Mitochondrial peroxiredoxin PRX1 (P34227)

Identification
NameMitochondrial peroxiredoxin PRX1
Synonyms
  • 1-Cys PRX
  • Mitochondrial thiol peroxidase
  • mTPx
  • Thioredoxin reductase
Gene NamePRX1
Enzyme Class
Biological Properties
General FunctionPosttranslational modification, protein turnover, chaperones
Specific FunctionHas a thioredoxin peroxidase activity with a role in reduction of hydroperoxides
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
peroxiredoxin activity
antioxidant activity
Process
cellular process
cellular homeostasis
cell redox homeostasis
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>786 bp ATGTTTAGTAGAATTTGTAGCGCTCAATTAAAGAGGACGGCATGGACCCTTCCTAAGCAG GCTCACTTGCAATCACAGACGATTAAAACATTTGCCACAGCACCTATTCTGTGCAAACAA TTCAAACAAAGTGATCAACCAAGACTAAGAATAAACTCTGATGCTCCTAACTTTGATGCT GACACAACGGTTGGTAAAATCAATTTTTACGACTACTTGGGCGACTCTTGGGGGGTCTTG TTTTCTCACCCAGCAGATTTCACCCCTGTCTGCACCACCGAAGTCAGCGCATTCGCCAAA TTGAAGCCGGAATTCGACAAGAGAAATGTTAAATTGATCGGGCTTTCAGTGGAAGATGTT GAGTCCCACGAAAAATGGATTCAAGACATCAAGGAAATAGCAAAGGTTAAAAATGTTGGT TTCCCAATAATTGGTGACACTTTTAGAAACGTGGCATTCCTATATGATATGGTAGATGCC GAAGGATTCAAAAATATCAATGATGGGTCACTGAAGACCGTGAGGTCTGTTTTCGTCATC GATCCCAAGAAGAAGATTAGACTGATTTTTACCTACCCTTCCACCGTCGGAAGAAACACT TCTGAAGTGTTAAGGGTAATCGACGCCTTGCAATTGACTGACAAGGAGGGCGTAGTAACT CCAATTAATTGGCAGCCAGCTGACGATGTCATTATTCCTCCCTCTGTCTCCAATGATGAG GCGAAGGCTAAATTTGGTCAATTTAATGAAATTAAACCCTATTTAAGATTCACCAAGTCG AAATAA
Protein Properties
Pfam Domain Function
Protein Residues261
Protein Molecular Weight29495.59961
Protein Theoretical pI9.33
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Mitochondrial peroxiredoxin PRX1 MFSRICSAQLKRTAWTLPKQAHLQSQTIKTFATAPILCKQFKQSDQPRLRINSDAPNFDA DTTVGKINFYDYLGDSWGVLFSHPADFTPVCTTEVSAFAKLKPEFDKRNVKLIGLSVEDV ESHEKWIQDIKEIAKVKNVGFPIIGDTFRNVAFLYDMVDAEGFKNINDGSLKTVRSVFVI DPKKKIRLIFTYPSTVGRNTSEVLRVIDALQLTDKEGVVTPINWQPADDVIIPPSVSNDE AKAKFGQFNEIKPYLRFTKSK
References
External Links
ResourceLink
Saccharomyces Genome Database PRX1
Uniprot IDP34227
Uniprot NamePRX1_YEAST
GenBank Gene IDZ23261
Genebank Protein ID313735
General Reference
  • Scherens, B., el Bakkoury, M., Vierendeels, F., Dubois, E., Messenguy, F. (1993). "Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes." Yeast 9:1355-1371.8154187
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Park, S. G., Cha, M. K., Jeong, W., Kim, I. H. (2000). "Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae." J Biol Chem 275:5723-5732.10681558
  • Pedrajas, J. R., Miranda-Vizuete, A., Javanmardy, N., Gustafsson, J. A., Spyrou, G. (2000). "Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity." J Biol Chem 275:16296-16301.10821871
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666