ATP synthase subunit e, mitochondrial (P81449)

Identification
NameATP synthase subunit e, mitochondrial
Synonyms
  • ATPase subunit e
  • Translocase of the inner membrane protein 11
Gene NameTIM11
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in hydrogen ion transmembrane transporter acti
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane
Cellular LocationMitochondrion. Mitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
cell part
membrane part
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
mitochondrial membrane part
Function
hydrogen ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
Process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>291 bp ATGTCGACAGTTAATGTTTTGAGATACTCTGCGTTGGGTTTGGGGCTATTTTTTGGTTTT AGAAATGATATGATTTTGAAGTGTAATGCTAAGAAGAAAGAGGAGCAGGCACAGTACGAG GAGAAATTGAAGCTGGTAGAGGAGGCAAAGAAGGAATACGCCAAGCTACACCCTGTAGTA ACTCCTAAAGATGTGCCTGCGAACGCCTCATTTAATTTGGAAGATCCTAATATAGATTTT GAAAGAGTTATTCTTAACGCCGTTGAATCCCTGAAGGAAGCTTCAACATAA
Protein Properties
Pfam Domain Function
Protein Residues96
Protein Molecular Weight10875.40039
Protein Theoretical pI5.91
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>ATP synthase subunit e, mitochondrial MSTVNVLRYSALGLGLFFGFRNDMILKCNAKKKEEQAQYEEKLKLVEEAKKEYAKLHPVV TPKDVPANASFNLEDPNIDFERVILNAVESLKEAST
References
External Links
ResourceLink
Saccharomyces Genome Database TIM11
Uniprot IDP81449
Uniprot NameATPJ_YEAST
GenBank Gene IDAY557720
Genebank Protein ID45269331
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Arnold, I., Pfeiffer, K., Neupert, W., Stuart, R. A., Schagger, H. (1998). "Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits." EMBO J 17:7170-7178.9857174
  • Arnold, I., Bauer, M. F., Brunner, M., Neupert, W., Stuart, R. A. (1997). "Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11." FEBS Lett 411:195-200.9271204
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106