Histone-lysine N-methyltransferase, H3 lysine-4 specific (P38827)

Identification
NameHistone-lysine N-methyltransferase, H3 lysine-4 specific
Synonyms
  • COMPASS component SET1
  • Lysine N-methyltransferase 2
  • SET domain-containing protein 1
Gene NameSET1
Enzyme Class
Biological Properties
General FunctionInvolved in histone-lysine N-methyltransferase activity
Specific FunctionCatalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation
Cellular LocationNucleus (Probable). Chromosome (Probable)
SMPDB PathwaysNot Available
KEGG Pathways
Lysine degradationec00310 Map00310
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00438S-Adenosyl-L-methionineShow
GO Classification
Component
macromolecular complex
protein complex
chromatin remodeling complex
Set1C/COMPASS complex
Function
methyltransferase activity
binding
protein binding
protein methyltransferase activity
protein-lysine N-methyltransferase activity
histone-lysine N-methyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular process
cellular component organization at cellular level
organelle organization
chromosome organization
chromatin organization
chromatin modification
Gene Properties
Chromosome Locationchromosome 8
LocusYHR119W
Gene Sequence>3243 bp ATGACGACGAAGCCACAAAATAGTAAGCAGGGTTTAGCCGAAGGAGAGATGGATGTGAGT TCACTTTTCAAGAGAACGGAAGTTATTGGGCGAGGGAAATTTGGTGTGGTTTATAAGGGC TATAACGTGAAGACTGGACGAGTGTATGCTATCAAAGTCTTAAATTTAGATTCTGATTCT GACGAGGTGGAGGATGTGCAGCGAGAAATTCAGTTTTTGGCCTCCTTGAAACAGATTTCC AATATCACGCGGTATTATGGGTCGTATTTGAAAGACACAAGCCTTTGGATCATAATGGAA CACTGCGCTGGTGGTTCACTGCGTTCGTTGTTAAGGCCAGGCAAAATCGATGAAAAGTAC ATTGGGGTTATTATGAGAGAACTGCTTGTAGCATTAAAATGCATTCATAAAGATAACGTC ATTCATCGAGATATCAAAGCAGCAAACGTTCTGATCACTAACGAAGGTAATGTTAAACTA TGCGATTTTGGTGTCGCTGCACAAGTAAACCAAACTTCTTTACGACGTCAAACTATGGCT GGGACCCCCTACTGGATGGCTCCAGAAGTGATCATGGAAGGCGTTTATTACGACACTAAA GTAGATATATGGTCTTTAGGTATTACAACGTACGAGATTGCCACCGGAAATCCGCCATAC TGCGATGTGGAGGCCCTAAGGGCAATGCAACTAATCATCAAATCGAAACCACCGAGGCTT GAGGACAGATCATACAGTACATCTTTGAAAGAATTTATTGCGCTTTGTCTTGATGAGGAT CCAAAGGAGAGATTGTCAGCAGACGATCTTTTAAAATCAAAATTTATCAGGGCCCACAAG GCGACGCCAACGTCCATTTTGAAAGAACTAATATCACGATATCTACTATTTAGGGACAAG AATAAAAACAAATATAAAATAGAGGGCAGTATACCGGAAAATGAGCCATCAAAACCCAGT GAAGCTCCAAAACCATCACAAAATGGCGGGGGTGATGAAGCACAAAAGTCAATAGCATCA AATGATAATGAAATTAAGAGAGTGAACGAAGGCGATGTGGAAATGAAATGGGATTTTGAT TCATTGAGTTCGTCGGATTATATTATTGAAAATAATATCAACCTCGATGCTTTGGCTGAG GACAACAACGAGTGGGCTACTGCCCAACATGACCTGTTCAACTATGCATACCCTGACGAA GATTCTTATTACTTTGACCCTACAAGTCATAATACTAGACCCTTTGTTTATCAAGGGACA ACGATAGGAAAGGGCTATCCTGGTACAATAGCTCAAAATTCTACTTTGAATGCACCAGTA ACAAATAACTATACGAACTCAAAATACCCTTCCAAAATGGTAGCTGGAACTACAAACACC TCTGGAACACATACGGCCGGTCCAATGACATCATCTAAGAGGCTGGAAAGTAAGGCTCCA AAACAATTACTTGAACTTTTTGAAGACAATGAAATTATTACTGCTGAAAATGATGTCAAT ACAGAAGCTCCTAAAATAAGCAAATCCATTTCATCTCTAAATGCTGGTAATAGTTCACGA GATGATTTCATTCCCTCAATATCCAACGAGGTCAACGGAAATATCAATAATAATAAAATG CGACCACACCTTCCACCTTTATCCAGTGGGAACAATTATTATAGCCAGAGTACACCTGCT TTGCCGCTACTCCAAACAAAATTTAACAAGACGTCAAAGGGCCCTCCAACAAGTGGATTA ACTACTGCTCCAACGTCTATTGAAATAGAAATTCCTGAAGAACTACCGAATAGTGCTCTA CCAACGCCTGCGAGCGCAGATCCGGTTTTAATACCAAGCACAAAGGCCAGGTCATCTACA GTGACGGCTGGCACTCCTTCGTCATCTAGCTCAATACAATATAAATCACCTTCAAACGTG CCCAGGCGGTTGACAGTCAGTAACAATAGGCCAGAACATTGCCCAAGCACCATAACAAAT CAAAAATTGGGGTCCGCAGTTGCTTCTAATTCCGGAATCAGCTCCACTCCGAACAACAGT AATAACTATAACAACAACACTGATAGTGAGAACTCAAGAGGAAGCAGCGGTAGTAACACT GCAAATAGCACACAAATGGGCATAACCAATCCAGGTAATGTAACAAAGTTATCTACTCAT AAGGCTTCTTCACCCTCAAGGCCACTATTTGGAGTTGGAACTTCTCCCAATAGAAAGCCT GCCGGTTCCCCAACCCAAAACATTGGTCATAATTCTACTCACACGAACCTCGCGCCTCCT CCTACGATGAAACCAATGGCCAATAGCAAAGATAACAAGGACATTCTCTTGCAACCTCTG AACAGCATACCTAGTTCTTCTACACTTAACACTATTAGTGGTAATAGCAGCAATAATTTA ACCTCATCAAACTACTTTTCCAACGAAAAGGAAGGCTCAAGGGTCAATGGTGACTTTAAA CGCAACAACCCAAACTTAAAACTACAAATGCCACTACCTACACCTGTTGTGAGAAATAAA CTTCTTGATCCAAATACAGCAACCTCACAGAATAACAATGGCATGCCGGGGAGCGCTGGC ATATCCACGAACGAAAATATTAATCAATTTGGATTTAACACAAGCAGTGCGTCCAACATC CCTGTCTCAATGACTCCAATTAGTGAGAAACACATTGATTTTGGGGGCAAGATCAAGAGA AGTCAAAGCATTTCTAACAGGAAGAACTCTTCTGCCTCGGAACACCCATTGAATATTCTT GGCTCATCTGTTTCCGGCAATGTTTCCGGTATCGGTAACAACAATGTTGGCTCTAACAAC AACAGCGGCCCTAATAACAGTGTTCCTCTTTCTGCTAATACAGGAAACACTACTATCAAA GCCAATTCTACGACTATCGCAACTTCAAGTTCTGCCGCGGCATCAACGACTGCACCAATT TCACAACAGACTATTCCATCCGGAACACAATTCAATCATATTCTGAGTTCCGCCGCAACA GCTGCAAACTCGGTTAATTCTTTAGGCTTTGGCATGTGTCCTCCTCCACAGAGTTTACAA ATGGAAATGTTCTTGGACTTAGAATCGTTTCTGCCAGGAAAACAGAGGCGGGTAGACAGG AAACCCCAGGTTCTGAAAGAACTGGAAAATCTTTTACAAATGTTCGAAGAAGGTTTGCCC TGCATTGAACACGCTTTAAAGGAACAACTTATTTCAACGCCTATCAAGGATAATGAGCAT TAA
Protein Properties
Pfam Domain Function
Protein Residues1080
Protein Molecular Weight123911.0
Protein Theoretical pI9.36
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Histone-lysine N-methyltransferase, H3 lysine-4 specific MSNYYRRAHASSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRR YNDDRPHSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSNVHNTLASSSG SLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGY YVVKELQDGQFKFKIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRY SLGPPPSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKY ASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQK LQENLKKAKEKEAENEKAKELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPV LHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTI MSRSRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDL EKTLHVDIKKRLIGPTVFDALDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAK RDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTP LNDEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPD QNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQL LSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGF RKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSS RDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAA KEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCD PNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN
References
External Links
ResourceLink
Saccharomyces Genome Database SET1
Uniprot IDP38827
Uniprot NameSET1_YEAST
GenBank Gene IDU00059
Genebank Protein ID529127
General Reference
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
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  • Morillon, A., Karabetsou, N., Nair, A., Mellor, J. (2005). "Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription." Mol Cell 18:723-734.15949446
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