Glycine cleavage system H protein, mitochondrial (P39726)

Identification
NameGlycine cleavage system H protein, mitochondrial
Synonyms
  • Glycine decarboxylase complex subunit H
Gene NameGCV3
Enzyme ClassNot Available
Biological Properties
General FunctionAmino acid transport and metabolism
Specific FunctionThe glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
glycine cleavage complex
macromolecular complex
protein complex
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
mitochondrion
Process
glycine decarboxylation via glycine cleavage system
serine family amino acid metabolic process
glycine metabolic process
glycine catabolic process
metabolic process
cellular metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>534 bp ATGAAGCATACCACATCGACAATGTTACGCACTACTAGACTATGGACCACCCGCATGCCC GCTGTGAGCAAATTGTTTTTGAGAAACAGCTCCGGCAATGCCCTAAACAAGAATAAACTA CCATTTTTGTACTCATCCCAAGGACCTCAAGCCGTGAGGTACACTTCCCAACATGAGTGG ATAGCTGTGCATCAGGACAAGACTGCCTTTGTCGGAATTACAAAATACGCCACTGATTCC TTAGGGGACGCTACCTATGTTGAGTTGCCAGAAGTGGGCACTGAGATTTCCCAAGGTGAG TCGCTAGGGTCCATTGAGTCCGTCAAGTCAGCCTCCGAGATCTACCAGCCTGCCGATGGT ACCGTAGAGGAAATTAACACTAATCTTGAGGAAAATCCAGGTGTGGTGAACGAAGATCCT ATGGGTGACGGCTGGCTAGTCAAAATGAAGCTTGGTGAGGGCGTTAATGTGGAACAGGTC GAGGGTCTAATGTCCTTAGAACAGTACGAAAAGACACTGGTTCATGATGACTGA
Protein Properties
Pfam Domain Function
Protein Residues170
Protein Molecular Weight18794.90039
Protein Theoretical pI4.38
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Glycine cleavage system H protein, mitochondrial MLRTTRLWTTRMPAVSKLFLRNSSGNALNKNKLPFLYSSQGPQAVRYTSQHEWIAVHQDK TAFVGITKYATDSLGDATYVELPEVGTEISQGESLGSIESVKSASEIYQPADGTVEEINT NLEENPGVVNEDPMGDGWLVKMKLGEGVNVEQVEGLMSLEQYEKTLVHDD
References
External Links
ResourceLink
Saccharomyces Genome Database GCV3
Uniprot IDP39726
Uniprot NameGCSH_YEAST
GenBank Gene IDU12980
Genebank Protein ID595540
General Reference
  • Bussey, H., Kaback, D. B., Zhong, W., Vo, D. T., Clark, M. W., Fortin, N., Hall, J., Ouellette, B. F., Keng, T., Barton, A. B., et, a. l. .. (1995). "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A 92:3809-3813.7731988
  • Nagarajan, L., Storms, R. K. (1997). "Molecular characterization of GCV3, the Saccharomyces cerevisiae gene coding for the glycine cleavage system hydrogen carrier protein." J Biol Chem 272:4444-4450.9020168
  • Kellis, M., Patterson, N., Endrizzi, M., Birren, B., Lander, E. S. (2003). "Sequencing and comparison of yeast species to identify genes and regulatory elements." Nature 423:241-254.12748633
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956