MAP kinase kinase kinase SSK2 (P53599)

Identification
NameMAP kinase kinase kinase SSK2
Synonyms
  • Suppressor of sensor kinase 2
Gene NameSSK2
Enzyme ClassNot Available
Biological Properties
General Functionstress-activated MAPK cascade
Specific FunctionKinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
actin binding
cellular hyperosmotic response
ATP binding
cytosol
cellular bud neck
cellular bud tip
incipient cellular bud site
protein phosphorylation
cell cortex
protein autophosphorylation
positive regulation of actin cytoskeleton reorganization
MAP kinase kinase kinase activity
MAPK cascade involved in osmosensory signaling pathway
stress-activated MAPK cascade
osmosensory signaling via phosphorelay pathway
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>4740 bp ATGTCGCATTCAGACTACTTCAATTATAAGCCTTACGGCGATTCCACGGAAAAGCCCAGC AGCTCCAAGATGAGGCAGTCATCTTCATCATCTTCATCTAGACTAAGGTCGGAAAGTTTA GGGCGAAATTCCAATACTACGCAGGCTCGAGTAGCGTCATCGCCCATCAGCCCAGGGCTG CATTCTACCCAGTACTTTAGATCACCAAACGCTGTTTACAGCCCTGGAGAGTCTCCATTA AATACAGTACAGCTATTCAATCGTCTTCCGGGTATACCTCAAGGTCAGTTTTTTCATCAA AATGCCATTTCTGGGTCCTCCAGCTCCTCGGCAAGATCTAGTAGACGGCCCTCGAATATT GGTCTTCCTCTACCAAAAAATCCTCAGCAGTCTCTACCGAAGTTGTCTACTCAACCTGTT CCTGTACATAAGAAAGTTGAGGCTAGTAAAACAGAGAGCGAGATTATTAAGAAGCCCGCT CCCGTGAATAGTAATCAAGATCCATTATTGACGACCCCAACGTTAGTGATATCACCAGAA CTGGCTTCACTAAATACAACGAATACATCGATTATGTCAACGCCACAAAATATTACAAAC CAAACTTCGAACAAACACATTCCCACCAGATCGCAACCAAATGGGTCAACAAGTTCCTCC ACTTTGCAGGATATTGTCACGACAAATAGCTCGCAACGGTCTGTAGGCCACCATGGTGGA AGCACAACGAGCCTCCGAACATACAAAAAACAATATGTATTAAATGAACAGTTATATTTA AGAAAAATGAGAAACCGTGCTAATGATGATTATTACACTAGAGGTATAGTCGCATCATCC AACTTTGAAGATGACGAAGAAAATTTTAGTAACAAAGGTGAAGATGACTTAGAACTAGAA ATGGATGATCTTTTAAAGGTAGAAGGTGAGGATAAAGATAACGACTTCAATTTTGGTTAT AATTTTATTACGTCGAGCACAAAAAATAATGAAAATGTTGTTTCGATGAGCCTAAATTAT CTAAAGGGCAAATTGGATTGGTTGAGGGATGTGAACAATGATCAACCGTGTGAAATAGAA GATGAGGAGTGGCATTCCATACTGGGGAGCGAGGATTTGCTGTCAAAATTGTTACAAAAT CCTATGGTGAACAACCGATTTGAATGGCAAACAATGTTATCTAAGGTACTGAAGGGAGAT ATTGTGAGGAATGAAAAAACGAAGATTGCAAATCAAGGGAAAGGCCCTGGCTTCAATACT CAGTTTTCAGATGACATTTGGATTGAGTTGAAGGCATGGATGAATGGGAGGACCGTGGAA GATCAGAACAAATCTCTGAGGATTTTTAGGGATTCTACTGACTCCGTATTTCAAGAAATC ATGGCCTTTAAACTAGAAGATAATATGAGCGCTGACGAGGCTGCAGAGACTATCAAATCA CTAGTAGACAAATATTATAGAGTCTTAAATCTATGGCCTAACATTAAAAGAATGCATGCT GAAAAACCCATTACTAAAACAGAAGCATTCAGGAATCGAATAGATACTTTGAATAGTTGG CTTAATTTCAAATTTAACTTTGATACTAATATTGCGTACCTGAAAAAATGGATAGTTGGC AATAAAGAGCTAGAAAGCACTACCGAAGTGGATAACACCACCGTGAATTTGGATGATCCA GCCGTTTTCGCCACTAATTGTAAACGCTTTGCGGAGCAAATTATGAAGGAAAAGGATATT GAACTGATATTTCAAAAAAAAATATTCTTTCCATTAGCACCATGGATTTTGAAGGCCAAA TTTTTCTTCTTGAAATACCAAAAAACTTGGAATGAATTGAATCTATCTTATTTGGATCAA GATCTGGAATTTTTATTGATGTTTCCAATGCGTTTGGTAAAAGATATAATACTAATTCGC CTATCTTACGCGAAGAAAATACAGAATCCAACCTTGATGATGATCGATCAAATGATGGAC GATTTTAGTACATATATTAAGTTGGCAGTCCAAATGAAATTCACTGTTGCTTCTTACTGT AATGACTGGTTTTTTAAAGTGAAAATCGATCCCGAATTTGATCATACCGTTGTTGAAGGA TTGGAATATTTTTTCTCCATTTTGGAACTGAGAATATTATATAGTGGCAAAAACTCATTC AAGACTTCTAAAGAACCTGATCTGTTATTAAAATATTGGGAAATGTTTAGAAACGTCGGC TATTATATTGATGATGCAGGCGAACTGATCGCAGCAGAATTTACGAAGTTGACACTTAGA TTGGTTCACAGATTGCACGCTTACCTTTTAAGGCAGCAAAACACTCCGCCAAAATTAGAG AATGAAGCTGCTGCTGAAAAATGGCTGGTGCAAATATTCGAAATACTTGGATCCATGAAA AGAAAACTCAATAGATTCACCAATATTTTGACAAAAGCATTTCAAAATTTTGTCCGCTAC AAGATAGAAGATCACAACTATCTGCTAAAGCAACTAAAAGAAACAGGCCACTTTCTTATA TACACAGGAGGTTACCTAGAGCAAAATGGTACTTATTTAATTGGTAGCCCAGAGCTATTA GGCTGTAAAGATGATGATATTTTAAGAATCATTAAGAATTCAGACATCGGTTGTGATTTA GTGCCTAAGCTAGAAATTAATAACAGTCTGACAATTTATAATGCTTTGGATGATAATTGG AACTCCAACTCATCACTGGGTTCAGATATCTCGAATGATGGTACCCCATTTTATTATATC AAAAACGATTTGACCACCCAGCCTAGATCTTATAACGGTAATAGAGTCAATCGTGAACCG GATTTTGAAAACAGCAGGAGCACGGAGGAAGAGTTTTATGAACTGGAGACAAGATTGAAC TCTCTTGGTTATGTATTGGTATTGACTCCGCAAGAGCCATTACTTTGGGAGGGTGAGATG TATAATCTATCCGATAACAAAACAATTAAACCAGAGGGATTGAACTTGAAAGTAATTCCT AATTCAATAGATTTGATGTGCCAAGGATCCAGTTATGCCTTAGAATACCAATGTGACAGG TTCCAACAGATATCTGGTAGCTCAGTTTCTTTCTTGGAAAAAAAATCTTCCTCAGAAACG GTTAAAAACAACTTACAAAGGATAAATAAAGCATATTTCAGATGCACGTACAGTGTTCTG AAGAACTATACAAAGATTGTGACCACGTTCAAGAAGGTAAGTCCTGTCAATGATTTATTG AATAATATTTTCCTTTTTGGGAGGGATTTTGGTCTGAACTTTTTGAGAATTAATGTTGCC AACAATGAAAAAAGATCCATTATAATACTTTTAATGATGCGGTTAAGTATCGGATGGCTG AAGTTCTTAGCTGAAGACTGTGATCCGACTGATCAAAGGGTATTTAGGTGGTGTGTCACG TCAATGGAGTTCGCGATGCATATGGTAAGCGGTTGGAACATACTAGCTCTTGATGAATGC CAATTTTCTTCTTTAAAACAAAAAATTTCAGAATGCATGTCATTACTTATTTCTCATTTT GATATAATAGGCGCACGCTCCATAGAAGTTGAGAAAATCAATCAACAAGCTAGATCAAAT CTTGATTTGGAAGATGTGTTTGACGATGATATGATGCTACAAGTGAATTCCGAGTTCCGA GTACAAAGTATAATGGAATTGGAAGAAAGGATAAAGCGGAATCCTCATCAAACTGGTAAA GTAATTGATGATAGTGACAAAGGTAACAAGTACCTTGTTTCTTTGGCATCTTCCATATCG AACGTTTCTATGAGATGGCAAAAGAGGAACTTTATTGGTGGCGGTACTTTTGGAAGGGTA TATTCTGCTGTTGATTTGGATAATGGTGAGATTTTAGCAGTCAAGGAAATCAATATTCAA GATAGCAAATCAATGCAAAAAATATTCCCCTTAATCAAGGAGGAAATGAGTGTCTTAGAG ATATTGAACCATCCAAATATAGTTTCATATTACGGTGTTGAAGTTCATCGTGATAAAGTT AACATCTTTATGGAATATTGTGAAGGCGGTTCCCTAGCAGCTCTTTTGGAGCATGGTCGT ATTGAAGATGAAATGGTCACTCAAGTCTACACTTTACAATTGCTAGAAGGACTTGCATAT TTGCATGAATCCGGCATTGTTCACCGTGATGTTAAACCCGAAAACATCCTACTAGATTTT AATGGTGTTATTAAGTATGTTGATTTTGGTGCTGCTAAAAAAATTGCTAATAATGGAACT AGATTGGCAAGTATGAACAAAATCGAAAACGCAGATGGTGAACACGAAGATGTTACCCAT GTTTCTGATTCAAAGGCAGTGAAAAATAACGAAAATGCTCTATTAGACATGATGGGAACT CCTATGTACATGGCTCCAGAATCCATCACTGGATCTACCACCAAAGGCAAACTTGGGGCA GACGATGTTTGGTCGTTAGGCTGCGTGGTATTAGAAATGATCACTGGTAGACGGCCATGG GCTAACTTAGATAATGAATGGGCTATCATGTACCATGTTGCTGCAGGACATACCCCACAA TTCCCTACTAAGGATGAAGTGTCGTCTGCTGGTATGAAATTTCTGGAAAGATGTCTTATT CAAAACCCCTCCAAGAGAGCCAGTGCGGTTGAGCTGTTGATGGATCCTTGGATTGTACAA ATTAGAGAAATAGCCTTTGGCGACGATTCTTCCTCTACAGATACTGAGGAAAGAGAGTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1579
Protein Molecular Weight180526.08
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>MAP kinase kinase kinase SSK2 MSHSDYFNYKPYGDSTEKPSSSKMRQSSSSSSSRLRSESLGRNSNTTQARVASSPISPGL HSTQYFRSPNAVYSPGESPLNTVQLFNRLPGIPQGQFFHQNAISGSSSSSARSSRRPSNI GLPLPKNPQQSLPKLSTQPVPVHKKVEASKTESEIIKKPAPVNSNQDPLLTTPTLVISPE LASLNTTNTSIMSTPQNITNQTSNKHIPTRSQPNGSTSSSTLQDIVTTNSSQRSVGHHGG STTSLRTYKKQYVLNEQLYLRKMRNRANDDYYTRGIVASSNFEDDEENFSNKGEDDLELE MDDLLKVEGEDKDNDFNFGYNFITSSTKNNENVVSMSLNYLKGKLDWLRDVNNDQPCEIE DEEWHSILGSEDLLSKLLQNPMVNNRFEWQTMLSKVLKGDIVRNEKTKIANQGKGPGFNT QFSDDIWIELKAWMNGRTVEDQNKSLRIFRDSTDSVFQEIMAFKLEDNMSADEAAETIKS LVDKYYRVLNLWPNIKRMHAEKPITKTEAFRNRIDTLNSWLNFKFNFDTNIAYLKKWIVG NKELESTTEVDNTTVNLDDPAVFATNCKRFAEQIMKEKDIELIFQKKIFFPLAPWILKAK FFFLKYQKTWNELNLSYLDQDLEFLLMFPMRLVKDIILIRLSYAKKIQNPTLMMIDQMMD DFSTYIKLAVQMKFTVASYCNDWFFKVKIDPEFDHTVVEGLEYFFSILELRILYSGKNSF KTSKEPDLLLKYWEMFRNVGYYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLE NEAAAEKWLVQIFEILGSMKRKLNRFTNILTKAFQNFVRYKIEDHNYLLKQLKETGHFLI YTGGYLEQNGTYLIGSPELLGCKDDDILRIIKNSDIGCDLVPKLEINNSLTIYNALDDNW NSNSSLGSDISNDGTPFYYIKNDLTTQPRSYNGNRVNREPDFENSRSTEEEFYELETRLN SLGYVLVLTPQEPLLWEGEMYNLSDNKTIKPEGLNLKVIPNSIDLMCQGSSYALEYQCDR FQQISGSSVSFLEKKSSSETVKNNLQRINKAYFRCTYSVLKNYTKIVTTFKKVSPVNDLL NNIFLFGRDFGLNFLRINVANNEKRSIIILLMMRLSIGWLKFLAEDCDPTDQRVFRWCVT SMEFAMHMVSGWNILALDECQFSSLKQKISECMSLLISHFDIIGARSIEVEKINQQARSN LDLEDVFDDDMMLQVNSEFRVQSIMELEERIKRNPHQTGKVIDDSDKGNKYLVSLASSIS NVSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLE ILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAY LHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTH VSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPW ANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWIVQ IREIAFGDDSSSTDTEERE
References
External Links
ResourceLink
Saccharomyces Genome Database SSK2
Uniprot IDP53599
Uniprot NameSSK2
General ReferenceNot Available