Identification |
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Name | Protein MLP1 |
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Synonyms | |
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Gene Name | MLP1 |
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Enzyme Class | Not Available |
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Biological Properties |
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General Function | transcriptional activation by promoter-terminator looping |
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Specific Function | Involved together with the closely related MLP2 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP1 also recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself. |
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Cellular Location | Not Available |
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SMPDB Pathways | Stress-activated signalling pathways: cell wall stress test 1 | PW007861 | |
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KEGG Pathways | Not Available |
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SMPDB Reactions | Not Available |
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KEGG Reactions | Not Available |
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Metabolites | |
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GO Classification | Function |
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ribonucleoprotein complex binding | mitotic spindle assembly checkpoint | negative regulation of protein import into nucleus during spindle assembly checkpoint | nuclear retention of unspliced pre-mRNA at the site of transcription | poly(A)+ mRNA export from nucleus | protein import into nucleus | protein localization to nuclear pore | telomere tethering at nuclear periphery | transcriptional activation by promoter-terminator looping | nucleoplasm | DNA repair | nuclear envelope | nuclear pore nuclear basket | nucleocytoplasmic transporter activity |
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Gene Properties |
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Chromosome Location | Not Available |
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Locus | |
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Gene Sequence | >5628 bp
ATGTCGGATCATGATACTCCAATGGAAAGCATACAAAATGGTGAAAATTCAGACGAAAGA
TTGAACGCCATTGCGTCTTTTTTCGGTTGCTCTTTAGAGCAGGTTAAATCATTTGACGGT
GATGTGGTAAAACACCTTAACGATAAACTTTTACAGTTTAATGAACTTAAATCGGAGAAT
CTAAAGGTTACCGTCTCATTCGATGAATTGAAGGCTAGTTCTTTAAAGAAAATTGATGGT
TTGAAGACAGAAATGGAAAACGTTATAAGAGAAAATGATAAAATCCGAAAAGAGAGGAAT
GATACTTTTGTTAAGTTCGAATCTGTAGAAAATGAAAAGATGAAATTATCAAGTGAGCTA
GAGTTTGTGAAAAGGAAGCTCGATGATTTAACTGAGGAGAAAAAGGAAACCCAGAGTAAT
CAACAGCGAACCCTGAAAATACTGGATGAAAGACTAAAAGAAATAGAATTGGTCAGGGTT
GAGAATAATCGCTCCAATAGTGAATGTAAGAAACTACGCTCTACAATAATGGATTTAGAA
ACAAAACAACAGGGCTATATTACTAATGACCTGAATTCTAGAACTGAACTGGAAAGAAAA
ACACAAGAATTGACTTTATTGCAGTCAAATAATGATTGGCTAGAAAAGGAGCTACGTTCA
AAAAATGAACAGTATCTCTCCTACAGACAAAAAACCGACAAAGTAATTCTAGATATCAGG
AATGAATTAAATCGTTTAAGGAATGATTTTCAAATGGAAAGAACGAATAATGATGTTTTG
AAGCAAAAAAATAACGAATTGTCAAAATCTTTACAAGAAAAACTACTGGAAATCAAGGGT
CTATCCGACTCCCTAAATTCCGAAAAGCAAGAATTTTCTGCAGAAATGTCCCTAAAGCAA
CGTTTAGTGGACCTTTTAGAATCACAATTGAACGCTGTAAAAGAAGAATTGAACAGTATA
AGAGAGTTGAACACTGCAAAGGTAATAGCAGATGATTCAAAAAAACAAACTCCCGAAAAT
GAAGACTTACTTAAGGAATTGCAGTTAACGAAAGAAAAATTAGCACAATGCGAAAAAGAA
TGTCTACGTTTATCCTCTATAACTGACGAAGCAGATGAAGATAATGAAAATTTATCTGCA
AAATCTAGTTCTGATTTTATATTCCTGAAGAAACAATTAATTAAAGAAAGGCGTACCAAG
GAACATCTTCAAAATCAAATTGAAACATTCATCGTAGAGTTGGAACATAAAGTGCCCATT
ATAAACTCTTTCAAAGAAAGAACTGACATGTTGGAAAACGAATTGAATAACGCTGCATTG
TTACTAGAGCATACATCGAACGAGAAGAATGCAAAGGTTAAGGAATTAAATGCCAAAAAC
CAAAAGCTAGTGGAATGTGAAAATGATCTTCAAACTTTAACTAAACAACGTCTCGATCTA
TGCCGTCAAATACAATACCTTTTAATTACCAATTCTGTTTCTAATGACTCGAAGGGACCC
TTACGTAAGGAAGAAATTCAATTTATTCAAAACATTATGCAGGAAGACGATAGTACTATC
ACAGAATCTGACTCTCAAAAAGTCGTAACTGAAAGACTAGTTGAATTCAAAAACATTATT
CAATTACAAGAAAAAAATGCAGAACTTTTGAAAGTAGTAAGAAACTTAGCCGATAAGTTG
GAATCGAAAGAAAAGAAATCTAAACAAAGTCTTCAGAAAATCGAAAGTGAAACAGTAAAT
GAGGCTAAAGAGGCTATAATAACTTTAAAGAGTGAAAAAATGGATCTAGAATCAAGAATT
GAGGAACTACAGAAAGAGCTTGAAGAATTGAAAACTTCTGTTCCCAACGAAGATGCGTCA
TACAGCAATGTAACTATAAAACAGTTAACCGAAACTAAGAGAGACCTCGAATCTCAAGTA
CAAGACTTGCAAACTCGTATCTCGCAAATTACTAGGGAGTCTACTGAAAATATGTCACTT
TTAAACAAGGAGATACAGGACCTGTATGACAGCAAGAGCGACATATCCATTAAGCTTGGA
AAGGAAAAATCATCGAGAATATTGGCAGAGGAACGATTTAAACTACTTTCGAATACGTTA
GATCTAACTAAAGCTGAGAACGACCAACTGCGCAAAAGGTTTGATTATTTACAGAATACT
ATTTTAAAACAAGATTCCAAAACACACGAGACACTTAATGAATACGTTTCCTGTAAATCT
AAGTTAAGCATTGTTGAAACAGAATTATTGAACCTGAAAGAAGAACAGAAATTAAGAGTT
CATTTAGAAAAGAACTTGAAACAAGAACTGAATAAACTCTCCCCTGAAAAGGACAGTTTA
CGCATCATGGTAACTCAATTACAAACTTTACAAAAGGAGCGTGAAGATCTATTGGAAGAG
ACTAGGAAATCATGTCAAAAGAAAATAGATGAACTTGAAGATGCTCTCAGCGAACTTAAA
AAGGAAACTTCTCAAAAAGACCATCATATCAAACAGCTGGAAGAAGACAACAATTCAAAT
ATAGAATGGTACCAAAATAAAATCGAAGCTTTGAAGAAAGATTATGAATCAGTAATAACT
TCTGTAGATAGTAAGCAAACTGACATTGAGAAATTACAATATAAAGTCAAATCACTAGAA
AAGGAAATCGAGGAGGACAAGATTCGTTTACATACTTATAATGTTATGGATGAAACAATT
AACGATGATTCCCTACGCAAGGAGTTGGAAAAATCCAAGATTAACTTAACTGATGCTTAT
TCACAAATCAAAGAATACAAGGATCTCTACGAGACTACCTCTCAGTCTTTGCAGCAAACG
AATTCTAAATTGGATGAATCTTTCAAGGACTTTACTAACCAGATTAAAAACCTAACTGAT
GAAAAAACTAGTTTGGAGGATAAGATTTCGCTTCTAAAAGAGCAAATGTTTAATTTGAAT
AATGAGCTAGATTTGCAGAAAAAAGGGATGGAAAAAGAAAAAGCTGACTTTAAGAAAAGG
ATATCAATTTTACAGAACAATAATAAAGAAGTCGAAGCTGTTAAGTCCGAATATGAATCG
AAGTTATCAAAAATCCAAAACGACCTTGATCAACAAACTATATATGCTAATACTGCGCAA
AACAACTATGAACAAGAACTACAGAAACATGCAGATGTTTCTAAGACGATTAGTGAATTA
AGAGAGCAATTACATACGTACAAAGGTCAAGTTAAGACCCTGAACTTATCGCGTGATCAA
CTGGAGAATGCTCTGAAAGAAAACGAAAAGAGTTGGTCCTCCCAGAAGGAATCTTTATTA
GAACAGCTAGATTTATCGAATTCTCGTATTGAGGATTTATCCTCCCAAAATAAACTATTG
TATGATCAAATACAAATCTACACAGCTGCGGACAAAGAAGTCAATAATTCGACAAACGGA
CCTGGTTTGAATAATATTTTAATTACACTACGTCGCGAAAGGGATATTCTTGATACAAAA
GTGACGGTGGCTGAAAGAGATGCAAAAATGTTGAGACAAAAAATTTCTTTGATGGATGTT
GAATTACAAGATGCTCGTACTAAGCTAGATAATTCAAGAGTTGAAAAGGAAAATCATTCT
TCCATTATTCAACAGCATGACGACATTATGGAGAAATTAAATCAATTAAATCTATTAAGA
GAAAGTAACATAACATTGCGGAATGAGCTGGAAAACAACAATAACAAGAAGAAGGAACTG
CAATCTGAATTAGATAAATTGAAGCAAAATGTTGCGCCTATCGAGTCCGAATTGACAGCC
TTGAAATATTCTATGCAAGAAAAAGAGCAAGAGCTCAAATTAGCTAAAGAAGAGGTTCAT
CGTTGGAAAAAGCGCTCACAAGACATATTGGAGAAACATGAACAATTGAGCTCAAGCGAT
TATGAGAAGCTAGAAAGCGAGATAGAAAATTTGAAGGAGGAACTAGAAAATAAGGAGCGT
CAAGGAGCGGAAGCCGAGGAAAAATTTAACAGGCTGAGAAGACAAGCGCAAGAGAGATTA
AAAACATCAAAACTCTCACAGGACTCATTGACTGAACAAGTAAATAGTCTAAGGGATGCA
AAGAACGTGTTGGAAAATTCCTTGAGTGAGGCAAACGCGAGAATCGAAGAGTTACAAAAT
GCAAAAGTAGCACAAGGTAACAACCAGTTAGAAGCAATAAGAAAATTACAAGAAGACGCA
GAAAAGGCTTCAAGAGAGCTTCAAGCCAAGTTAGAAGAAAGTACGACTTCTTACGAATCT
ACGATAAACGGCTTAAATGAAGAGATTACAACATTAAAAGAAGAAATTGAAAAACAAAGG
CAAATCCAGCAACAGTTACAAGCTACATCTGCAAATGAACAAAATGACTTATCTAACATA
GTTGAGTCTATGAAAAAGTCTTTTGAAGAAGATAAAATCAAATTCATCAAAGAAAAAACC
CAAGAAGTTAATGAAAAAATACTCGAGGCCCAAGAAAGGCTAAATCAACCTTCCAATATC
AATATGGAGGAGATTAAAAAAAAATGGGAATCTGAGCACGAACAGGAAGTATCTCAAAAG
ATTCGCGAAGCTGAGGAAGCCCTCAAAAAGCGAATCAGATTACCCACTGAGGAGAAAATT
AATAAGATAATCGAACGAAAGAAGGAGGAATTGGAAAAAGAGTTTGAAGAAAAGGTTGAG
GAGAGAATAAAATCAATGGAACAATCTGGAGAAATAGACGTGGTGCTTCGAAAACAGCTA
GAAGCTAAGGTTCAAGAGAAACAAAAGGAATTGGAAAACGAGTATAACAAAAAATTACAA
GAAGAACTCAAAGATGTACCACACTCAAGTCATATCTCAGATGATGAAAGGGACAAATTA
CGAGCAGAAATCGAAAGCAGGTTGAGGGAGGAGTTCAACAATGAACTGCAAGCCATAAAG
AAGAAATCCTTCGACGAAGGAAAGCAACAAGCAATGATGAAAACTACCCTTTTGGAAAGA
AAACTTGCCAAGATGGAATCTCAATTGTCAGAAACAAAACAAAGTGCCGAGAGTCCTCCG
AAATCTGTTAACAATGTACAAAATCCATTACTAGGATTACCTAGGAAAATCGAAGAGAAT
TCAAATTCACCATTCAATCCGTTACTTTCCGGTGAAAAACTCTTAAAGCTAAATTCTAAG
TCTTCATCAGGTGGATTTAACCCTTTTACCTCGCCATCCCCAAATAAGCACTTACAAAAT
GATAATGACAAAAGGGAGTCGTTGGCTAACAAGACAGATCCACCAACTCATTTGGAACCC
AGCTTCAACATTCCCGCCTCAAGGGGTCTAATATCTTCATCTTCCACTTTGTCAACTGAT
ACAAATGATGAAGAACTTACTAGCAACAATCCTGCCCAAAAGGATTCATCGAACAGAAAT
GTTCAATCGGAAGAGGATACAGAAAAAAAGAAAGAGGGAGAACCTGTTAAAAGAGGAGAG
GCAATAGAAGAGCAGACGAAATCCAACAAGCGACCTATTGATGAGGTAGGAGAGCTGAAA
AATGATGAAGACGACACTACAGAAAACATTAATGAGTCAAAAAAGATCAAGACTGAAGAT
GAGGAAGAAAAAGAAACCGATAAGGTGAATGACGAGAACAGTATATAA |
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Protein Properties |
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Pfam Domain Function | Not Available |
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Protein Residues | 1875 |
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Protein Molecular Weight | 218454.4 |
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Protein Theoretical pI | Not Available |
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Signalling Regions | Not Available |
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Transmembrane Regions | Not Available |
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Protein Sequence | >Protein MLP1
MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSEN
LKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSEL
EFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLE
TKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIR
NELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQ
RLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKE
CLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPI
INSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDL
CRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNII
QLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRI
EELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSL
LNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNT
ILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSL
RIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSN
IEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETI
NDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTD
EKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYES
KLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQ
LENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNG
PGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHS
SIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTA
LKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKER
QGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQN
AKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQR
QIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNI
NMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVE
ERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKL
RAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPP
KSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQN
DNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRN
VQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTED
EEEKETDKVNDENSI |
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References |
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External Links | Resource | Link |
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Saccharomyces Genome Database | MLP1 | Uniprot ID | Q02455 | Uniprot Name | MLP1 |
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General Reference | Not Available |
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