Catabolite repression protein CAT5 (P41735)

Identification
NameCatabolite repression protein CAT5
Synonyms
  • Coenzyme Q biosynthesis protein 7
  • Ubiquinone biosynthesis protein COQ7
Gene NameCAT5
Enzyme ClassNot Available
Biological Properties
General FunctionCoenzyme transport and metabolism
Specific FunctionCentral metabolic regulator required for the derepression of PCK1, and thereby gluconeogenesis. Necessary for transcriptional activation of the CAT8 gene. Also involved in the control of expression of other enzymes of gluconeogenesis and those of respiration and the glyoxylate cycle. Also involved in one or more monooxygenase steps of ubiquinone biosynthesis
Cellular LocationMitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
catalytic activity
oxidoreductase activity
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
Process
oxidation reduction
cellular metabolic process
macromolecule metabolic process
protein metabolic process
cofactor metabolic process
coenzyme metabolic process
oxidoreduction coenzyme metabolic process
ubiquinone metabolic process
metabolic process
ubiquinone biosynthetic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>YOR125C Chr 15 ATGTTATCCCGTGTTTCAGTTTTCAAACCTGCCAGCAGAGGCTTTTCCGTCTTATCATCT TTAAAGATAACAGAACATACATCAGCAAAACACACCGAAAAACCTGAGCATGCTCCCAAG TGTCAGAATTTATCAGATGCTCAGGCTGCATTTTTGGACCGTGTTATTCGTGTAGATCAA GCTGGCGAATTAGGTGCAGACTACATCTACGCTGGCCAGTACTTCGTGTTGGCTCATAGG TACCCTCACTTGAAACCTGTGCTAAAGCACATATGGGACCAGGAGATACATCATCATAAT ACTTTTAACAATTTGCAATTGAAAAGGAGAGTCAGGCCTTCCTTATTAACGCCTTTGTGG AAGGCAGGAGCCTTTGCAATGGGGGCTGGTACCGCATTGATTTCTCCAGAAGCAGCTATG GCTTGTACTGAAGCTGTCGAGACAGTAATCGGAGGGCACTACAATGGCCAATTGCGAAAC TTGGCCAATCAATTCAATTTAGAAAGAACAGATGGAACAAAGGGTCCAAGTGAGGAAATC AAATCCTTAACTTCTACTATCCAACAGTTCAGGGATGACGAGCTAGAGCATCTAGACACC GCTATCAAGCATGATTCGTATATGGCAGTTCCATATACAGTTATCACTGAAGGTATTAAA ACGATTTGCAGAGTAGCTATATGGAGTGCCGAAAGAATTTAA
Protein Properties
Pfam Domain Function
Protein Residues233
Protein Molecular Weight26059.5
Protein Theoretical pI8.14
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Catabolite repression protein CAT5 MLSRVSVFKPASRGFSVLSSLKITEHTSAKHTEKPEHAPKCQNLSDAQAAFLDRVIRVDQ AGELGADYIYAGQYFVLAHRYPHLKPVLKHIWDQEIHHHNTFNNLQLKRRVRPSLLTPLW KAGAFAMGAGTALISPEAAMACTEAVETVIGGHYNGQLRNLANQFNLERTDGTKGPSEEI KSLTSTIQQFRDDELEHLDTAIKHDSYMAVPYTVITEGIKTICRVAIWSAERI
References
External Links
ResourceLink
Saccharomyces Genome Database CAT5
Uniprot IDP41735
Uniprot NameCAT5_YEAST
General Reference
  • Proft, M., Kotter, P., Hedges, D., Bojunga, N., Entian, K. D. (1995). "CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae." EMBO J 14:6116-6126.8557031
  • Marbois, B. N., Clarke, C. F. (1996). "The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis." J Biol Chem 271:2995-3004.8621692
  • Wiemann, S., Rechmann, S., Benes, V., Voss, H., Schwager, C., Vlcek, C., Stegemann, J., Zimmermann, J., Erfle, H., Paces, V., Ansorge, W. (1996). "Sequencing and analysis of 51 kb on the right arm of chromosome XV from Saccharomyces cerevisiae reveals 30 open reading frames." Yeast 12:281-288.8904341
  • Voss, H., Benes, V., Andrade, M. A., Valencia, A., Rechmann, S., Teodoru, C., Schwager, C., Paces, V., Sander, C., Ansorge, W. (1997). "DNA sequencing and analysis of 130 kb from yeast chromosome XV." Yeast 13:655-672.9200815
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Jonassen, T., Proft, M., Randez-Gil, F., Schultz, J. R., Marbois, B. N., Entian, K. D., Clarke, C. F. (1998). "Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis." J Biol Chem 273:3351-3357.9452453
  • Kellis, M., Patterson, N., Endrizzi, M., Birren, B., Lander, E. S. (2003). "Sequencing and comparison of yeast species to identify genes and regulatory elements." Nature 423:241-254.12748633
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278