High osmolarity signaling protein SHO1 (P40073)

Identification
NameHigh osmolarity signaling protein SHO1
Synonyms
  • Osmosensor SHO1
  • Suppressor of SUA8-1 mutation
  • Synthetic high osmolarity-sensitive protein 1
Gene NameSHO1
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction involved in filamentous growth
Specific FunctionPlasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: low osmolarityPW002515 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
integral component of membrane
cellular bud neck
mating projection tip
signal transduction involved in filamentous growth
MAP-kinase scaffold activity
cellular response to heat
osmosensory signaling pathway
plasma membrane
establishment of cell polarity
osmosensor activity
cellular bud
HICS complex
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1104 bp ATGTCAATATCATCAAAGATAAGACCAACTCCTCGTAAACCTTCACGTATGGCTACCGAC CATTCTTTTAAAATGAAAAAATTTTATGCCGATCCTTTCGCTATATCATCAATTTCTTTG GCAATTGTATCGTGGGTCATCGCCATCGGGGGCTCCATCTCATCTGCATCCACCAATGAA TCCTTCCCACGTTTTACTTGGTGGGGTATAGTATACCAATTTCTAATTATTTGTTCTTTA ATGCTGTTCTATTGTTTTGATTTAGTCGATCATTACAGAATCTTCATCACCACATCTATT GCAGTGGCATTTGTGTATAATACAAACAGTGCAACGAATTTAGTGTATGCGGATGGTCCC AAGAAAGCTGCTGCTTCAGCAGGTGTCATCTTACTTTCCATCATAAATTTAATCTGGATT CTGTACTACGGCGGTGATAATGCTTCCCCAACCAATAGATGGATTGATTCGTTTTCCATT AAGGGTATCAGGCCTTCGCCATTAGAGAATTCTCTTCATAGAGCTCGTCGAAGAGGCAAT AGGAACACAACGCCTTACCAAAATAATGTCTATAATGATGCTATACGAGACTCAGGCTAC GCGACACAGTTTGATGGATATCCACAGCAGCAACCTTCTCACACAAATTATGTATCTTCT ACGGCATTGGCTGGTTTTGAGAATACTCAGCCAAATACTTCAGAAGCCGTTAATCTTCAC TTGAACACTCTACAACAACGTATCAATAGCGCAAGCAACGCGAAGGAAACCAATGATAAT AGCAATAATCAAACCAATACTAATATAGGTAATACGTTCGATACTGATTTTTCAAATGGC AATACGGAAACTACGATGGGAGACACTTTGGGTCTGTATAGCGATATCGGTGATGATAAT TTCATTTACAAGGCAAAAGCACTGTACCCATACGACGCTGATGACGATGATGCTTACGAA ATCTCATTTGAACAAAATGAAATCCTACAAGTCTCTGACATTGAAGGCAGATGGTGGAAG GCAAGAAGGGCAAACGGTGAAACAGGTATTATTCCAAGCAATTATGTTCAACTAATCGAT GGTCCAGAAGAAATGCATCGTTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues367
Protein Molecular Weight41125.22
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane Regions
  • 33-53
  • 66-86
  • 94-114
  • 123-143
Protein Sequence>High osmolarity signaling protein SHO1 MSISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSWVIAIGGSISSASTNE SFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNLVYADGP KKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHRARRRGN RNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPNTSEAVNLH LNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGNTETTMGDTLGLYSDIGDDN FIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLID GPEEMHR
References
External Links
ResourceLink
Saccharomyces Genome Database SHO1
Uniprot IDP40073
Uniprot NameSHO1
PDB ID
2VKN
General ReferenceNot Available