| Identification |
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| Name | ATP synthase subunit 9, mitochondrial |
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| Synonyms | - Lipid-binding protein
- Oligomycin resistance protein 1
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| Gene Name | ATP9 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Energy production and conversion |
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| Specific Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element |
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| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein (Potential) |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | |
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| GO Classification | | Component |
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| macromolecular complex | | protein complex | | proton-transporting two-sector ATPase complex, proton-transporting domain | | proton-transporting ATP synthase complex, coupling factor F(o) | | Function |
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| transporter activity | | transmembrane transporter activity | | substrate-specific transmembrane transporter activity | | ion transmembrane transporter activity | | cation transmembrane transporter activity | | inorganic cation transmembrane transporter activity | | monovalent inorganic cation transmembrane transporter activity | | hydrogen ion transmembrane transporter activity | | Process |
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| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | | nucleobase, nucleoside and nucleotide metabolic process | | nucleoside phosphate metabolic process | | nucleotide metabolic process | | purine nucleotide metabolic process | | metabolic process | | purine nucleotide biosynthetic process | | purine nucleoside triphosphate biosynthetic process | | purine ribonucleoside triphosphate biosynthetic process | | ATP biosynthetic process | | ATP synthesis coupled proton transport | | nitrogen compound metabolic process | | cellular nitrogen compound metabolic process |
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >231 bp
ATGCAATTAGTATTAGCAGCTAAATATATTGGAGCAGGTATCTCAACAATTGGTTTATTA
GGAGCAGGTATTGGTATTGCTATCGTATTCGCAGCTTTAATTAATGGTGTATCAAGAAAC
CCATCAATTAAAGACCTAGTATTCCCTATGGCTATTTTAGGTTTCGCCTTATCAGAAGCT
ACAGGTTTATTCTGTTTAATGGTTTCATTCTTATTATTATTCGGTGTATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 76 |
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| Protein Molecular Weight | 7759.2998 |
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| Protein Theoretical pI | 8.52 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >ATP synthase subunit 9, mitochondrial
MQLVLAAKYIGAGISTIGLLGAGIGIAIVFAALINGVSRNPSIKDTVFPMAILGFALSEA
TGLFCLMVSFLLLFGV |
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| References |
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| External Links | |
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| General Reference | - Hensgens, L. A., Grivell, L. A., Borst, P., Bos, J. L. (1979). "Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex." Proc Natl Acad Sci U S A 76:1663-1667.156363
- Macino, G., Tzagoloff, A. (1979). "Assembly of the mitochondrial membrane system. The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae." J Biol Chem 254:4617-4623.155696
- Ooi, B. G., McMullen, G. L., Linnane, A. W., Nagley, P., Novitski, C. E. (1985). "Biogenesis of mitochondria: DNA sequence analysis of mit- mutations in the mitochondrial oli1 gene coding for mitochondrial ATPase subunit 9 in Saccharomyces cerevisiae." Nucleic Acids Res 13:1327-1339.2860638
- Foury, F., Roganti, T., Lecrenier, N., Purnelle, B. (1998). "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae." FEBS Lett 440:325-331.9872396
- Michon, T., Galante, M., Velours, J. (1988). "NH2-terminal sequence of the isolated yeast ATP synthase subunit 6 reveals post-translational cleavage." Eur J Biochem 172:621-625.2894987
- Stock, D., Leslie, A. G., Walker, J. E. (1999). "Molecular architecture of the rotary motor in ATP synthase." Science 286:1700-1705.10576729
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