Succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial (P33421)

Identification
NameSuccinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
SynonymsNot Available
Gene NameSDH3
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionMembrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction
Cellular LocationMitochondrion inner membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
plasma membrane part
plasma membrane succinate dehydrogenase complex
cell part
membrane
membrane part
Function
catalytic activity
oxidoreductase activity
electron carrier activity
oxidoreductase activity, acting on the CH-CH group of donors
succinate dehydrogenase activity
Process
cellular metabolic process
cofactor metabolic process
coenzyme metabolic process
acetyl-CoA metabolic process
acetyl-CoA catabolic process
tricarboxylic acid cycle
metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>597 bp ATGTCTGCAATGATGGTCAAGTTAGGACTGAATAAGTCGGCTCTATTACTGAAACCCTCC GCCTTTTCAAGAGCAGCTGCCTTGAGCTCCTCGAGGAGGCTGCTTTTTAATACAGCTAGA ACAAACTTCCTTTCTACCTCACCATTGAAGAATGTGGCCAGTGAAATGAACACCAAAGCG GCAATTGCTGAAGAACAAATATTAAACAAGCAAAGAGCAAAGAGACCTATTTCTCCACAT CTGACCATTTACCAGCCACAATTAACTTGGTACCTGTCTTCTCTTCACCGTATTTCGTTG GTGCTTATGGGACTAGGTTTCTACTTGTTTACTATACTCTTCGGAGTCTCTGGTTTATTA GGTCTTGGATTGACTACCGAAAAGGTTTCTAATTGGTACCATCAGAAGTTTTCCAAGATT ACCGAATGGTCCATCAAGGGTTCCTTTGCTTACTTATTTGCAATTCACTATGGTGGCGCC ATTAGACACTTGATCTGGGATACCGCTAAGGAATTGACATTGAAAGGCGTTTACAGAACT GGTTACGCTCTCATTGGTTTCACCGCCGTCCTCGGTACTTATTTATTAACTTTATGA
Protein Properties
Pfam Domain Function
Protein Residues198
Protein Molecular Weight22067.69922
Protein Theoretical pI10.78
Signalling Regions
  • None
Transmembrane Regions
  • 100-120
  • 140-160
  • 176-196
Protein Sequence>Succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial MSAMMVKLGLNKSALLLKPSAFSRAAALSSSRRLLFNTARTNFLSTSPLKNVASEMNTKA AIAEEQILNKQRAKRPISPHLTIYQPQLTWYLSSLHRISLVLMGLGFYLFTILFGVSGLL GLGLTTEKVSNWYHQKFSKITEWSIKGSFAYLFAIHYGGAIRHLIWDTAKELTLKGVYRT GYALIGFTAVLGTYLLTL
References
External Links
ResourceLink
Saccharomyces Genome Database SDH3
Uniprot IDP33421
Uniprot NameSDH3_YEAST
GenBank Gene IDAY693024
Genebank Protein ID51013499
General Reference
  • Abraham, P. R., Mulder, A., Van 't Riet, J., Planta, R. J., Raue, H. A. (1992). "Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes." Yeast 8:227-238.1574929
  • Daignan-Fornier, B., Valens, M., Lemire, B. D., Bolotin-Fukuhara, M. (1994). "Structure and regulation of SDH3, the yeast gene encoding the cytochrome b560 subunit of respiratory complex II." J Biol Chem 269:15469-15472.8195189
  • Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Abraham, P. R., Mulder, A., van 't Riet, J., Raue, H. A. (1994). "Characterization of the Saccharomyces cerevisiae nuclear gene CYB3 encoding a cytochrome b polypeptide of respiratory complex II." Mol Gen Genet 242:708-716.8152421
  • Oyedotun, K. S., Lemire, B. D. (1999). "The Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase. Identification of Sdh3p amino acid residues involved in ubiquinone binding." J Biol Chem 274:23956-23962.10446163
  • Lemire, B. D., Oyedotun, K. S. (2002). "The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase." Biochim Biophys Acta 1553:102-116.11803020
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Oyedotun, K. S., Yau, P. F., Lemire, B. D. (2004). "Identification of the heme axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase." J Biol Chem 279:9432-9439.14672930
  • Oyedotun, K. S., Lemire, B. D. (2004). "The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies." J Biol Chem 279:9424-9431.14672929