Down-regulator of invasive growth 1 (Q03063)

Identification
NameDown-regulator of invasive growth 1
Synonyms
  • Regulator of STE12 protein 1
  • Regulator of sterile twelve 1
Gene NameDIG1
Enzyme ClassNot Available
Biological Properties
General Functionnegative regulation of transcription from RNA polymerase II promoter by pheromones
Specific FunctionDIG1 and DIG2 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG1 colocalizes to promoters with STE12 and redistributes with it during induction of filamentation (by butanol) or mating (by pheromone) to program specific genes, but binding of DIG1 to STE12 is reduced by pheromone treatment.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
nucleus
Ste12p-Dig1p-Dig2p complex
Tec1p-Ste12p-Dig1p complex
negative regulation of transcription from RNA polymerase II promoter by pheromones
transcription factor binding
negative regulation of invasive growth in response to glucose limitation
negative regulation of phenotypic switching
negative regulation of pseudohyphal growth
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1359 bp ATGGCCGTATCAGCCCGTTTGAGAACGACTGCCGAGGATACATCCATTGCTAAATCAACA CAAGATCCAATTGGTGATACAGAAATCAGTGTAGCAAATGCTAAGGGCAGCAGCGATAGC AACATTAAGAATTCGCCAGGCGGAAACAGCGTTGGTCAGGAGTCGGAGCTAGAGCATGTC CCTGAGGAGGATGACTCTGGTGACAAGGAAGCAGATCATGAGGATTCTGAGACAGCCACT GCGAAGAAGAGGAAAGCCCAACCATTGAAGAATCCGAAGAAATCATTGAAGAGGGGCAGA GTCCCGGCGCCTTTGAATTTATCGGATAGCAACACTAATACACACGGTGGTAATATTAAG GACGGCAACTTGGCTTCGTCTAACTCTGCACATTTTCCTCCTGTTGCTAATCAAAACGTG AAAAGCGCGCCCGCACAAGTTACTCAGCATTCCAAGTTCCAGCCCCGTGTCCAATACTTG GGAAAGGCCAGTTCTAGACAATCTATACAAGTGAATAATAGCAGCAATAGTTATGGGAAA CCACACATGCCCTCGGCGGGCATCATGAGCGCCATGAACCCTTACATGCCCATGAATCGC TACATAATGTCACCATATTATAATCCGTACGGTATCCCTCCACCTCACATGCTGAACAAG CCCATAATGACACCCTACGTGTCGTATCCATATCCAATGGGACCGCGGACCTCCATTCCT TATGCTATGCAAGGTGGCAACGCTAGGCCCTACGAAGAAAATGAGTATAGTGCTAGCAAT TACAGAAACAAGAGGGTTAACGACTCATATGATTCGCCTTTGAGTGGCACCGCTTCCACT GGGAAAACCAGACGATCCGAGGAAGGCTCAAGAAATTCTAGCGTAGGATCAAGTGCGAAT GCCGGTCCTACGCAACAGCGCGCGGATCTACGCCCAGCAGATATGATACCTGCTGAAGAA TACCACTTTGAACGGGATGCATTACTCTCGGCCAACACGAAAGCCAGAAGCGCAAGCACA AGCACAAGTACAAGCACAAGCACAAACCGGGACAGGAGTTCATGGCATGAGGCAGAACCC AATAAAGACGAAGAAGAGGGTACGGACTTGGCCATCGAGGACGGAGCGGTCCCCACTCCC ACTTTTACTACGTTCCAGCGGACCTCGCAGCCGCAGCAGCAATCACCTAGTCTTCTTCAA GGCGAAATCCGACTCTCATCGCATATTTTTGCCTTCGAGTTCCCCCTGAGCTCTAGCAAT GTAGACAAGAAAATGTTTATGAGCATATGTAATAAAGTATGGAATGAATCAAAGGAGCTG ACAAAAAAATCATCATCACATCACAGAACCGGAAAATAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues452
Protein Molecular Weight49355.795
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Down-regulator of invasive growth 1 MAVSARLRTTAEDTSIAKSTQDPIGDTEISVANAKGSSDSNIKNSPGGNSVGQESELEHV PEEDDSGDKEADHEDSETATAKKRKAQPLKNPKKSLKRGRVPAPLNLSDSNTNTHGGNIK DGNLASSNSAHFPPVANQNVKSAPAQVTQHSKFQPRVQYLGKASSRQSIQVNNSSNSYGK PHMPSAGIMSAMNPYMPMNRYIMSPYYNPYGIPPPHMLNKPIMTPYVSYPYPMGPRTSIP YAMQGGNARPYEENEYSASNYRNKRVNDSYDSPLSGTASTGKTRRSEEGSRNSSVGSSAN AGPTQQRADLRPADMIPAEEYHFERDALLSANTKARSASTSTSTSTSTNRDRSSWHEAEP NKDEEEGTDLAIEDGAVPTPTFTTFQRTSQPQQQSPSLLQGEIRLSSHIFAFEFPLSSSN VDKKMFMSICNKVWNESKELTKKSSSHHRTGK
References
External Links
ResourceLink
Saccharomyces Genome Database DIG1
Uniprot IDQ03063
Uniprot NameDIG1
General ReferenceNot Available