Protein BNI1 (P41832)

Identification
NameProtein BNI1
Synonyms
  • Pointed projection formation protein 3
  • Sensitive to high expression protein 5
  • Synthetic lethal 39
Gene NameBNI1
Enzyme ClassNot Available
Biological Properties
General Functionregulation of protein localization
Specific FunctionRequired for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
barbed-end actin filament capping
formin-nucleated actin cable assembly
actin filament
ruffle membrane
cellular bud neck
actin nucleation
cellular bud tip
actomyosin contractile ring actin filament bundle assembly
incipient cellular bud site
mating projection tip
regulation of protein localization
identical protein binding
budding cell apical bud growth
polarisome
positive regulation of actin cytoskeleton reorganization
establishment of mitotic spindle orientation
profilin binding
actin filament bundle assembly
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>5862 bp ATGTTGAAGAATTCAGGCTCCAAACATTCGAACTCAAAGGAAAGTCATTCGAATTCGAGT TCTGGTATATTCCAAAATTTGAAGCGTTTGGCTAACTCAAATGCAACGAATAGCAATACG GGTTCTCCGACCTATGCATCCCAACAACAGCACTCTCCAGTGGGAAACGAAGTGTCCACT TCACCTGCATCTTCGTCATCTTTTAGAAAACTGAATGCACCTTCTAGGTCTACATCTACT GAGGCGAGGCCGTTGAATAAAAAATCGACATTAAACACACAAAACTTGTCTCAATATATG AATGGTAAATTAAGTGGAGATGTTCCCGTATCCTCACAGCACGCAAGGTCGCATTCAATG CAATCGAAATATTCGTATTCCAAGAGGAATTCTTCACAGGCGTCCAATAAGCTAACAAGG CAGCATACCGGGCAAAGTCACTCCGCATCAAGTCTTCTCTCTCAAGGTTCGCTAACTAAC TTGAGCAAATTCACTACACCCGATGGTAAAATTTATTTAGAAATGCCGTCGGACCCATAC GAGGTGGAAGTTTTGTTTGAAGATATTATGTATAAAAGAAATATTTTTCAGTCTTTATCA GAGGACAAACAAGAAGCTCTGATGGGCTACAGCATTGAGAAGAAATGGCTGATTGTTAAG CAGGATTTACAAAATGAGCTAAAAAAAATGCGAGCAAACACTACATCTTCTTCCACTGCC TCCAGAACTTCGATGGCGTCGGACCATCATCCTATCCTTACGGCTAATTCATCTCTTTCG TCTCCCAAATCTGTTTTGATGACAAGCGCCTCTTCTCCCACCTCAACTGTATACAGCAAC AGTTTAAATCATTCTACTACTCTTTCATCGGTAGGTACGTCAACCTCGAAGGGGAAAAAA TTAGTGAGCGGGAGTTTGAAAAAGCAGCCATCTCTAAACAATATTTATAGAGGTGGGGCT GAGAACAATACGAGTGCATCTACTCTTCCAGGAGACAGAACAAACAGACCACCGATACAT TATGTGCAACGAATCCTGGCAGACAAACTTACTAGCGATGAGATGAAAGATTTATGGGTA ACTTTAAGAACTGAACAGTTAGACTGGGTAGACGCTTTTATAGACCATCAGGGTCACATT GCTATGGCTAATGTACTAATGAACTCTATTTATAAGACTGCACCCCGAGAAAACTTGACT AAAGAATTATTAGAGAAAGAAAATTCATTTTTTAAATGCTTCAGAGTCTTATCAATGCTC TCACAAGGTTTGTATGAGTTCAGTACACATAGGTTAATGACTGATACTGTTGCAGAAGGT TTATTCTCTACGAAACTGGCCACAAGGAAAATGGCCACTGAAATTTTTGTTTGTATGCTA GAAAAAAAAAATAAAAGCAGATTCGAAGCAGTTCTTACCTCACTAGATAAAAAGTTTAGG ATAGGGCAAAATCTTCATATGATTCAAAACTTCAAAAAAATGCCCCAGTATTTCTCTCAT TTAACCTTGGAAAGTCATTTGAAAATTATTCAAGCCTGGTTATTTGCCGTTGAACAAACT TTAGATGGAAGAGGAAAAATGGGTTCCTTAGTAGGCGCGTCGGATGAATTTAAAAATGGT GGGGGTGAAAATGCGATTCTAGAATACTGCCAATGGACAATGGTTTTTATCAATCATTTA TGCTCTTGCTCTGATAACATAAATCAAAGAATGCTATTAAGGACGAAACTAGAAAATTGT GGAATTTTACGAATTATGAACAAAATAAAACTGCTAGATTACGACAAGGTAATTGACCAA ATTGAGTTATATGACAATAATAAACTTGACGATTTTAACGTTAAATTAGAGGCCAACAAT AAGGCTTTTAATGTAGATTTACACGATCCACTATCATTATTAAAAAACCTTTGGGATATA TGTAAAGGTACCGAGAATGAAAAGCTTTTAGTATCTTTAGTTCAACATCTTTTCCTTTCT AGTTCAAAGTTAATAGAAGAAAACCAAAATTCCTCTAAACTTACTAAGCAATTGAAACTT ATGGATTCTTTGGTGACTAATGTTAGTGTTGCCTCAACTTCTGATGAAGAAACTAATATG AATATGGCTATCCAGCGGCTTTACGATGCCATGCAGACTGATGAAGTTGCACGTCGAGCT ATATTAGAAAGTAGAGCTCTAACGAAGAAATTGGAAGAAATTCAGGCAGAAAGGGATTCT TTAAGTGAAAAGTTAAGCAAGGCGGAGCACGGACTCGTTGGACAGTTAGAAGATGAGTTG CATGAGAGAGATCGTATTTTAGCTAAGAATCAGAGAGTTATGCAGCAGCTGGAAGCTGAG TTAGAAGAGTTGAAAAAGAAGCATCTTTTGGAAAAGCATCAGCAAGAGGTAGAATTGAGA AAAATGTTGACTATATTGAATTCGAGGCCTGAAGAAAGCTTCAATAAGAATGAAGGCACC AGAGGTATGAACTCGAGCCTAAATTCTTCAGAGAAAGCGAATATCCAAAAGGTGTTACAG GACGGATTATCAAGAGCAAAAAAGGATTACAAGGATGATTCAAAAAAATTCGGCATGACA CTTCAACCTAATAAGAGATTAAAAATGTTAAGAATGCAAATGGAAAATATTGAAAATGAA GCCAGGCAACTAGAGATGACAAATTTTGCTGAATTTGAGAAAGATCGTCTTGAACCTCCA ATACATATTAAGAAGCCCAAAGTGAAGAAGATGAAAAATAAGGATAGGAAACCTTTAGTC AAGCCTCAAGAGGCGGACGTAAATAAACTAAATGACCTAAGGCGGGCTTTGGCTGAAATC CAAATGGAAAGTAATGATATTTCCAAATTTAACGTCGAAGAACGTGTTAATGAGCTATTT AATGAAAAGAAATCTCTGGCTTTAAAGAGACTGAAAGAACTAGAAACAAAATACAAAGGA TTTGGTATTGACTTTAATGTCGACGAGATTATGGACAGTCCAAAGAAAAATACTGGGGAC GTGGAAACGGAAGAAGACGCTAACTATGCCAGTCTTGACCCTAAGACATATCAGAAAAAG TTAGACGAGATTAATAGAATAACGGACCAGTTGTTAGATATTCAGACTCAAACCGAACAC GAAATACAAGTAGAAGAAGATGGGGAAAGCGATCTTTCCTCTTCAAGTTCTGATGATGAA AGTGAGGAAATATACCAAGACGCATCTCCAACTCAAGAACTAAGGAGCGAACACTCAGAG CTATCTTCAGGATCAGGTCCTGGGTCTTTTCTCGATGCCTTATCTCAAAAATATGGTACT GGTCAAAATGTTACTGCATCGGCTGCTTTTGGAGAGAACAATAACGGTTCGGGTATTGGA CCTCTACATAGTAAAGTTGAAAAGACCTTTATGAACAGACTCAGAAAATCCACCGTGTCT TCTGCTCCATATTTAGAGGAGTTAACACAGAAGGTAAATAAAGTTGAACCATATGAACAA AATGAAGATGAAGGTCTAGATAAAAAATCTTTACCGGAAAACAGCACGGCAAGTGCAGCT TCCGCCTTTGACAAAGCTGAGAAAGACATGAGACAACATGTGGAAAACGGAAAGCAAGGG CGTGTGGTAAATCATGAAGAAGATAAAACAGCGGATTTCAGCGCTGTGAGTAAACTGAAT AATACAGATGGCGCAGAAGATCTCTCTACTCAATCATCTGTACTCTCCTCACAGCCGCCA CCGCCTCCTCCTCCTCCTCCTCCAGTTCCCGCCAAATTGTTCGGTGAATCGTTGGAGAAA GAGAAAAAGTCGGAAGACGACACTGTCAAGCAAGAAACTACTGGGGATTCTCCTGCTCCT CCCCCTCCACCACCACCACCTCCTCCTCCACCCATGGCATTGTTCGGCAAACCCAAGGGA GAAACACCACCACCGCCGCCGCTACCATCTGTATTATCTTCATCTACTGATGGCGTCATT CCGCCAGCTCCACCTATGATGCCGGCATCGCAAATCAAATCAGCTGTAACATCACCATTA CTTCCTCAATCGCCCTCATTATTTGAAAAGTATCCTCGTCCACACAAGAAATTAAAGCAA CTGCATTGGGAAAAATTAGATTGTACTGATAATTCTATTTGGGGTACAGGTAAAGCTGAG AAGTTCGCAGATGACTTATACGAAAAGGGTGTTCTTGCTGATTTAGAAAAGGCCTTTGCC GCTAGGGAAATTAAATCATTAGCAAGCAAGCGCAAGGAAGATCTGCAGAAAATTACATTT TTATCCAGGGATATTTCTCAACAGTTTGGTATCAATTTGCATATGTATTCATCACTTTCG GTTGCCGATCTGGTGAAAAAGATTCTAAACTGCGATAGGGATTTTTTGCAAACACCGAGT GTTGTTGAGTTTTTGTCAAAATCTGAAATAATTGAAGTTTCTGTTAATTTAGCTAGGAAT TACGCCCCGTATTCGACAGACTGGGAGGGCGTGAGGAATCTCGAAGATGCCAAGCCCCCT GAAAAAGATCCAAACGATTTACAGAGGGCTGACCAAATTTATTTGCAATTGATGGTTAAT CTAGAATCATACTGGGGTTCACGTATGAGAGCTCTCACAGTGGTTACTTCGTATGAAAGA GAATATAATGAGTTATTGGCAAAGTTAAGAAAAGTCGACAAAGCTGTTAGCGCGCTTCAA GAATCAGATAACTTGCGCAATGTCTTTAATGTTATCTTAGCAGTTGGTAATTTCATGAAC GACACTTCTAAGCAGGCACAAGGTTTCAAACTTTCAACCTTGCAGAGGTTGACGTTTATC AAGGATACTACCAATAGCATGACCTTTCTAAATTACGTCGAAAAAATTGTCAGGTTAAAT TATCCAAGCTTCAATGACTTTCTAAGTGAATTAGAACCTGTATTGGATGTCGTGAAAGTT TCCATTGAGCAGTTAGTTAACGACTGTAAGGACTTTAGCCAATCGATTGTAAACGTAGAG CGTTCAGTTGAAATTGGTAATTTAAGCGATTCCTCAAAGTTTCATCCATTAGATAAAGTT TTGATAAAAACATTGCCCGTGTTACCGGAAGCCAGAAAAAAGGGGGACTTGTTAGAAGAC GAAGTTAAGCTGACTATCATGGAATTTGAAAGTCTGATGCATACGTACGGTGAAGATTCT GGTGATAAGTTTGCAAAAATCTCATTCTTTAAGAAATTTGCAGATTTTATAAATGAATAC AAAAAAGCTCAAGCGCAAAATCTAGCCGCGGAAGAAGAAGAAAGACTTTATATAAAGCAT AAGAAAATAGTGGAAGAACAGCAAAAAAGGGCACAAGAAAAGGAAAAACAAAAAGAGAAC AGCAATTCGCCTTCATCTGAAGGAAATGAAGAGGATGAAGCAGAAGATAGGCGCGCTGTT ATGGATAAACTATTAGAACAGTTGAAAAATGCAGGTCCTGCTAAAAGTGACCCATCTTCC GCCAGAAAGAGAGCCCTAGTGAGGAAAAAATATCTTTCTGAAAAAGACAACGCTCCACAA TTACTCAACGATTTGGATACTGAAGAAGGGTCTATTCTTTATTCTCCAGAAGCTATGGAC CCTACTGCCGATACAGTGATTCACGCTGAATCACCCACTCCGCTTGCCACAAGGGGTGTT ATGAATACCTCTGAAGATTTACCATCGCCATCCAAGACATCTGCGCTGGAAGATCAAGAG GAAATTAGTGACAGAGCTAGAATGTTATTAAAGGAGCTAAGAGGCTCTGACACACCAGTA AAGCAAAATTCCATACTCGATGAACATCTAGAAAAATTGAGGGCCCGCAAGGAAAGATCC ATAGGTGAGGCTAGCACAGGTAACAGGCTAAGTTTCAAATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1953
Protein Molecular Weight219670.66
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Protein BNI1 MLKNSGSKHSNSKESHSNSSSGIFQNLKRLANSNATNSNTGSPTYASQQQHSPVGNEVST SPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNGKLSGDVPVSSQHARSHSM QSKYSYSKRNSSQASNKLTRQHTGQSHSASSLLSQGSLTNLSKFTTPDGKIYLEMPSDPY EVEVLFEDIMYKRNIFQSLSEDKQEALMGYSIEKKWLIVKQDLQNELKKMRANTTSSSTA SRTSMASDHHPILTANSSLSSPKSVLMTSASSPTSTVYSNSLNHSTTLSSVGTSTSKGKK LVSGSLKKQPSLNNIYRGGAENNTSASTLPGDRTNRPPIHYVQRILADKLTSDEMKDLWV TLRTEQLDWVDAFIDHQGHIAMANVLMNSIYKTAPRENLTKELLEKENSFFKCFRVLSML SQGLYEFSTHRLMTDTVAEGLFSTKLATRKMATEIFVCMLEKKNKSRFEAVLTSLDKKFR IGQNLHMIQNFKKMPQYFSHLTLESHLKIIQAWLFAVEQTLDGRGKMGSLVGASDEFKNG GGENAILEYCQWTMVFINHLCSCSDNINQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQ IELYDNNKLDDFNVKLEANNKAFNVDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLS SSKLIEENQNSSKLTKQLKLMDSLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRA ILESRALTKKLEEIQAERDSLSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAE LEELKKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQ DGLSRAKKDYKDDSKKFGMTLQPNKRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPP IHIKKPKVKKMKNKDRKPLVKPQEADVNKLNDLRRALAEIQMESNDISKFNVEERVNELF NEKKSLALKRLKELETKYKGFGIDFNVDEIMDSPKKNTGDVETEEDANYASLDPKTYQKK LDEINRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDDESEEIYQDASPTQELRSEHSE LSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEKTFMNRLRKSTVS SAPYLEELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKDMRQHVENGKQG RVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLFGESLEK EKKSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVI PPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKAE KFADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSRDISQQFGINLHMYSSLS VADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLEDAKPP EKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQ ESDNLRNVFNVILAVGNFMNDTSKQAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIVRLN YPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKV LIKTLPVLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSGDKFAKISFFKKFADFINEY KKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAV MDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKDNAPQLLNDLDTEEGSILYSPEAMD PTADTVIHAESPTPLATRGVMNTSEDLPSPSKTSALEDQEEISDRARMLLKELRGSDTPV KQNSILDEHLEKLRARKERSIGEASTGNRLSFK
References
External Links
ResourceLink
Saccharomyces Genome Database BNI1
Uniprot IDP41832
Uniprot NameBNI1
PDB ID
1UX4
General ReferenceNot Available