSSSVISGMSSSMSPHSNIDETK
SLEAVTPNINTSNITPDHSADNTFSTINASESDHQFNDTLLSKLSLTDSTETIENNATVK
HQQPVASSTVNSNKSSTDIRRATPVSTPVISKPSMTTTPRQINSASHSLSNPKHKQHKPK
VKPSKPEAKSKPVSVKKSFPSKNPLKNSSPPKKQTEKSYYSSSSKKRKSGSNSGTLRMKD
VFTSFVQNIKRNSQDDKRASSSSNNSSSSSITTALRISTPYNAKHIHHVGVDSKTGEYTG
LPEEWEKLLTSSGISKREQQQNMQAVMDIVKFYQDVTETNGEDKMFKTFNTTTGLPGSPQ
VSTPPANSFNKFPPSTSDSHNYGSRTGTPMSNHVMSPTLNTDSSSANGKFIPSRPAPKPP
SSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNATLKKEEQPLPPIP
PTKSKTSPIISTAHTPQQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREERERRK
KQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKE
LIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVC
RETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYW
MAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENL
SSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVKLARLKKVAENMDAD
EDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTEDDKQK |
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| References |
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| External Links | |
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| General Reference | Not Available |
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