Methionine aminopeptidase 1 (Q01662)

Identification
NameMethionine aminopeptidase 1
Synonyms
  • MAP 1
  • MetAP 1
  • Peptidase M 1
Gene NameMAP1
Enzyme Class
Biological Properties
General FunctionInvolved in aminopeptidase activity
Specific FunctionRemoves the amino-terminal methionine from nascent proteins
Cellular LocationCytoplasmic
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00318L-MethionineShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
peptidase activity, acting on L-amino acid peptides
metallopeptidase activity
metalloexopeptidase activity
exopeptidase activity
aminopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
Process
proteolysis
metabolic process
macromolecule metabolic process
cellular process
protein metabolic process
Gene Properties
Chromosome Locationchromosome 12
LocusYLR244C
Gene Sequence>1164 bp ATGAGCACTGCAACTACAACAGTTACTACCTCCGATCAGGCTTCTCATCCTACCAAGATA TATTGCTCCGGTTTGCAATGTGGTAGAGAAACTTCGTCCCAAATGAAATGCCCTGTTTGT CTAAAACAAGGCATCGTTTCCATTTTCTGCGACACAAGCTGTTATGAAAACAACTACAAA GCTCACAAAGCTTTGCACAATGCTAAGGACGGCTTGGAAGGTGCTTATGATCCTTTCCCA AAATTCAAATATTCTGGTAAAGTGAAGGCTTCATATCCACTTACCCCAAGAAGGTATGTC CCTGAAGATATTCCTAAACCGGACTGGGCCGCTAATGGGCTACCAGTCAGTGAACAAAGA AATGATAGACTTAACAACATCCCTATATACAAGAAAGATCAAATTAAGAAGATTAGAAAG GCATGTATGTTGGGTAGAGAAGTTCTTGATATTGCCGCTGCCCATGTCAGACCAGGCATC ACTACAGATGAATTAGATGAAATCGTCCACAATGAAACAATTAAGAGAGGTGCCTACCCT TCCCCTCTTAATTATTACAACTTTCCTAAATCGCTTTGTACCTCTGTCAATGAAGTTATT TGTCACGGTGTGCCCGATAAAACTGTCTTGAAGGAAGGTGATATTGTCAATTTAGATGTT TCCTTATACTACCAAGGTTATCATGCAGACTTGAATGAGACATATTATGTCGGCGAAAAC ATTTCTAAGGAAGCTCTTAATACTACTGAGACCTCAAGAGAATGTTTGAAACTAGCCATT AAAATGTGTAAGCCAGGTACCACCTTCCAAGAGTTAGGTGATCATATTGAAAAACACGCT ACCGAAAATAAGTGCAGTGTAGTAAGAACTTATTGTGGACATGGTGTTGGTGAATTTTTC CATTGTTCCCCAAATATTCCCCACTACGCCAAGAATAGAACACCTGGTGTTATGAAACCA GGTATGGTTTTCACCATCGAACCTATGATTAATGAAGGTACTTGGAAGGATATGACCTGG CCTGATGACTGGACTTCTACCACCCAAGACGGTAAACTGAGTGCTCAATTTGAACATACA CTGTTGGTTACCGAACATGGTGTTGAAATCCTAACAGCCAGGAATAAGAAATCACCAGGT GGCCCAAGACAGAGAATTAAATAG
Protein Properties
Pfam Domain Function
Protein Residues387
Protein Molecular Weight43373.0
Protein Theoretical pI7.96
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Methionine aminopeptidase 1 MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYK AHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQR NDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYP SPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGEN ISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFF HCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHT LLVTEHGVEILTARNKKSPGGPRQRIK
References
External Links
ResourceLink
Saccharomyces Genome Database MAP1
Uniprot IDQ01662
Uniprot NameAMPM1_YEAST
GenBank Gene IDM77092
Genebank Protein ID975723
General Reference
  • Chang, Y. H., Teichert, U., Smith, J. A. (1992). "Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae." J Biol Chem 267:8007-8011.1569059
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Walker, K. W., Bradshaw, R. A. (1998). "Yeast methionine aminopeptidase I can utilize either Zn2+ or Co2+ as a cofactor: a case of mistaken identity?" Protein Sci 7:2684-2687.9865965
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106