Rho-type GTPase-activating protein 1 (P39083)

Identification
NameRho-type GTPase-activating protein 1
SynonymsNot Available
Gene NameRGA1
Enzyme ClassNot Available
Biological Properties
General Functionseptin ring organization
Specific FunctionGTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
cellular bud neck split septin rings
zinc ion binding
pheromone-dependent signal transduction involved in conjugation with cellular fusion
invasive growth in response to glucose limitation
pseudohyphal growth
actin filament organization
septin ring organization
GTPase activator activity
budding cell apical bud growth
budding cell isotropic bud growth
establishment of cell polarity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>3024 bp ATGGCATCAACTGCTCCCAATGAACAATTTCCATCCTGCGTACGATGCAAAGAATTTATT ACCACGGGGCATGCATATGAGTTGGGTTGTGATAGATGGCACACACATTGTTTCGCTTGT TACAAATGTGAGAAACCATTAAGCTGCGAATCTGATTTTTTAGTCCTTGGAACAGGTGCT TTGATCTGCTTTGATTGTTCCGATTCTTGTAAAAATTGCGGTAAAAAGATTGATGATTTG GCCATAATACTGTCCTCTTCAAATGAGGCCTATTGTTCAGATTGTTTTAAATGCTGTAAA TGTGGTGAAAATATTGCTGACCTACGGTACGCGAAAACCAAGCGAGGTTTATTCTGTTTA AGCTGTCACGAAAAGCTATTAGCCAAACGAAAATACTACGAAGAGAAGAAAAGGCGACTC AAAAAGAATTTACCAAGTTTACCCACACCTGTGATTGATAATGGCCATACTGATGAGGTC TCAGCTTCTGCAGTCCTCCCAGAAAAAACATTTAGCAGACCTGCATCACTAGTTAATGAG ATTCCTTCAGGTTCTGAACCTTCCAAGGACATAGAAACCAATTCGAGTGATATTGTTCCG CATTTTATCACTGGGTATAACGATAGCGATGACAACTCTGGAAGTTCAAAATTCGGTTCA AATGTGTCCATAGATGTTATAGGACCGGAAGAAAATAGCACGGAGCATGTAAATGATGAT GTTAAAGAGGAAGCAGAAGCACCTTCAGCGAATATGTCACTCAATGTTGCTACGGATCCA ACCCTAAGTTGTAAAGAACCTCCTAGCCATTCGAGGAATTTGTTAAATAAAACACCGTTG AGAAATTCTTCGGGTCAGTATCTCGCAAAATCTCCAAGCTCCTATAGACAGGGAATAATT GTTAACGATAGTCTGGAAGAGAGCGATCAAATTGATCCTCCAAATAACAGTTCACGAAAT GCAAGTGAATTGTTGACCTCGGTATTGCATAGCCCAGTTTCTGTTAATATGAAAAATCCG AAGGGTTCAAATACGGATATTTTCAACACCGGTGAAATATCCCAAATGGATCCTTCGCTA TCAAGGAAAGTATTGAATAATATTGTCGAAGAAACAAACGCACTTCAAAGGCCAGTTGTT GAAGTTGTCAAGGAAGACAGAAGTGTTCCTGACCTAGCAGGTGTTCAGCAAGAGCAAGCA GAGAAATATTCCTATTCAAACAATAGTGGAAAAGGCAGAAAAATTTCAAGATCATTGTCA CGAAGGTCCAAAGATTTGATGATTAATCTAAAATCCAGAGCCACAGGCAAACAGGATAGT AACGTTAAACTTTCACCTGCTTCTAAAGTGACATCTAGACGCTCACAAGATTTAATGAGG GATAATGATTCACATACCGGCCTTGACACACCAAATTCTAACAGCACTTCTTTAGATATT TTGGTGAATAATCAAAAAAGCCTAAACTATAAAAGATTTACCGATAATGGCACTCTTAGG GTGACTAGTGGAAAGGAAACCGCCCTTGAAGAACAGAAGAATCACAGTTTTAAATCTCCG TCACCAATTGATCATTTGTTACAATCGCCAGCTACACCAAGTAATGTATCCATGTATCGA ACTCCGCCTTTAGATAGCTCATTGACATTTGATAGGCGGAATGGGTCTTCATACAGTAAC CAAAATTATAGCATACCTAGTTGGCAGAAAACTCCAAAGACCCAATTGGAGAATAGCGAC AATTTTGAGGAACAGAAGGAAACACTTTACGAAAATAGCGAATCTAGAAACGATCCCTCG CTTGATAAAGAAATTGTCACGGCAGAGCACTATCTGAAGCAATTAAAAATAAATTTGAAA GAACTTGAATCTCAAAGGGAAGAATTAATGAAAGAGATCACTGAAATGAAGTCTATGAAA GAGGCTCTACGCCGACATATTGAATCCTATAATAGCGAGAAAAATAAACTATATCTTGAC TCCAATGAATTATCAAATAATCCACCGATGATAAATGAAATCAGCTTAGGTGAGTCGCCA CCCGTGAAACATGTTGCAACTGCAAGTTCTGTAGCGCGAAGTTCTGTTAAACCAAAATTT TGGAAGTTTTTTTCATCTGCAAAGCCACAGACCGAGCAATCTATACAAGGTGTCAGTACA AATAATACAAATTCCATCGTTAAAAGTGCCCCAGTTTTGCTTTCTGCTCCCTCATCTGGT AGTAATTCCGGCCGTTTAGAAATTTCACCACCTGTGCTACAAAATCCTAATGAATTTAGT GACGTTAGATTAGTACCTATCGAGAACGATGCAAATATGGGACAAAGTAAAGATGGAGAA GAATATTTGGATGGAAGCAATTTGTATGGTTCAAGTCTCGTTGCTAGGTGCAATTATGAA AACAATGAAATACCGATGATACTATCTGTCTGCATAGATTTTATTGAATCAGACGAAGAA AATATGAGATCGGAGGGCATTTATAGAAAATCAGGTTCCCAGCTAGTCATAGAAGAAATA GAAAAGCAATTTTCTGCATGGAAAGTACAACAAAATACCGAAACGCCAAATATTTTAACG GAACAAGATCTCAACGTTGTTACTGGTGTGTTGAAGCGATACTTAAGAAAGCTCCCCAAC CCTATCTTTACCTTTCAAATATACGAGCCGTTGATGAGGTTAGTTAAATCTAAAAAAATG ATGGAAAACTTGCCATTTGTTGGAGGAAAGTTGTCCTTAGAAGCAAAGAATTCGGACACT TATATGTCGAGCAAGAGCGCTTTAAAAAACATATTGGAAGACCTTCCAAGGGAACATTAT AGGGTGTTAAGAGTACTGAGTGAACATATAGAAAAGGTTACACGGTACAGTCACTGGAAT CGAATGACGCTTTATAATTTGGCTTTAGTTTTTGCTCCAGGTTTGATTCGTGATTTCAGT GGAGAAAAGGATATTATTGATATGAAAGAAAGAAACTATATTGTCGCATTTATATTTGGG AACTACAAAGATATCCTGACGTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1007
Protein Molecular Weight112830.39
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Rho-type GTPase-activating protein 1 MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGA LICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCL SCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNE IPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDD VKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGII VNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSL SRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLS RRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDI LVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYR TPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPS LDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLD SNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVST NNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGE EYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEI EKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKM MENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWN RMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT
References
External Links
ResourceLink
Saccharomyces Genome Database RGA1
Uniprot IDP39083
Uniprot NameRGA1
General ReferenceNot Available