Elongation of fatty acids protein 3 (P40319)

Identification
NameElongation of fatty acids protein 3
Synonyms
  • Protein SRE1
  • Protein SUR4
  • v-SNARE bypass mutant gene 1 protein
Gene NameSUR4
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in fatty acid elongase activity
Specific FunctionAffects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Is essential for the conversion of 24-carbon fatty acids to 26 carbon species
Cellular LocationMembrane; Multi-pass membrane protein (Probable)
SMPDB Pathways
Biosynthesis of unsaturated fatty acids (docosanoyl)PW002408 ThumbThumb?image type=greyscaleThumb?image type=simple
Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)PW002404 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
integral to membrane
cell part
membrane part
intrinsic to membrane
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1038 bp ATGAACACTACCACATCTACTGTTATAGCAGCAGTTGCCGACCAGTTCCAGTCTTTGAAC TCTTCTTCTTCATGTTTCTTGAAGGTTCATGTTCCTTCCATTGAGAACCCATTCGGTATT GAATTATGGCCAATTTTCTCCAAAGTGTTTGAATACTTTAGTGGCTATCCAGCTGAGCAA TTCGAGTTTATTCACAATAAGACTTTCTTGGCTAACGGGTATCATGCTGTTAGTATTATT ATCGTTTATTACATTATTATCTTTGGTGGCCAAGCTATCTTACGCGCCTTGAACGCCTCT CCATTAAAGTTTAAATTGCTTTTCGAGATACACAACTTGTTTTTGACTTCTATTTCTCTA GTTTTATGGTTGCTGATGTTAGAACAGTTGGTTCCTATGGTTTATCACAACGGTCTATTC TGGTCTATCTGCTCTAAGGAAGCCTTCGCACCAAAATTAGTTACTCTTTACTATTTGAAC TATTTGACCAAATTCGTAGAATTGATTGACACTGTGTTTTTAGTTTTGAGAAGAAAGAAG TTATTGTTTTTGCACACTTACCATCACGGTGCCACCGCTTTGTTGTGCTACACTCAATTA ATTGGTCGTACTTCTGTTGAATGGGTAGTTATCCTACTAAACTTGGGTGTTCACGTTATC ATGTACTGGTACTACTTCTTGAGTTCATGTGGTATTAGAGTTTGGTGGAAGCAATGGGTC ACTAGATTCCAAATTATTCAATTTTTGATTGACTTGGTATTTGTTTACTTTGCTACCTAT ACATTCTATGCTCACAAATACTTGGACGGTATTTTACCAAACAAGGGTACTTGTTATGGT ACTCAGGCTGCTGCTGCTTATGGGTATTTGATTCTAACATCTTATTTGCTTTTGTTTATT TCCTTCTACATCCAATCTTACAAGAAAGGTGGTAAAAAGACAGTCAAGAAGGAATCTGAA GTTTCCGGCTCCGTTGCATCCGGTTCTTCTACTGGTGTCAAGACCTCTAACACCAAGGTC TCTTCCAGGAAAGCTTAA
Protein Properties
Pfam Domain Function
Protein Residues345
Protein Molecular Weight39465.0
Protein Theoretical pI9.63
Signalling Regions
  • None
Transmembrane Regions
  • 74-94
  • 106-126
  • 208-228
  • 243-263
  • 284-304
Protein Sequence>Elongation of fatty acids protein 3 MNTTTSTVIAAVADQFQSLNSSSSCFLKVHVPSIENPFGIELWPIFSKVFEYFSGYPAEQ FEFIHNKTFLANGYHAVSIIIVYYIIIFGGQAILRALNASPLKFKLLFEIHNLFLTSISL VLWLLMLEQLVPMVYHNGLFWSICSKEAFAPKLVTLYYLNYLTKFVELIDTVFLVLRRKK LLFLHTYHHGATALLCYTQLIGRTSVEWVVILLNLGVHVIMYWYYFLSSCGIRVWWKQWV TRFQIIQFLIDLVFVYFATYTFYAHKYLDGILPNKGTCYGTQAAAAYGYLILTSYLLLFI SFYIQSYKKGGKKTVKKESEVSGSVASGSSTGVKTSNTKVSSRKA
References
External Links
ResourceLink
Saccharomyces Genome Database SUR4
Uniprot IDP40319
Uniprot NameELO3_YEAST
GenBank Gene IDAF011409
Genebank Protein ID3378048
General Reference
  • Silve, S., Leplatois, P., Josse, A., Dupuy, P. H., Lanau, C., Kaghad, M., Dhers, C., Picard, C., Rahier, A., Taton, M., Le Fur, G., Caput, D., Ferrara, P., Loison, G. (1996). "The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae." Mol Cell Biol 16:2719-2727.8649379
  • Garcia-Arranz, M., Maldonado, A. M., Mazon, M. J., Portillo, F. (1994). "Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation." J Biol Chem 269:18076-18082.8027068
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • David, D., Sundarababu, S., Gerst, J. E. (1998). "Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast." J Cell Biol 143:1167-1182.9832547
  • Oh, C. S., Toke, D. A., Mandala, S., Martin, C. E. (1997). "ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation." J Biol Chem 272:17376-17384.9211877
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956