Cytochrome c oxidase subunit 6B (Q01519)

Identification
NameCytochrome c oxidase subunit 6B
Synonyms
  • Cytochrome c oxidase polypeptide VIb
Gene NameCOX12
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in cytochrome-c oxidase activity
Specific FunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
mitochondrion
Function
catalytic activity
oxidoreductase activity
heme-copper terminal oxidase activity
cytochrome-c oxidase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>252 bp ATGGCTGATCAAGAAAACTCTCCACTACATACAGTTGGTTTCGATGCTAGATTTCCCCAA CAAAACCAAACAAAGCATTGTTGGCAATCTTATGTGGATTATCACAAGTGTGTTAATATG AAGGGCGAAGATTTTGCTCCGTGCAAGGTCTTTTGGAAGACCTATAACGCCTTATGTCCC CTAGACTGGATCGAAAAATGGGATGATCAAAGAGAAAAAGGTATTTTCGCAGGTGATATC AACTCAGACTAA
Protein Properties
Pfam Domain Function
Protein Residues83
Protein Molecular Weight9787.90039
Protein Theoretical pI5.02
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome c oxidase subunit 6B MADQENSPLHTVGFDARFPQQNQTKHCWQSYVDYHKCVNMKGEDFAPCKVFWKTYNALCP LDWIEKWDDQREKGIFAGDINSD
References
External Links
ResourceLink
Saccharomyces Genome Database COX12
Uniprot IDQ01519
Uniprot NameCOX12_YEAST
GenBank Gene IDAY557925
Genebank Protein ID45269741
General Reference
  • LaMarche, A. E., Abate, M. I., Chan, S. H., Trumpower, B. L. (1992). "Isolation and characterization of COX12, the nuclear gene for a previously unrecognized subunit of Saccharomyces cerevisiae cytochrome c oxidase." J Biol Chem 267:22473-22480.1331057
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Taanman, J. W., Capaldi, R. A. (1992). "Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme." J Biol Chem 267:22481-22485.1331058
  • Geier, B. M., Schagger, H., Ortwein, C., Link, T. A., Hagen, W. R., Brandt, U., Von Jagow, G. (1995). "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Eur J Biochem 227:296-302.7851399
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666