GTPase-activating protein BEM2/IPL2 (P39960)

Identification
NameGTPase-activating protein BEM2/IPL2
Synonyms
  • Bud emergence protein 2
Gene NameBEM2
Enzyme ClassNot Available
Biological Properties
General Functionsmall GTPase mediated signal transduction
Specific FunctionGTPase-activating protein (GAP) for RHO1 and RHO2. Involved in the control of cellular morphogenesis. Required for proper bud site selection and bud emergence.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
cellular bud tip
incipient cellular bud site
mating projection tip
actin cytoskeleton organization
small GTPase mediated signal transduction
plasma membrane
cell cortex
GTPase activator activity
negative regulation of Rho protein signal transduction
establishment of cell polarity
guanyl-nucleotide exchange factor activity
cytoplasm
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>6504 bp ATGAAAGGTCTTCTCTGGTCTAAGAACAGGAAATCTTCAACGGCCAGTGCTAGTTCAAGC TCAACTTCCACGTCTCATAAGACAACTACTGCGTCTACAGCATCGTCGTCGTCGCCGTCA TCATCCTCTCAAACTATTCGAAACTCGACAAGCGGTGCTTCTCCATACATGCATTCCCAC CATCACCATGGCCAGGGACACAGTCACCACAGAGGGGAAGACAACAACAGAGATAAGAGA AAAAGCTCCGTATTTCCACCCTCCAAGCAGTACACATCCACTAGTTCCAGTCAGGTGAAC TTGGGGATGTATCATTCGGATACTAACACCAGATCTTCTAGAAGCATAGCCTCTACGCTA AAAGACGATTCTCCGTCTGTCTGCTCCGAAGATGAAATAAGCAATTCTTCTAGCCAGAAG TCCAATGCCCAGGATGAGACTCCCATTGCGTACAAGAAGAGTGCCCATTCGAAAGACTCA TTGTTGCCTTCACGTTCCTCGTCTTTATCACCTCCTCAGTCTCGATGTAGCACTGGAACT ACGCTAGAGAAATCGTTGAACACTTCAGGTATCAGTAACAGTAGCGGCACTAATAATAAC AATAGCAATAATAACAACGATAACGAGCAAAAGCAAAGAAATGTTATCCACTTAAACTCT GAAAACTATGATACAACTGTTTTTAAGACTGGATGGGTTAATAAGTCCCATGGCCAGACT GTTGCTACAAACTATAATAGCTCAATGACAGCCCCTTCCTCTTCCTCTTCGTCCTCCTCT CAGAATCTCCGTAATGATGCGTATTCTAGAAACAGGGAAAGCAGGTTTTATGGGAACGAC GGTTCGTCTTTAAAAAATGATGACAGCAGTAGTACTACGGCCACTAACAGTGGCAATGAT GTGGCCTCAGCAAGAAGCAGCATGGCTATAGATCCTCAAATGCTAGTACCTGATTACCGT CTTTATAGGGCTCAATTGAAAGGTTGCGTTCTCAACCTTTACAAAAGTGGTTTGAATAGT AACATTAAGTTTTTTGATCCAACTTTACCAGCTTCAAATAGTAGTATAGCAAATGAAAAC CATCAACAGAAAAAACAACAAACAAACAACCAAGCACAAGCGGAAGCTCTGCACCAAAAG CAATCATTTGGCCAAATGGGTGAACCTATTACACTGGACCTGAAGTATTTATCTGAAGTT TACCCGCACCCAGATTTAAGACAAGACAGTGATGGTAAAATTATATCAGGCACAATAGAA AGTTTATGTCACACAGTCTTATTTTACCCCGGTCCAAAGCAATCGGACGTACCTAATGAG AAATCATTATCTAAGACACATAGAGCTGTTATTAATCTGTTATTGATGTTTCCATTACTA GATCATTTCATTAAGTTTCTAAAGGTATTCAACCAATTCGGTCTTTCTTTTACCAAGAAT AAATCAAGATTGACAAATAATTCCACACAATTCTACAACATATCCCCTGCTGTCGATGAC TCCATGACTCAAAGATTAGCTTTAACTGCTAAAACAATCCTTGATGTATTTCCGGGATTT TTGCTGGATGAACCAATGCTGAAGACTATAATTTCCTTATTAGATACTATATCTTTGCAT AACGATGAAATTTCCAACAATTTGAAAATTAAAATCGCCAATAAACATAACGAATTAATG AAACTTACCGCATTCACTCGATCTCTTCCAATGGCAACATCATCTACACATGAATTAGAG ATTATATTGGATCCAAGTCATTTCCTGTCTTTAGACATTACAACATTGGCTGATGAAGTT CATCATATCAATTTAAAGTTTGATAAAGTATGGGCACCGAAATTTGACTATTCTCTGCTG TATGATTCGAAGTTTATTAATCGAAGAATTGTCTCGTTAAATCCATTGGTATTCAACAAC GACCAAAATATCCATTTTCTTGGAAGGCTACTAATATCACATTTATTTCCAACAAATCCT GAGTTTAGTAAAAAAGTGACTCCAAAAGTGAGAGCTGAGTTATTAGATAAATGGGTCCAA ATTGGCTGTAGATTTGAACATTTAGGAGACATGGTATCATGGCTAGCTGTCGCCACTATC ATTTGTTCAATTCCTGTACTAAGGTCATCTTCATGGAAATATGTTCCTGATCAGTCATTG AAAACTATTTTTAAAGATTGGGTTCCTACCATTATTCAGTTAGAGAGGCGACAAAGGACA TCTAAATCTACAAGTAGTGTTTTCATACTCGCTCCTCCAAATCTGGATGACGACTTTACG AGAGCTAACGTGATTTCTTATTTTGGCGATTTATTAATTCATGCTGATGATTTACCATCT GATACGAAATTCAAGTACTTGGAAAAGAAAATTAACAGAACAAAAAACGCTTTTCATAAA TGGCAACAAAGATTACAAGCAATCGACTCTACGAGACATAAAACTAATTCGACAGAAAAC GTCAGGGATAATGATTCTCCTAATAACGTTGTTTATCAGCTCTGGAAATTTCATTTATCA CAACCTCCGTTGAACATTGAAGGAATAATGAAATTAAGTGTCCAACACGAACCTCCAATA ATCGACCAGAAAGCGTATTCTACTATTGGTTCTCAAAGGAGTGCTTTAGTAACTGGAAGT TATTTACCCATTTTATTCAATGAACTATTCCCAAATTATTCACTATTTCCTAAGAATACA TTAGTGGGTGCTGCCAGTGATGCGAAGTTGCCGCCTCCAAGATCATCCGCGCGCCTCTCA AAATCACTTTCAATCAGTGAACCAATTCCAATAGCTTCAAACAGTCACACTATGGGCTCA TTAACAGATGATGCTATGTCCTCAAAAAATGATAATAATAAAGTTACAGGTGTTGGAAAA ATTGACGGACCTGTGATCAAAGAGATGTCGTCAAAACAATCAAATAAACAGAGACTATTA AAATCTGTGAGAGATGTTTTTAATATTGACATGGATGTGTTTCATATATCAGATGAGTTA GTATTTAAATCGGTATACGATAATGATGGTAAATCCCGTCCTGCTAGTATGGTCATAGAA ACACCAAAGAGATTCTCACAACACTCTTCCATGCTTATTAATAATCCAGCTACTCCAAAC CAAAAGATGAGAGATTCCTTGGATACCACTGGAAGACTAAGTAAGACATTAGAAAATATG GACTTTTTCAACAATATTGGTCAAGTATCAGATTCACTAAAAGAATCGATTATTCGTGTC GTATTGAAATCGTCGTCGCTAGAAAAGATTTTTGATTTACTGGTATTAACTTCAAATATC TTTTCAAAATTGGTAGACACTAAAGACCTTGAGAATTATTACTATCATCAAAGACAAAGG GGTCATTCTACCAGAGGGCTTTCCGATGATAACATAGGACTACTAGATTATGCATTCGTT AAACTAACTATGGACAATGATATTTTCACAGAAACATTCTTCAACACTTATAAAAGCTTT ACTACTACAACTACGGTATTAGAAAATATGGCAAAACGGTATGTTGGTGCAAAGAGTTGC AGCGTGTCAATTTCCAAGATTTTAGATCGCAGTGATGATTCTAAAATGAAGATAAATGAG GATACAAATTTAGTGTCCTCTTCATTATACGACCAAAATTTTCCTGTTTGGGATATGAAA GTAACTGACGATGAAAACATAAACCTTATTTATATGGCAAAAATCCAAATCGGCGCCGCG GAAGCTATACTACATTTAGTGAAAAATCATTACTCTGACTTTACTGACGATTTATGTAAC AACTCTACTCTATTGGATATTATAAAAATAATGGAACAAGAAGTATCCACTGAATGGCCT ACGCGAATTGCAAACTCAAAGTTACAAAAAAGCCTACCAGAAAATTTTGTGATTGAAACA GAAAATTTGTTGACTACGTTAACTGATCTATTTCATGGTATTAAATCAGCATACCAAAAG CAACTATACAGACCTATTGGTGTCAATAGAACTCAGAAGAGAATAACTGACATTTTGAAT TCCTTTAACACATTCTCTTTTACAGATCTTAACAACATCATTGATGATCCTTCCTTTAGC GATGACATGATTAGATCTTTTCAAAAGTTACACTCAACCAATTACGAAGATATACTAGAA TGGATCTACCAGTTAGATAACTTTATTTCTAAGAAGTTCAATTTAGTTTCTAAGAAAGAT TGGATAGTTCTTTTCCAGGAGTTGGAATTGCTTTCAAAGGAATCTCTGGTCTCTTTTTTC AATTATCCGCTACATTTTAAGTCAAGCAAATTGATAAACCCCGGATATTTGCAATTGCAC GAGTTTGAAATTTCCAATCTTTTTACTTGGATTTCTACATTGATTCTTAAGGATGATAAT GGTACGGAGAGTCTTTTTTTTGAAAAACTACCACAATCTATAAAATTGTTAATAAAGTTA CACACGAGTCTAACTACGTTTTTCGTGATGGAAATTTCAAACGTCAACAAAAGCAGTAGT GAAAGGTTAACTACTTGTAAAGTTATATTACAAATTTTGAACTACATCCGCTGGAAAAAC GGAAGTTTGGATTTATTTGATTCAGAGGAGGATGAAAGTCCTCATGCTATTTGTCCACAC ATTCCAGCTTTTATTGAAACTGCTATTGCGCATGCCATAATATCACCAGAGTCTAGAAAC TATGAACTTTCGTGGATCAAAGCTTCTGAAAAACTTTCGGACCCTACTAAAGGAACCCAA AATCTAAGATCGATTAGTAACGTTTTAGAGAAGATAGATGACATACATATAAAGAGATTC ATTGAGATTGATGATGTATTCAGCAAAAACTGCAAGAATTTATGCCCCTGCCCTGGTTGG TTCATTTCAAGGTTACTAGAAATATCTCAGTTTGTCCCTAACATGAGTATCACTAATTCG AAACTTATTAATTTTGACAAAAGGAGATTTGTTAACAACATAATATCTAATGTCTTGGAT TTAATTCCGAACGAAAGGGAGTTTCCACTTGATATTGAAATGAGTGACGAAAATCCTTCG AAAAGAACTACATTTGGCCGCATTCTGTTCAATAATTTTGAAGATGTTAATAAAGTATAC AGAAAGAAGACTAAAAAAGTATCAGAATCAGAAGCCATATCGGAGAGATTTCAAGAGCAG GGAGTATTTAATGAAATACTAGTCAATGAAATTGAAAAAATAAAGAGGGAAGCCAGAAAA TTAGAGGTTTTACTCGATCAAGAAAAGATCTTGAAGAACTCTGCTGCTTTACATCAGGCC GTTCCGAAAAAGAATAGGAAGTCTGTTATTATCTCAGGTACTCATAGTGACAACGATCAT AGCTATAATATCAATAAGAACACCGGTCAAACGCCTTCTCTAGGTAGTGTTATGGAAAGC AATAATTCAGCAAGGAATAGAAGAGATTCAAGGGCCTCCTTTTCCACAAATAGATCATCA GTAGTGTCAAATTCCAGCCATAATGGTGTTAGTAAAAAAATAGGTGGATTTTTCAGAAGA CCATTTTCAATCGGTGGATTCAACACATCCAGTTCTAATTATTCACTCAACAGTATATTA TCGCAAGAAGTTTCAAGTAACAAATCCATTCTACCAAGTATACTTCCAGAGGTTGATTCC ATGCAACTACACGACTTAAAACCTAGTTATAGTTTGAAGACCTTTGAAATCAAGTCAATA ATGGAAATAATCAATCACAGAAACATTCCGGCTTACTACTATGCGTTCAAGATAGTTATG CAAAATGGCCATGAATATCTGATTCAAACGGCTAGTTCTAGTGACCTCACAGAATGGATA AAAATGATCAAGGCTTCCAAGAGATTTTCATTCCATTCGAAAAAATATAAAGGTAAAACT CATAATAAGATATTTGGGGTACCATTAGAAGACGTTTGTGAAAGAGAGAATACCTTGATA CCTACAATTGTTGTGAAATTGCTGGAAGAGATTGAGCTGCGTGGGCTAGATGAAGTGGGA TTGTACAGAATTCCTGGTTCCATCGGCAGTATAAATGCACTAAAGAACGCATTTGACGAA GAAGGTGCAACAGATAATTCCTTTACATTAGAGGACGATAGATGGTTTGAAGTGAATGCG ATCGCAGGCTGTTTTAAGATGTATTTAAGAGAGTTACCAGATTCTTTATTTTCTCATGCT ATGGTGAACGACTTTACCGATTTGGCGATTAAGTATAAAGCACATGCAATGGTAAATGAA GAATACAAGAGAATGATGAATGAGTTACTCCAAAAGTTACCTACATGCTATTACCAAACT TTGAAAAGAATTGTATTTCATTTGAATAAAGTACATCAGCATGTTGTAAATAATAAAATG GACGCATCAAACTTGGCTATTGTATTTTCCATGAGTTTTATAAACCAAGAAGACTTAGCC AACAGCATGGGGTCCAGATTAGGTGCAGTTCAGACAATCCTGCAAGATTTTATTAAGAAT CCAAATGATTATTTCAAGCAATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues2167
Protein Molecular Weight245427.8
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>GTPase-activating protein BEM2/IPL2 MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQTIRNSTSGASPYMHSH HHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIASTL KDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGT TLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSENYDTTVFKTGWVNKSHGQT VATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGND VASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANEN HQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSEVYPHPDLRQDSDGKIISGTIE SLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFPLLDHFIKFLKVFNQFGLSFTKN KSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVFPGFLLDEPMLKTIISLLDTISLH NDEISNNLKIKIANKHNELMKLTAFTRSLPMATSSTHELEIILDPSHFLSLDITTLADEV HHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPLVFNNDQNIHFLGRLLISHLFPTNP EFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWLAVATIICSIPVLRSSSWKYVPDQSL KTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPNLDDDFTRANVISYFGDLLIHADDLPS DTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHKTNSTENVRDNDSPNNVVYQLWKFHLS QPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRSALVTGSYLPILFNELFPNYSLFPKNT LVGAASDAKLPPPRSSARLSKSLSISEPIPIASNSHTMGSLTDDAMSSKNDNNKVTGVGK IDGPVIKEMSSKQSNKQRLLKSVRDVFNIDMDVFHISDELVFKSVYDNDGKSRPASMVIE TPKRFSQHSSMLINNPATPNQKMRDSLDTTGRLSKTLENMDFFNNIGQVSDSLKESIIRV VLKSSSLEKIFDLLVLTSNIFSKLVDTKDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFV KLTMDNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISKILDRSDDSKMKINE DTNLVSSSLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCN NSTLLDIIKIMEQEVSTEWPTRIANSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQK QLYRPIGVNRTQKRITDILNSFNTFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILE WIYQLDNFISKKFNLVSKKDWIVLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLH EFEISNLFTWISTLILKDDNGTESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSS ERLTTCKVILQILNYIRWKNGSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRN YELSWIKASEKLSDPTKGTQNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGW FISRLLEISQFVPNMSITNSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPS KRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARK LEVLLDQEKILKNSAALHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMES NNSARNRRDSRASFSTNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSIL SQEVSSNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVM QNGHEYLIQTASSSDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLI PTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNA IAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQT LKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQDFIKN PNDYFKQ
References
External Links
ResourceLink
Saccharomyces Genome Database BEM2
Uniprot IDP39960
Uniprot NameBEM2
General ReferenceNot Available