Target of rapamycin complex 2 subunit BIT61 (P47041)

Identification
NameTarget of rapamycin complex 2 subunit BIT61
Synonyms
  • TORC2 subunit BIT61
  • 61 kDa binding partner of TOR2 protein
Gene NameBIT61
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionComponent of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway
Cellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1632 bp ATGACAGCAGAAGATATACTCCTTCGAGAAAGAACATCTACTACGACACAACGCCCTGTC AATAGCGAACAATACCTTAATGTGCAATTAGCCACAGCCCCAGTAAAAAATTTTCAGACT ACAAGCGAGATTAGCCGGCAAACTCTTGTAGACACATCAAATGATGACGTTTATTCCATC AAGAATTTGAAGGGCTCGAGGAACCCCATTAGCCCTAGTGTTTCTAACGTTGGCTTCCAA TCCATATTCCATACAGTAGATCATCCTCGATCGAAGGTCAGTGTGGCCTCAAATCATTCC TTGAGGAGCAATGACAATGCCTCAGCTGCAACATCTAAATCTGGTTCTTCTCAGATAGGG GAATCTCATAGCGTTGACACGGTGGAGTGCTCGAACAATCTATCTAAAAAGTTATCTTCT GATGCAATATCCATTACTCAGAAAAGTTTACACTCCACGCCCTCCGGCAGGTATATGAAA GGAAAGGCTTCTGGCTTTTTTAATAGGAGAAACAGAGCACATACGACCATTTCATCGGAT CCTGCCTCCTTTTTGACAGATTCAAGCACCTTACATAATAGTTCACATTCATTTCGAAAC GTGATTAAGAACTTTTTCCAAAATAAAAGCCACAGGCACATTGGTCAAGATGCTATCGAG CCTGCAATTCCAAATTCCTTGAGTAAATTTCTGCATTCCTCTTACGGAAGACATAAATCT CCGTCACAATTTATTCATACTAATGCGGGGCAACTTGTGGACTCAGGAACTTCTGTGTAC TCATTGAATGTTAATCCATCTGGTGTCAATCCCAACACAATCGTTGAGGATCCGCTTTCT GGAACTGATCCTGCCTCACCGAATCCGGTCTCAATGTTACACGACCTTTTAAGAAATTTA CCATCTCTGGAAGCTAACTATAAACACTTCAACTCCCAAGAACTGACAACCCTAACAAAT AATATTTGGAATATATTTTGTAGTAACGTAGCAGAATTATTCAGAACTCAAAGAATATGG AAACTCAGGGCCAAAATAGAAAATTTTAACGAAGTTTTAGAATTCTATTGCATTTTAAAA ACAGATCCAAGAGTCACACATAGCGGCATGAATAGAATTATCAGCGATTTGAAAGAATTT TTGGTTAGTTCCCTATACAATTTAGAAAACCAAATTGTTTTTAACTATTCTAATGAAGAC ACAATAAATAACGCATTGAAAAGATTAGGCGTTATATGGCGGATATTTTATCAAGAGGTA TATTATGATTTAGCCGCTGTGTTATTACCGTTGGATCAGAGTATCAGAGAAGATGGTAAT TCTACGGTTTTAAAGTCAGGCAATGAAAGTCGGACTCACATTAATGGTAATTATTCTATT GGGTTTCTTTTGCTTATGTGCTTTAGAGATTCAATAGTCTTACCTTGTTATGAAAACTTC GTAAATAGTAACGATGGTATCAGCAAAAGTTTTCAACTTTACATTTTCAATCAAGAAGAA GAAAGTAATGTCACAGAAACAGATAAATTGACATTACTGCAGTGTTTTGGCATATTGAGT ACCATTCAAAGTAATGATAGAAATCAACGAATTATCGAAGAGTTATTAGCAGGCATTAGA ATGAGTATATAG
Protein Properties
Pfam Domain Function
Protein Residues543
Protein Molecular Weight60840.39844
Protein Theoretical pI7.48
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Target of rapamycin complex 2 subunit BIT61 MTAEDILLRERTSTTTQRPVNSEQYLNVQLATAPVKNFQTTSEISRQTLVDTSNDDVYSI KNLKGSRNPISPSVSNVGFQSIFHTVDHPRSKVSVASNHSLRSNDNASAATSKSGSSQIG ESHSVDTVECSNNLSKKLSSDAISITQKSLHSTPSGRYMKGKASGFFNRRNRAHTTISSD PASFLTDSSTLHNSSHSFRNVIKNFFQNKSHRHIGQDAIEPAIPNSLSKFLHSSYGRHKS PSQFIHTNAGQLVDSGTSVYSLNVNPSGVNPNTIVEDPLSGTDPASPNPVSMLHDLLRNL PSLEANYKHFNSQELTTLTNNIWNIFCSNVAELFRTQRIWKLRAKIENFNEVLEFYCILK TDPRVTHSGMNRIISDLKEFLVSSLYNLENQIVFNYSNEDTINNALKRLGVIWRIFYQEV YYDLAAVLLPLDQSIREDGNSTVLKSGNESRTHINGNYSIGFLLLMCFRDSIVLPCYENF VNSNDGISKSFQLYIFNQEEESNVTETDKLTLLQCFGILSTIQSNDRNQRIIEELLAGIR MSI
References
External Links
ResourceLink
Saccharomyces Genome Database BIT61
Uniprot IDP47041
Uniprot NameBIT61_YEAST
GenBank Gene IDAY693068
Genebank Protein ID51013587
General Reference
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Reinke, A., Anderson, S., McCaffery, J. M., Yates, J. 3rd, Aronova, S., Chu, S., Fairclough, S., Iverson, C., Wedaman, K. P., Powers, T. (2004). "TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae." J Biol Chem 279:14752-14762.14736892
  • Fadri, M., Daquinag, A., Wang, S., Xue, T., Kunz, J. (2005). "The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2." Mol Biol Cell 16:1883-1900.15689497
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956