Mannosyl phosphorylinositol ceramide synthase SUR1 (P33300)

Identification
NameMannosyl phosphorylinositol ceramide synthase SUR1
SynonymsNot Available
Gene NameSUR1
Enzyme ClassNot Available
Biological Properties
General FunctionCell wall/membrane/envelope biogenesis
Specific FunctionInvolved in the synthesis of mannosyl phosphorylinositol ceramide. Catalyzes the addition of mannosyl to phosphorylinositol ceramide. Suppressor of RVS161 mutation
Cellular LocationMembrane; Multi-pass membrane protein (Potential)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1149 bp ATGAGAAAAGAATTAAAATACCTTATCTGCTTCAACATACTCCTCCTGTTATCTATAATA TACTACACTTTCGATTTGCTAACGTTGTGTATTGACGATACTGTTAAAGATGCTATACTT GAGGAAGACTTAAATCCAGATGCACCTCCAAAGCCTCAACTAATACCTAAAATCATACAT CAGACTTATAAAACGGAAGACATCCCTGAGCACTGGAAAGAGGGTAGACAAAAATGTCTC GATCTACATCCAGATTACAAGTACATCCTATGGACGGACGAGATGGCCTATGAGTTTATA AAGGAAGAATACCCGTGGTTTCTCGATACTTTTGAGAACTACAAATACCCCATAGAACGT GCCGATGCCATTCGTTACTTTATCCTGTCCCATTATGGTGGTGTATACATCGATTTAGAT GACGGCTGCGAAAGGAAACTAGATCCTTTGTTAGCTTTCCCGGCCTTCTTAAGAAAGACT TCACCTTTAGGTGTCTCAAACGATGTCATGGGTTCTGTGCCTAGACATCCCTTCTTTTTA AAGGCTTTAAAGTCTTTGAAACACTATGACAAGTACTGGTTTATCCCTTACATGACTATT ATGGGGTCTACTGGTCCGTTGTTTTTAAGTGTTATTTGGAAGCAGTACAAAAGATGGCGC ATACCTAAGAACGGGACAGTAAGAATCCTACAACCTGCTTACTACAAGATGCATAGTTAT TCATTTTTCTCCATTACTAAAGGCTCTTCATGGCATTTAGATGATGCAAAATTGATGAAA GCACTAGAAAACCACATCTTATCCTGCGTCGTTACCGGATTTATTTTTGGCTTCTTTATC CTATATGGTGAATTCACGTTCTATTGCTGGTTGTGTTCCAAGAATTTCAGTAATCTAACC AAAAATTGGAAACTTAATGCTATAAAAGTAAGATTTGTCACAATTCTAAATTCATTAGGC TTAAGACTAAAGTTGAGTAAAAGTACCAGTGATACTGCCAGTGCCACTTTGCTGGCAAGG CAGCAGAAACGATTGAGGAAAGATTCCAATACAAACATAGTGTTACTAAAATCTTCAAGG AAAAGTGATGTTTACGATTTAGAAAAGAATGATTCTTCTAAGTACTCACTGGGAAATAAC AGCTCGTAA
Protein Properties
Pfam Domain Function
Protein Residues382
Protein Molecular Weight44807.5
Protein Theoretical pI9.28
Signalling Regions
  • None
Transmembrane Regions
  • 7-27
  • 270-290
Protein Sequence>Mannosyl phosphorylinositol ceramide synthase SUR1 MRKELKYLICFNILLLLSIIYYTFDLLTLCIDDTVKDAILEEDLNPDAPPKPQLIPKIIH QTYKTEDIPEHWKEGRQKCLDLHPDYKYILWTDEMAYEFIKEEYPWFLDTFENYKYPIER ADAIRYFILSHYGGVYIDLDDGCERKLDPLLAFPAFLRKTSPLGVSNDVMGSVPRHPFFL KALKSLKHYDKYWFIPYMTIMGSTGPLFLSVIWKQYKRWRIPKNGTVRILQPAYYKMHSY SFFSITKGSSWHLDDAKLMKALENHILSCVVTGFIFGFFILYGEFTFYCWLCSKNFSNLT KNWKLNAIKVRFVTILNSLGLRLKLSKSTSDTASATLLARQQKRLRKDSNTNIVLLKSSR KSDVYDLEKNDSSKYSLGNNSS
References
External Links
ResourceLink
Saccharomyces Genome Database SUR1
Uniprot IDP33300
Uniprot NameSUR1_YEAST
GenBank Gene IDD26581
Genebank Protein ID976268
General Reference
  • Desfarges, L., Durrens, P., Juguelin, H., Cassagne, C., Bonneu, M., Aigle, M. (1993). "Yeast mutants affected in viability upon starvation have a modified phospholipid composition." Yeast 9:267-277.8488727
  • Takita, Y., Ohya, Y., Anraku, Y. (1995). "The CLS2 gene encodes a protein with multiple membrane-spanning domains that is important Ca2+ tolerance in yeast." Mol Gen Genet 246:269-281.7854312
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Uemura, S., Kihara, A., Inokuchi, J., Igarashi, Y. (2003). "Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p." J Biol Chem 278:45049-45055.12954640
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956